(Q34811649)

4 August 2017

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title

Chloroquine resistance in the malarial parasite, Plasmodium falciparum (English)

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4 August 2017

main subject

Plasmodium falciparum

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Lyann M B Ursos

1

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4 August 2017

Paul D Roepe

series ordinal

2

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4 August 2017

publication date

1 September 2002

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Medicinal Research Reviews

4 August 2017

published in

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4 August 2017

volume

22

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4 August 2017

issue

5

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4 August 2017

page(s)

465-491

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A comparison of the phenomenology and genetics of multidrug resistance in cancer cells and quinoline resistance in Plasmodium falciparum

4 August 2017

cites work

1 reference

Are ion-exchange processes central to understanding drug-resistance phenomena?

21 January 2018

1 reference

Altered drug translocation mediated by the MDR protein: direct, indirect, or both?

21 January 2018

1 reference

Verapamil reversal of chloroquine resistance in the malaria parasite Plasmodium falciparum is specific for resistant parasites and independent of the weak base effect

21 January 2018

1 reference

Analysis of drug transport kinetics in multidrug-resistant cells using a novel coumarin-vinblastine compound

21 January 2018

1 reference

Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum

21 January 2018

1 reference

Differential stimulation of the Na+/H+ exchanger determines chloroquine uptake in Plasmodium falciparum

21 January 2018

1 reference

Are altered pHi and membrane potential in hu MDR 1 transfectants sufficient to cause MDR protein-mediated multidrug resistance?

21 January 2018

1 reference

Amplification of pfmdr 1 associated with mefloquine and halofantrine resistance in Plasmodium falciparum from Thailand

21 January 2018

1 reference

Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum

21 January 2018

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Chloroquine resistance not linked to mdr-like genes in a Plasmodium falciparum cross

21 January 2018

1 reference

Lower electrical membrane potential and altered pHi homeostasis in multidrug-resistant (MDR) cells: further characterization of a series of MDR cell lines expressing different levels of P-glycoprotein.

21 January 2018

1 reference

Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line

21 January 2018

1 reference

Analysis of the steady-state and initial rate of doxorubicin efflux from a series of multidrug-resistant cells expressing different levels of P-glycoprotein

21 January 2018

1 reference

Hemoglobin degradation in the human malaria pathogen Plasmodium falciparum: a catabolic pathway initiated by a specific aspartic protease

21 January 2018

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A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum

21 January 2018

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Characterization of native and recombinant falcipain-2, a principal trophozoite cysteine protease and essential hemoglobinase of Plasmodium falciparum

21 January 2018

1 reference

Identification and characterization of falcilysin, a metallopeptidase involved in hemoglobin catabolism within the malaria parasite Plasmodium falciparum

21 January 2018

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Generation of hemoglobin peptides in the acidic digestive vacuole of Plasmodium falciparum implicates peptide transport in amino acid production

21 January 2018

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Aminopeptidases from Plasmodium falciparum, Plasmodium chabaudi chabaudi and Plasmodium berghei

21 January 2018

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A Plasmodium falciparum aminopeptidase gene belonging to the M1 family of zinc-metallopeptidases is expressed in erythrocytic stages

21 January 2018

1 reference

21 January 2018

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Haemoproteus and Schistosoma synthesize heme polymers similar to Plasmodium hemozoin and beta-hematin

21 January 2018

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An iron-carboxylate bond links the heme units of malaria pigment

21 January 2018

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Characterization of the malaria pigment (hemozoin) from the avian malaria parasite Plasmodium lophurae

21 January 2018

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Plasmodium lophurae: Composition and properties of hemozoin, the malarial pigment

21 January 2018

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The composition of haemozoin from Plasmodium falciparum

21 January 2018

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Haem polymerization in malaria

21 January 2018

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The structure of malaria pigment beta-haematin

21 January 2018

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Inhibition by chloroquine of a novel haem polymerase enzyme activity in malaria trophozoites

21 January 2018

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Malarial haemozoin/beta-haematin supports haem polymerization in the absence of protein

21 January 2018

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The chemical mechanism of beta-haematin formation studied by Mössbauer spectroscopy

21 January 2018

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The mechanism of beta-hematin formation in acetate solution. Parallels between hemozoin formation and biomineralization processes

21 January 2018

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Spectroscopic characterization of the heme-binding sites in Plasmodium falciparum histidine-rich protein 2.

