(Q34786459)

4 August 2017

1 reference

title

Cellular basis of drug-induced torsades de pointes (English)

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4 August 2017

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D M Roden

1

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4 August 2017

language of work or name

English

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publication date

16 June 2008

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British Journal of Pharmacology

4 August 2017

published in

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4 August 2017

volume

154

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4 August 2017

issue

7

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4 August 2017

page(s)

1502-1507

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Uptake of cardiovascular drugs into the human heart: expression, regulation, and function of the carnitine transporter OCTN2 (SLC22A5).

4 August 2017

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Subunit interaction determines IKs participation in cardiac repolarization and repolarization reserve

8 July 2018

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8 July 2018

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Predictive in silico modeling for hERG channel blockers

8 July 2018

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Oral erythromycin and the risk of sudden death from cardiac causes

8 July 2018

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Drug-induced torsades de pointes and implications for drug development.

8 July 2018

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8 July 2018

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8 July 2018

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Risk stratification in the long-QT syndrome.

8 July 2018

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8 July 2018

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Cardiac arrest and ventricular arrhythmia in patients taking antipsychotic drugs: cohort study using administrative data

8 July 2018

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Drug-induced long-QT syndrome associated with a subclinical SCN5A mutation

8 July 2018

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Variant of SCN5A sodium channel implicated in risk of cardiac arrhythmia

8 July 2018

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Spontaneous adverse event reports of serious ventricular arrhythmias, QT prolongation, syncope, and sudden death in patients treated with cisapride

8 July 2018

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Allelic variants in long-QT disease genes in patients with drug-associated torsades de pointes

8 July 2018

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Importance of QT interval determination and renal function assessment during antiarrhythmic drug therapy

8 July 2018

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Molecular and cellular mechanisms of cardiac arrhythmias

8 July 2018

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Cardiovascular drugs. Dofetilide

8 July 2018

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A structural basis for drug-induced long QT syndrome

8 July 2018

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The potential for QT prolongation and proarrhythmia by non-antiarrhythmic drugs: clinical and regulatory implications. Report on a policy conference of the European Society of Cardiology

8 July 2018

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Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate.

8 July 2018

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Cellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with ST-segment elevation

8 July 2018

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Dofetilide in patients with congestive heart failure and left ventricular dysfunction. Danish Investigations of Arrhythmia and Mortality on Dofetilide Study Group

8 July 2018

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The M cell: its contribution to the ECG and to normal and abnormal electrical function of the heart

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492095

MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia

8 July 2018

1 reference

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Ionic mechanism of ibutilide in human atrium: evidence for a drug-induced Na+ current through a nifedipine inhibited inward channel

8 July 2018

1 reference

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Mortality in the Survival With ORal D-sotalol (SWORD) trial: why did patients die?

8 July 2018

1 reference

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Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. The SWORD Investigators. Survival With Oral d-Sotalol.

8 July 2018

1 reference

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Ibutilide, a methanesulfonanilide antiarrhythmic, is a potent blocker of the rapidly activating delayed rectifier K+ current (IKr) in AT-1 cells. Concentration-, time-, voltage-, and use-dependent effects.

8 July 2018

1 reference

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A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

8 July 2018

1 reference

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Anti-minK Antisense Decreases the Amplitude of the Rapidly Activating Cardiac Delayed Rectifier K + Current

8 July 2018

1 reference

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Ventricular tachycardia with 2 variable opposing foci

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492095

Approaches to sudden death from coronary heart disease

8 July 2018

1 reference

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Action potential prolongation and induction of abnormal automaticity by low quinidine concentrations in canine Purkinje fibers. Relationship to potassium and cycle length.

8 July 2018

1 reference

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Incidence and clinical features of the quinidine-associated long QT syndrome: implications for patient care

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492095

Plasma concentrations of quinidine, its major metabolites, and dihydroquinidine in patients with torsades de pointes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492095

Pharmacological response of quinidine induced early afterdepolarisations in canine cardiac Purkinje fibres: insights into underlying ionic mechanisms.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492095

Cardiotoxic effect with convulsions in terfenadine overdose

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492095

The role of sodium channels in the effects of the cardiotonic compound DPI 201-106 on contractility and membrane potentials in isolated mammalian heart preparations.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492095

Clinical safety profile of sotalol in patients with arrhythmias

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492095

Quinidine-induced ventricular flutter and fibrillation without digitalis therapy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492095

Restricting excessive cardiac action potential and QT prolongation: a vital role for IKs in human ventricular muscle.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492095

A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492095

Amplified transmural dispersion of repolarization as the basis for arrhythmogenesis in a canine ventricular-wedge model of short-QT syndrome

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492095

Pentamidine-induced long QT syndrome and block of hERG trafficking

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492095

Mechanisms of arsenic-induced prolongation of cardiac repolarization

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492095

Evidence for a cardiac ion channel mutation underlying drug-induced QT prolongation and life-threatening arrhythmias

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2492095

Effect of dofetilide in patients with recent myocardial infarction and left-ventricular dysfunction: a randomised trial

26 October 2018

1 reference

12 December 2020

Delayed sodium channel inactivation mimics long QT syndrome 3

1 reference

12 December 2020

Calmodulin kinase inhibition prevents development of the arrhythmogenic transient inward current

1 reference

12 December 2020

Exaggerated QT prolongation after cardioversion of atrial fibrillation

1 reference

12 December 2020

Characteristics and distribution of M cells in arterially perfused canine left ventricular wedge preparations

1 reference

12 December 2020

An underrecognized challenge in evaluating postmarketing drug safety

1 reference

12 December 2020

Prediction of hERG K+ blocking potency: application of structural knowledge

1 reference

12 December 2020

Protecting the heart against arrhythmias: potassium current physiology and repolarization reserve

1 reference

12 December 2020

Comparative in vitro electrophysiology of quinidine, its major metabolites and dihydroquinidine

1 reference

12 December 2020

Mechanism of the cardiotoxic actions of terfenadine

1 reference

12 December 2020

Role of Na+:Ca2+ exchange current in Cs(+)-induced early afterdepolarizations in Purkinje fibers

1 reference

12 December 2020

Cellular and Ionic Mechanisms Underlying Erythromycin-Induced Long QT Intervals and Torsade de Pointes

1 reference

12 December 2020

KVLQT1 C-terminal missense mutation causes a forme fruste long-QT syndrome

1 reference

12 December 2020

Taking the "idio" out of "idiosyncratic": predicting torsades de pointes

1 reference

12 December 2020

Prolonged Q-T interval and severe tachyarrhythmias, common features of sotalol intoxication

1 reference

12 December 2020

Identifiers

DOI

10.1038/BJP.2008.238

1 reference

4 August 2017

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4 August 2017

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