(Q34792879)

4 August 2017

1 reference

title

Designing bisubstrate analog inhibitors for protein kinases (English)

1 reference

4 August 2017

Keykavous Parang

1

1 reference

PubMed ID

12191607

4 August 2017

Philip A Cole

series ordinal

2

1 reference

4 August 2017

1 February 2002

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Pharmacology & Therapeutics

4 August 2017

1 reference

4 August 2017

93

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4 August 2017

2-3

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4 August 2017

145-157

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Probing the catalytic mechanism of the insulin receptor kinase with a tetrafluorotyrosine-containing peptide substrate

4 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

Mechanistic alternatives in phosphate monoester hydrolysis: what conclusions can be drawn from available experimental data?

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

c-Src, receptor tyrosine kinases, and human cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

Chemical basis for enzyme catalysis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

Rational design of enzyme inhibitors: multisubstrate analogue inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

Enhanced affinities and specificities of consolidated ligands for the Src homology (SH) 3 and SH2 domains of Abelson protein-tyrosine kinase.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

Synthesis of [beta-(4-pyridyl-1-oxide)-L-alanine4]-angiotensin I as a potential suicide substrate for protein-tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

Inhibition of hexokinase by multisubstrate analogs

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

Binding of pyrimidin-2-one ribonucleoside by cytidine deaminase as the transition-state analogue 3,4-dihydrouridine and the contribution of the 4-hydroxyl group to its binding affinity

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

Protein tyrosine kinase structure and function

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

A thousand and one protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

Signaling--2000 and beyond

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

Pseudosubstrate-based peptide inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

Synthesis and evaluation of multisubstrate inhibitors of an oncogene-encoded tyrosine-specific protein kinase. 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

Protein kinase inhibitors: the tyrosine-specific protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

Acquisition of high-affinity, SH2-targeted ligands via a spatially focused library

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

Tethered bisubstrate derivatives as probes for mechanism and as inhibitors of aminoglycoside 3'-phosphotransferases

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

Bi-substrate analogue ligands for affinity chromatography of protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

Nonphosphorylatable tyrosine surrogates. Implications for protein kinase inhibitor design

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

Entropic Contributions to Rate Accelerations in Enzymic and Intramolecular Reactions and the Chelate Effect

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

Mechanism-based design of a protein kinase inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

Protein kinase phosphorylation site sequences and consensus specificity motifs: tabulations

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

How do protein kinases recognize their substrates?

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

Molecular rulers: an assessment of distance and spatial relationships of Src tyrosine kinase Sh2 and active site regions.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

[11] Transition state and multisubstrate analog inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

Design of potent protein kinase inhibitors using the bisubstrate approach

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

Cell signaling by receptor tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

Small molecule inhibitors of the platelet-derived growth factor receptor, the fibroblast growth factor receptor, and Src family tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

Peptide and protein phosphorylation by protein tyrosine kinase Csk: insights into specificity and mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

SH2 domains recognize specific phosphopeptide sequences

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

Three protein kinase structures define a common motif

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

Synergistic activity of the new ABL-specific tyrosine kinase inhibitor STI571 and chemotherapeutic drugs on BCR-ABL-positive chronic myelogenous leukemia cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

Sulfonylbenzoyl-nitrostyrenes: potential bisubstrate type inhibitors of the EGF-receptor tyrosine protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

A new class of compounds, peptide derivatives of adenosine 5'-carboxylic acid, includes inhibitors of ATP receptor-mediated responses.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

Recent advances in the design and synthesis of SH2 inhibitors of Src, Grb2 and ZAP-70.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

Utilization of the inhibitor protein of adenosine cyclic monophosphate-dependent protein kinase, and peptides derived from it, as tools to study adenosine cyclic monophosphate-mediated cellular processes

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

Flexibility of interdomain contacts revealed by topological isomers of bivalent consolidated ligands to the dual Src homology domain SH(32) of abelson.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

Crystal structures of c-Src reveal features of its autoinhibitory mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

Growth factor receptor tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900184-5

7 January 2021

10.1016/S0163-7258(02)00184-5

Identifiers

DOI

1 reference

4 August 2017

1 reference

PubMed ID

12191607