(Q34785660)

4 August 2017

title

PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer (English)

1 reference

4 August 2017

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S M Wigfield

1

1 reference

4 August 2017

S C Winter

2

1 reference

4 August 2017

A Giatromanolaki

3

1 reference

4 August 2017

J Taylor

4

1 reference

4 August 2017

M L Koukourakis

5

1 reference

4 August 2017

A L Harris

6

1 reference

4 August 2017

language of work or name

English

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publication date

10 June 2008

1 reference

British Journal of Cancer

4 August 2017

published in

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4 August 2017

volume

98

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4 August 2017

issue

12

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4 August 2017

page(s)

1975-1984

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describes a project that uses

4 August 2017

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/2441961

based on heuristic

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/sj.bjc.6604356

0 references

cites work

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Hypoxia signalling controls metabolic demand

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Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

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HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

8 July 2018

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HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2441961

Characterization of testis-specific isoenzyme of human pyruvate dehydrogenase

8 July 2018

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8 July 2018

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Pyruvate dehydrogenase and pyruvate dehydrogenase kinase expression in non small cell lung cancer and tumor-associated stroma

8 July 2018

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Pyruvate dehydrogenase complex: metabolic link to ischemic brain injury and target of oxidative stress

8 July 2018

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Rational siRNA design for RNA interference

8 July 2018

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On respiratory impairment in cancer cells

8 July 2018

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8 July 2018

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8 July 2018

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Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs

8 July 2018

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Regulation of the activity of the pyruvate dehydrogenase complex

8 July 2018

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8 July 2018

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Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer

8 July 2018

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Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival

8 July 2018

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A trail of research from lipoic acid to alpha-keto acid dehydrogenase complexes

8 July 2018

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A new mathematical model for relative quantification in real-time RT-PCR

8 July 2018

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Muscle fiber type comparison of PDH kinase activity and isoform expression in fed and fasted rats

8 July 2018

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Evidence that pyruvate dehydrogenase kinase belongs to the ATPase/kinase superfamily

8 July 2018

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8 July 2018

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Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase isoenzyme 4 in rat heart

8 July 2018

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Mitochondrial alpha-ketoacid dehydrogenase kinases: a new family of protein kinases

8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2441961

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2441961

Correlation of high lactate levels in head and neck tumors with incidence of metastasis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2441961

Characterization of the cellular reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT): subcellular localization, substrate dependence, and involvement of mitochondrial electron transport in MTT reduction

8 July 2018

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Transformation linked decrease of pyruvate dehydrogenase complex in human epidermis

8 July 2018

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

8 July 2018

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The 2-oxo acid dehydrogenase complexes: recent advances

8 July 2018

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Reaction mechanism of the heterotetrameric (alpha2beta2) E1 component of 2-oxo acid dehydrogenase multienzyme complexes

8 July 2018

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https://api.crossref.org/works/10.1038%2FSJ.BJC.6604356

Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.BJC.6604356

Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: a metabolic survival role for tumor-associated stroma

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.BJC.6604356

Lactate dehydrogenase 5 (LDH5) relates to up-regulated hypoxia inducible factor pathway and metastasis in colorectal cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.BJC.6604356

The intermediary metabolite pyruvate attenuates stunning and reduces infarct size in in vivo porcine myocardium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6604356

Selective modification of pyruvate dehydrogenase kinase isoform expression in rat pancreatic islets elicited by starvation and activation of peroxisome proliferator-activated receptor-alpha: implications for glucose-stimulated insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6604356

Expression and regulation of pyruvate dehydrogenase kinase isoforms in the developing rat heart and in adulthood: role of thyroid hormone status and lipid supply

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6604356

Prognostic Value of an Activation State Marker for Epidermal Growth Factor Receptor in Tissue Microarrays of Head and Neck Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6604356

Relation of Erythropoietin and Erythropoietin Receptor Expression to Hypoxia and Anemia in Head and Neck Squamous Cell Carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6604356

The relation between hypoxia-inducible factor (HIF)-1α and HIF-2α expression with anemia and outcome in surgically treated head and neck cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6604356

Cell structure and dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6604356

Hypoxia regulatory elements of the human vascular endothelial growth factor gene

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18542064

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Aqueous soluble tetrazolium/formazan MTS as an indicator of NADH- and NADPH-dependent dehydrogenase activity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18542064

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/SJ.BJC.6604356

1 reference

Dimensions Publication ID

4 August 2017

0 references

1 reference

4 August 2017

1 reference