21 January 2018

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Recent studies of the mineral phase in bone and its possible linkage to the organic matrix by protein-bound phosphate bonds

21 January 2018

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Quinoline anti-malarial drugs inhibit spontaneous formation of beta-haematin (malaria pigment).

21 January 2018

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Effects of antimalarials and protease inhibitors on plasmodial hemozoin production

21 January 2018

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Non-iron porphyrins inhibit beta-haematin (malaria pigment) polymerisation.

21 January 2018

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Metalloporphyrins inhibit beta-hematin (hemozoin) formation

21 January 2018

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Dissociation of aggregated ferroheme complexes and protoporphyrin IX by water-soluble polymers

21 January 2018

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Antimalarial drugs influence the pH dependent solubility of heme via apparent nucleation phenomena.

21 January 2018

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The structure of haem in pyridine/water mixtures and its implication in studies of haem catabolism

21 January 2018

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The dimerization of ferrihaems. IV. Studies on haematoferrihaem and a general appraisal of the nature and implications of dimerization

21 January 2018

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Relationship of global chloroquine transport and reversal of resistance in Plasmodium falciparum.

21 January 2018

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4-Aminoquinolines--past, present, and future: a chemical perspective

21 January 2018

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Quinoline-containing antimalarials—mode of action, drug resistance and its reversal an update with unresolved puzzles

21 January 2018

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On the molecular mechanism of chloroquine's antimalarial action

21 January 2018

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Morphological Effects of Chloroquine on Plasmodium berghei in Mice

21 January 2018

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Chloroquine Resistance in Malaria: Accessibility of Drug Receptors to Mefloquine

21 January 2018

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An assessment of drug-haematin binding as a mechanism for inhibition of haematin polymerisation by quinoline antimalarials

21 January 2018

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What is the precise role of human MDR 1 protein in chemotherapeutic drug resistance?

21 January 2018

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Uptake of [3H]chloroquine by drug-sensitive and -resistant strains of the human malaria parasite Plasmodium falciparum

21 January 2018

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Kinetic modelling of the response of Plasmodium falciparum to chloroquine and its experimental testing in vitro. Implications for mechanism of action of and resistance to the drug

21 January 2018

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Kinetic modelling of chloroquine uptake by malaria-infected erythrocytes. Assessment of the factors that may determine drug resistance

21 January 2018

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Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr1 gene and cross-resistance to halofantrine and quinine

21 January 2018

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Evidence for electrogenic accumulation of mefloquine by malarial parasites

21 January 2018

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The role of drug accumulation in 4-aminoquinoline antimalarial potency. The influence of structural substitution and physicochemical properties.

21 January 2018

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Digestive vacuolar pH of intact intraerythrocytic P. falciparum either sensitive or resistant to chloroquine

21 January 2018

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The effects of chloroquine and verapamil on digestive vacuolar pH of P. falciparum either sensitive or resistant to chloroquine

21 January 2018

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P. falciparum CG2, linked to chloroquine resistance, does not resemble Na+/H+ exchangers

21 January 2018

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Is the putative chloroquine resistance mediator CG2 the Na+/H+ exchanger of Plasmodium falciparum?

21 January 2018

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Evolution of a unique Plasmodium falciparum chloroquine-resistance phenotype in association with pfcrt polymorphism in Papua New Guinea and South America

21 January 2018

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Complex polymorphisms in an approximately 330 kDa protein are linked to chloroquine-resistant P. falciparum in Southeast Asia and Africa

21 January 2018

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Allelic modifications of the cg2 and cg1 genes do not alter the chloroquine response of drug-resistant Plasmodium falciparum

21 January 2018

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Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance

21 January 2018

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Chloroquine-resistant malaria

21 January 2018

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Conservation of a novel vacuolar transporter in Plasmodium species and its central role in chloroquine resistance of P. falciparum

21 January 2018

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Genetic mapping of the chloroquine-resistance locus on Plasmodium falciparum chromosome 7.

21 January 2018

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Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum

21 January 2018

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A molecular marker for chloroquine-resistant falciparum malaria

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MED.10016

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4 August 2017

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