(Q34802499)

4 August 2017

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title

Sphingosine 1-phosphate as a therapeutic agent (English)

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4 August 2017

Spiegel S

1

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PubMed ID

12200669

4 August 2017

Kolesnick R

series ordinal

2

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4 August 2017

1 September 2002

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4 August 2017

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4 August 2017

16

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4 August 2017

9

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4 August 2017

1596-1602

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https://scigraph.springernature.com/pub.10.1038/sj.leu.2402611

4 August 2017

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Signal transduction through lipid second messengers

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Functions of ceramide in coordinating cellular responses to stress

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7 January 2021

Sphingolipids--the enigmatic lipid class: biochemistry, physiology, and pathophysiology

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7 January 2021

Ceramide and apoptosis

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7 January 2021

Sphingosine-1-phosphate: signaling inside and out.

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7 January 2021

Enzymes of sphingolipid metabolism: from modular to integrative signaling

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7 January 2021

Sphingolipid metabolism and cell growth regulation.

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7 January 2021

Regulation of ceramide production and apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Apoptosis-associated signaling pathways are required for chemotherapy-mediated female germ cell destruction.

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Molecular cloning and functional characterization of murine sphingosine kinase

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Functional characterization of human sphingosine kinase-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

The LCB4 (YOR171c) and LCB5 (YLR260w) genes of Saccharomyces encode sphingoid long chain base kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Characterization of sphingolipid long-chain base kinase in Arabidopsis thaliana

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Sphingomyelin-derived lipids differentially regulate the extracellular signal-regulated kinase 2 (ERK-2) and c-Jun N-terminal kinase (JNK) signal cascades in airway smooth muscle

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Differential regulation of sphingomyelinase and ceramidase activities by growth factors and cytokines. Implications for cellular proliferation and differentiation

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7 January 2021

Involvement of sphingosine 1-phosphate in nerve growth factor-mediated neuronal survival and differentiation

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7 January 2021

Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors

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7 January 2021

Bimodal regulation of ceramidase by interleukin-1beta. Implications for the regulation of cytochrome p450 2C11.

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7 January 2021

Calcium mobilization via sphingosine kinase in signalling by the Fc epsilon RI antigen receptor

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

FcgammaRI coupling to phospholipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular trafficking

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Divergence in signal transduction pathways of platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) receptors. Involvement of sphingosine 1-phosphate in PDGF but not EGF signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survival

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Sphingosine 1-phosphate inhibits activation of caspases that cleave poly(ADP-ribose) polymerase and lamins during Fas- and ceramide-mediated apoptosis in Jurkat T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

An oncogenic role of sphingosine kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

The DPL1 gene is involved in mediating the response to nutrient deprivation in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22(1)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Ras and Rho GTPases: a family reunion

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Rho GTPases and the actin cytoskeleton

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Endothelial-perivascular cell signaling in vascular development: lessons from knockout mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Stimulation of sphingosine-1-phosphate formation by the P2Y(2) receptor in HL-60 cells: Ca(2+) requirement and implication in receptor-mediated Ca(2+) mobilization, but not MAP kinase activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Formyl peptide receptor signaling in HL-60 cells through sphingosine kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Drought-induced guard cell signal transduction involves sphingosine-1-phosphate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Sphingosine kinase-mediated calcium signaling by muscarinic acetylcholine receptors.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

1 reference

7 January 2021

Sphingoid base 1-phosphate phosphatase: a key regulator of sphingolipid metabolism and stress response.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Involvement of yeast sphingolipids in the heat stress response of Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Calcium release-activated calcium current (ICRAC) is a direct target for sphingosine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

The balance between sphingosine and sphingosine-1-phosphate is decisive for mast cell activation after Fc epsilon receptor I triggering

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Tumor necrosis factor- induces adhesion molecule expression through the sphingosine kinase pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

High density lipoproteins (HDL) interrupt the sphingosine kinase signaling pathway. A possible mechanism for protection against atherosclerosis by HDL

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Inhibition of sphingolipid induced apoptosis by caspase inhibitors indicates that sphingosine acts in an earlier part of the apoptotic pathway than ceramide

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Suppression of bcl-2 gene expression by sphingosine in the apoptosis of human leukemic HL-60 cells during phorbol ester-induced terminal differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Partial Inhibition of Multidrug Resistance by Safingol Is Independent of Modulation of P-glycoprotein Substrate Activities and Correlated with Inhibition of Protein Kinase C

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Effective cytotoxicity against human leukemias and chemotherapy-resistant leukemia cell lines by N-N-dimethylsphingosine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Sphingosine kinase inhibitors in the apoptosis of leukaemia cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Oocyte apoptosis: like sand through an hourglass

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Acid sphingomyelinase deficient mice: a model of types A and B Niemann-Pick disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Fragmentation and death (a.k.a. apoptosis) of ovulated oocytes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402611

7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2402611

1 reference

PubMed ID

12200669

Dimensions Publication ID

4 August 2017

0 references

1 reference

PubMed ID

12200669