(Q34804573)

4 August 2017

Agonist activation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site (English)

1 reference

4 August 2017

transmembrane protein

0 references

author name string

Jaskiran K Gill

1

1 reference

4 August 2017

Mari Savolainen

2

1 reference

4 August 2017

Gareth T Young

3

1 reference

4 August 2017

Ruud Zwart

4

1 reference

4 August 2017

Emanuele Sher

5

1 reference

4 August 2017

Neil S Millar

6

1 reference

4 August 2017

language of work or name

English

0 references

publication date

21 March 2011

1 reference

Proceedings of the National Academy of Sciences of the United States of America

4 August 2017

6

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

4 August 2017

108

1 reference

4 August 2017

14

1 reference

4 August 2017

5867-5872

1 reference

Nicotinic acetylcholine receptor transmembrane mutations convert ivermectin from a positive to a negative allosteric modulator

4 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Positive allosteric modulation of alpha7 neuronal nicotinic acetylcholine receptors: lack of cytotoxicity in PC12 cells and rat primary cortical neurons

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Potentiation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Diversity of vertebrate nicotinic acetylcholine receptors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Agonist-induced hump current production in heterologously-expressed human alpha4beta2-nicotinic acetylcholine receptors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Allosteric modulators of the alpha7 nicotinic acetylcholine receptor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Identification of domains influencing assembly and ion channel properties in alpha 7 nicotinic receptor and 5-HT3 receptor subunit chimaeras.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Nicotinic interactions with antipsychotic drugs, models of schizophrenia and impacts on cognitive function

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Allosteric modulation of nicotinic acetylcholine receptors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Neuronal nicotinic receptors: a perspective on two decades of drug discovery research

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Crystal structure of the extracellular domain of nAChR alpha1 bound to alpha-bungarotoxin at 1.94 A resolution

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Allosteric enhancers, allosteric agonists and ago-allosteric modulators: where do they bind and how do they act?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

An allosteric modulator of the alpha7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Distinct profiles of alpha7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Allosteric modifiers of neuronal nicotinic acetylcholine receptors: new methods, new opportunities.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Allosteric agonists of 7TM receptors: expanding the pharmacological toolbox

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Incorporation of the beta3 subunit has a dominant-negative effect on the function of recombinant central-type neuronal nicotinic receptors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Recent advances in Cys-loop receptor structure and function

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Refined structure of the nicotinic acetylcholine receptor at 4A resolution

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Cys-loop receptors: new twists and turns

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Inefficient cell-surface expression of hybrid complexes formed by the co-assembly of neuronal nicotinic acetylcholine receptor and serotonin receptor subunits

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Neuronal nicotinic acetylcholine receptors: from the gene to the disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Kinetic, mechanistic, and structural aspects of unliganded gating of acetylcholine receptor channels: a single-channel study of second transmembrane segment 12' mutants

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Ivermectin: a positive allosteric effector of the alpha7 neuronal nicotinic acetylcholine receptor.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Enhancement of glycine receptor function by ethanol is inversely correlated with molecular volume at position alpha267.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Paradoxical allosteric effects of competitive inhibitors on neuronal alpha7 nicotinic receptor mutants

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Molecular evolution of the nicotinic acetylcholine receptor: an example of multigene family in excitable cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Congenital myasthenic syndrome caused by prolonged acetylcholine receptor channel openings due to a mutation in the M2 domain of the epsilon subunit

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

GABAA receptor needs two homologous domains of the beta-subunit for activation by GABA but not by pentobarbital.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Spontaneous openings of the acetylcholine receptor channel

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Functional significance of aromatic amino acids from three peptide loops of the alpha 7 neuronal nicotinic receptor site investigated by site-directed mutagenesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Unconventional pharmacology of a neuronal nicotinic receptor mutated in the channel domain

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

A neuronal nicotinic acetylcholine receptor subunit (α7) is developmentally regulated and forms a homo-oligomeric channel blocked by α-BTX

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

Nicotinic receptors, allosteric proteins and medicine.

8 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1017975108

Methyl lycaconitine: A novel nicotinic antagonist.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1017975108

The correction of alpha7 nicotinic acetylcholine receptor concentration-response relationships in Xenopus oocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1017975108

Identification of binding sites in the nicotinic acetylcholine receptor for [3H]azietomidate, a photoactivatable general anesthetic

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1017975108

[3H]Benzophenone photolabeling identifies state-dependent changes in nicotinic acetylcholine receptor structure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1017975108

Spontaneous and agonist-induced openings of an acetylcholine receptor channel composed of bovine muscle ?-, ? and ?-subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1017975108

Species selectivity of a nicotinic acetylcholine receptor agonist is conferred by two adjacent extracellular beta4 amino acids that are implicated in the coupling of binding to channel gating.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1017975108

Channel opening motion of alpha7 nicotinic acetylcholine receptor as suggested by normal mode analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1017975108

Homomers of alpha 8 and alpha 7 subunits of nicotinic receptors exhibit similar channel but contrasting binding site properties.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078348

26 October 2018

Identifiers

DOI

10.1073/PNAS.1017975108

1 reference

release_wvaa2qhvinf6vjzgjcmt7y3j5e

4 August 2017

0 references

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/wvaa2qhvinf6vjzgjcmt7y3j5e

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMCID

3078348

1 reference

4 August 2017

1 reference