(Q34801664)

4 August 2017

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title

Mitochondrial function and dysfunction in the cell: its relevance to aging and aging-related disease (English)

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4 August 2017

David G Nicholls

1

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4 August 2017

1 November 2002

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International Journal of Biochemistry & Cell Biology

4 August 2017

1 reference

4 August 2017

34

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4 August 2017

1372-1381

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4 August 2017

11

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Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced

4 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Mitochondria and neuronal survival

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Mitochondrial free radical generation, oxidative stress, and aging

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Mitochondrial calcium transport

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Physiological roles of nicotinamide nucleotide transhydrogenase

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Mitochondrial respiratory chain-dependent generation of superoxide anion and its release into the intermembrane space

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Localization at complex I and mechanism of the higher free radical production of brain nonsynaptic mitochondria in the short-lived rat than in the longevous pigeon.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Monoamine oxidase and mitochondrial respiration

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Energy transduction in intact synaptosomes. Influence of plasma-membrane depolarization on the respiration and membrane potential of internal mitochondria determined in situ

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Mitochondrial proton leak and the uncoupling proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Analysis of the control of respiration rate, phosphorylation rate, proton leak rate and protonmotive force in isolated mitochondria using the 'top-down' approach of metabolic control theory

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Threshold effects in synaptosomal and nonsynaptic mitochondria from hippocampal CA1 and paramedian neocortex brain regions.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Calcium regulation of oxidative phosphorylation in rat skeletal muscle mitochondria.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Titrating the effects of mitochondrial complex I impairment in the cell physiology

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Mitochondrial oxygen radical generation and leak: sites of production in states 4 and 3, organ specificity, and relation to aging and longevity

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Mitochondrial dysfunction in neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Oxidative stress, mitochondrial respiration, and Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity. Implications for Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

The Effective Proton Conductance of the Inner Membrane of Mitochondria from Brown Adipose Tissue. Dependency on Proton Electrochemical Potential Gradient

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Mitochondria deficient in complex I activity are depolarized by hydrogen peroxide in nerve terminals: relevance to Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Brain mitochondrial complex I inactivation by oxidative modification.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Nitric oxide inhibits mitochondrial NADH:ubiquinone reductase activity through peroxynitrite formation

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Thiol oxidation and loss of mitochondrial complex I precede excitatory amino acid-mediated neurodegeneration.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Effect of thiol modification on brain mitochondrial complex I activity.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Energy thresholds in brain mitochondria. Potential involvement in neurodegeneration.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

N-acetylcysteine elicited increase in complex I activity in synaptic mitochondria from aged mice: implications for treatment of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Mitochondrial dysfunction in Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Functional analysis of lymphoblast and cybrid mitochondria containing the 3460, 11778, or 14484 Leber's hereditary optic neuropathy mitochondrial DNA mutation

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Human complex I defects in neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Use of transmitochondrial cybrids to assign a complex I defect to the mitochondrial DNA-encoded NADH dehydrogenase subunit 6 gene mutation at nucleotide pair 14459 that causes Leber hereditary optic neuropathy and dystonia

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Leber hereditary optic neuropathy: how do mitochondrial DNA mutations cause degeneration of the optic nerve?

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Delayed excitotoxic neurodegeneration induced by excitatory amino acid agonists in isolated retina

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Adenosine triphosphate degradation products after oxidative stress and metabolic dysfunction in cultured retinal cells

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Involvement of a caspase-3-like cysteine protease in 1-methyl-4-phenylpyridinium-mediated apoptosis of cultured cerebellar granule neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Oxidative damage during aging targets mitochondrial aconitase

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

The alpha-ketoglutarate dehydrogenase complex in neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Declines in mitochondrial respiration during cardiac reperfusion: age-dependent inactivation of alpha-ketoglutarate dehydrogenase

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Inhibition of Krebs cycle enzymes by hydrogen peroxide: A key role of [alpha]-ketoglutarate dehydrogenase in limiting NADH production under oxidative stress.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Age-dependent striatal excitotoxic lesions produced by the endogenous mitochondrial inhibitor malonate

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

3-Nitropropionic acid exacerbates N-methyl-D-aspartate toxicity in striatal culture by multiple mechanisms.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Secondary abnormalities of mitochondrial DNA associated with neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

A defect in the cytochrome b large subunit in complex II causes both superoxide anion overproduction and abnormal energy metabolism in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Enhancement of hydrogen peroxide formation by protophores and ionophores in antimycin-supplemented mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Decreased glutathione results in calcium-mediated cell death in PC12.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

The influence of respiration and ATP hydrolysis on the proton-electrochemical gradient across the inner membrane of rat-liver mitochondria as determined by ion distribution.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Mitochondrial uncoupling proteins: from mitochondria to the regulation of energy balance

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

The regulation of extramitochondrial free calcium ion concentration by rat liver mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

The regulation of brain mitochondrial calcium-ion transport. The role of ATP in the discrimination between kinetic and membrane-potential-dependent calcium-ion efflux mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Regulation of the intracellular free calcium concentration in single rat dorsal root ganglion neurones in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Mitochondrial membrane potential and glutamate excitotoxicity in cultured cerebellar granule cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Mitochondrial control of acute glutamate excitotoxicity in cultured cerebellar granule cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

The mitochondrial permeability transition pore and its role in cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Mitochondrial permeability transition is a central coordinating event of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Quantitative assay by flow cytometry of the mitochondrial membrane potential in intact cells

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Collapse of the inner mitochondrial transmembrane potential is not required for apoptosis of HL60 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2

1 reference

https://api.crossref.org/works/10.1016%2FS1357-2725%2802%2900077-8

7 January 2021

10.1016/S1357-2725(02)00077-8

Identifiers

DOI

1 reference

4 August 2017

1 reference

PubMed ID

12200032