(Q34786873)

4 August 2017

title

The hidden energetics of ligand binding and activation in a glutamate receptor (English)

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4 August 2017

1 reference

Albert Y Lau

1

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4 August 2017

Benoît Roux

series ordinal

2

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4 August 2017

publication date

13 February 2011

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Nature Structural & Molecular Biology

4 August 2017

published in

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4 August 2017

volume

18

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4 August 2017

issue

3

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4 August 2017

page(s)

283-287

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All-atom empirical potential for molecular modeling and dynamics studies of proteins

4 August 2017

cites work

1 reference

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Domain organization and function in GluK2 subtype kainate receptors.

8 July 2018

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On the mechanisms of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor binding to glutamate and kainate

8 July 2018

1 reference

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Enhanced Efficacy without Further Cleft Closure: Reevaluating Twist as a Source of Agonist Efficacy in AMPA Receptors

8 July 2018

1 reference

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X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

8 July 2018

1 reference

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Improved prediction of protein side-chain conformations with SCWRL4

8 July 2018

1 reference

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8 July 2018

1 reference

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Full Domain Closure of the Ligand-binding Core of the Ionotropic Glutamate Receptor iGluR5 Induced by the High Affinity Agonist Dysiherbaine and the Functional Antagonist 8,9-Dideoxyneodysiherbaine

8 July 2018

1 reference

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Mechanisms of Antagonism of the GluR2 AMPA Receptor: Structure and Dynamics of the Complex of Two Willardiine Antagonists with the Glutamate Binding Domain

8 July 2018

1 reference

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Mechanism of partial agonism at the GluR2 AMPA receptor: Measurements of lobe orientation in solution

8 July 2018

1 reference

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Structural and single-channel results indicate that the rates of ligand binding domain closing and opening directly impact AMPA receptor gating

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075596

Rigid body essential X-ray crystallography: distinguishing the bend and twist of glutamate receptor ligand binding domains

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075596

The free energy landscapes governing conformational changes in a glutamate receptor ligand-binding domain

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075596

Interdomain interactions in AMPA and kainate receptors regulate affinity for glutamate.

8 July 2018

1 reference

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Glutamate receptors at atomic resolution

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075596

Automatic atom type and bond type perception in molecular mechanical calculations

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075596

Structural determinants of agonist-specific kinetics at the ionotropic glutamate receptor 2.

8 July 2018

1 reference

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Mechanism of partial agonist action at the NR1 subunit of NMDA receptors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075596

Calculation of absolute protein-ligand binding free energy from computer simulations

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075596

AMPA receptor binding cleft mutations that alter affinity, efficacy, and recovery from desensitization.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075596

Development and testing of a general amber force field

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075596

Chemistry and conformation of the ligand-binding domain of GluR2 subtype of glutamate receptors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075596

ModLoop: automated modeling of loops in protein structures

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075596

Competitive antagonism of AMPA receptors by ligands of different classes: crystal structure of ATPO bound to the GluR2 ligand-binding core, in comparison with DNQX

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075596

Structural basis for AMPA receptor activation and ligand selectivity: crystal structures of five agonist complexes with the GluR2 ligand-binding core

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075596

Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075596

ZK200775: a phosphonate quinoxalinedione AMPA antagonist for neuroprotection in stroke and trauma

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075596

Agonist-induced isomerization in a glutamate receptor ligand-binding domain. A kinetic and mutagenetic analysis.

8 July 2018

1 reference

Evolution of glutamate interactions during binding to a glutamate receptor

21 January 2018

1 reference

Exploring the GluR2 ligand-binding core in complex with the bicyclical AMPA analogue (S)-4-AHCP.

21 January 2018

1 reference

THE weighted histogram analysis method for free-energy calculations on biomolecules. I. The method

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1038/NSMB.2010

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4 August 2017

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4 August 2017

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