(Q34787891)

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MEK5 is activated by shear stress, activates ERK5 and induces KLF4 to modulate TNF responses in human dermal microvascular endothelial cells

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21166929%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

MEK5 is activated by shear stress, activates ERK5 and induces KLF4 to modulate TNF responses in human dermal microvascular endothelial cells (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21166929%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

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2

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18 January 2020

author name string

Paul R Clark

1

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18 January 2020

Martin S Kluger

3

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18 January 2020

Maurice Morelock

4

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18 January 2020

Adedayo Hanidu

5

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18 January 2020

Zhenhao Qi

6

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18 January 2020

Revati J Tatake

7

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18 January 2020

Jordan S Pober

8

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18 January 2020

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1 February 2011

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18 January 2020

Microcirculation

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18 January 2020

18

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18 January 2020

2

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18 January 2020

102-117

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18 January 2020

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3075844/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Defining the regulation of KLF4 expression and its downstream transcriptional targets in vascular endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075844

8 July 2018

Role of TNF-alpha in vascular dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075844

8 July 2018

Identification of pharmacological inhibitors of the MEK5/ERK5 pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075844

8 July 2018

Tumor necrosis factor-alpha downregulates endothelial nitric oxide synthase mRNA stability via translation elongation factor 1-alpha 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075844

8 July 2018

Fluid shear stress inhibits TNF-mediated JNK activation via MEK5-BMK1 in endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075844

8 July 2018

Atheroprotective signaling mechanisms activated by steady laminar flow in endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075844

8 July 2018

Regulation of arterial-venous differences in tumor necrosis factor responsiveness of endothelial cells by anatomic context

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075844

8 July 2018

Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075844

8 July 2018

Prolonged shear stress and KLF2 suppress constitutive proinflammatory transcription through inhibition of ATF2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075844

8 July 2018

Endothelial cell dysfunction, injury and death.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075844

8 July 2018

Noninvasive evaluation of wall shear stress on retinal microcirculation in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075844

8 July 2018

Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075844

8 July 2018

Transcriptional regulation of tissue-specific genes by the ERK5 mitogen-activated protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075844

8 July 2018

The role of shear stress in the pathogenesis of atherosclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075844

8 July 2018

Role of the BMK1/ERK5 signaling pathway: lessons from knockout mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075844

8 July 2018

KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075844

8 July 2018

Stress and vascular responses: atheroprotective effect of laminar fluid shear stress in endothelial cells: possible role of mitogen-activated protein kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075844

8 July 2018

Prolonged fluid shear stress induces a distinct set of endothelial cell genes, most specifically lung Krüppel-like factor (KLF2)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075844

8 July 2018

Endothelial activation: intracellular signaling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075844

8 July 2018

DNA microarray reveals changes in gene expression of shear stressed human umbilical vein endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075844

8 July 2018

Endothelial dysfunction, hemodynamic forces, and atherogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075844

8 July 2018

Mekk3 is essential for early embryonic cardiovascular development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075844

8 July 2018

MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075844

8 July 2018

The transcription factor MEF2C-null mouse exhibits complex vascular malformations and reduced cardiac expression of angiopoietin 1 and VEGF

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075844

8 July 2018

BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075844

8 July 2018

Inducibility and expression of microvascular endothelial adhesion molecules in lesional, perilesional, and uninvolved skin of psoriatic patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075844

8 July 2018

Identification of an inducible endothelial-leukocyte adhesion molecule

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075844

8 July 2018

Immunologic interactions of T lymphocytes with vascular endothelium.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075844

8 July 2018

Electrical method for detection of endothelial cell shape change in real time: assessment of endothelial barrier function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075844

8 July 2018

Kruppel-like factor 4 regulates endothelial inflammation.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00071.X

21 January 2018

Tumor necrosis factor alpha-mediated reduction of KLF2 is due to inhibition of MEF2 by NF-kappaB and histone deacetylases

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00071.X

21 January 2018

Kruppel-like factor 2 inhibits protease activated receptor-1 expression and thrombin-mediated endothelial activation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00071.X

21 January 2018

Vascular bed origin dictates flow pattern regulation of endothelial adhesion molecule expression.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00071.X

21 January 2018

Effects of TNF-alpha and curcumin on the expression of thrombomodulin and endothelial protein C receptor in human endothelial cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00071.X

21 January 2018

Regulation of TNF-alpha-induced reorganization of the actin cytoskeleton and cell-cell junctions by Rho, Rac, and Cdc42 in human endothelial cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00071.X

21 January 2018

Monocyte adhesion and spreading on human endothelial cells is dependent on Rho-regulated receptor clustering

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00071.X

21 January 2018

Thrombin and protease-activated receptors (PARs) in atherothrombosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075844

26 October 2018

Ultrastructure of the human dermal microcirculation. II. The capillary loops of the dermal papillae

1 reference

https://pubmed.ncbi.nlm.nih.gov/21166929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of an activation antigen on postcapillary venular endothelium in human skin organ culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/21166929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterogeneity of dermal microvascular endothelial cell antigen expression and cytokine responsiveness in situ and in cell culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/21166929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of sustained E-selectin expression in cultured human dermal microvascular endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21166929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Laminar shear stress: mechanisms by which endothelial cells transduce an atheroprotective force

1 reference

https://pubmed.ncbi.nlm.nih.gov/21166929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluid shear stress stimulates big mitogen-activated protein kinase 1 (BMK1) activity in endothelial cells. Dependence on tyrosine kinases and intracellular calcium

1 reference

https://pubmed.ncbi.nlm.nih.gov/21166929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

KLF2 provokes a gene expression pattern that establishes functional quiescent differentiation of the endothelium

1 reference

https://pubmed.ncbi.nlm.nih.gov/21166929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

KLF2 suppresses TGF-beta signaling in endothelium through induction of Smad7 and inhibition of AP-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/21166929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased ICAM-1 expression causes endothelial cell leakiness, cytoskeletal reorganization and junctional alterations

1 reference

https://pubmed.ncbi.nlm.nih.gov/21166929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1549-8719.2010.00071.X

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21166929%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21166929%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21166929%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

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