(Q34811834)

4 August 2017

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title

Runx2, a multifunctional transcription factor in skeletal development (English)

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4 August 2017

Toshihisa Komori

1

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4 August 2017

1 January 2002

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Journal of Cellular Biochemistry

4 August 2017

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4 August 2017

87

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4 August 2017

1-8

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4 August 2017

1

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TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation

4 August 2017

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Differential regulation of the two principal Runx2/Cbfa1 n-terminal isoforms in response to bone morphogenetic protein-2 during development of the osteoblast phenotype.

21 January 2018

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Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development

21 January 2018

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1,25-(OH)2-vitamin D3 suppresses the bone-related Runx2/Cbfa1 gene promoter

21 January 2018

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Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation

21 January 2018

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A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development

21 January 2018

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Cbfa1 is a positive regulatory factor in chondrocyte maturation

21 January 2018

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Expression of the osteoblast differentiation factor RUNX2 (Cbfa1/AML3/Pebp2alpha A) is inhibited by tumor necrosis factor-alpha

21 January 2018

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CCAAT/enhancer-binding proteins (C/EBP) beta and delta activate osteocalcin gene transcription and synergize with Runx2 at the C/EBP element to regulate bone-specific expression.

21 January 2018

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Cbfa1 isoforms exert functional differences in osteoblast differentiation

21 January 2018

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Maturational disturbance of chondrocytes in Cbfa1-deficient mice

21 January 2018

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runt homology domain transcription factors (Runx, Cbfa, and AML) mediate repression of the bone sialoprotein promoter: evidence for promoter context-dependent activity of Cbfa proteins

21 January 2018

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Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation

21 January 2018

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A regulatory cascade involving retinoic acid, Cbfa1, and matrix metalloproteinases is coupled to the development of a process of perichondrial invasion and osteogenic differentiation during bone formation

21 January 2018

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Cbfa1 contributes to the osteoblast-specific expression of type I collagen genes

21 January 2018

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Regulation of chondrocyte differentiation by Cbfa1

21 January 2018

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Multilineage differentiation of Cbfa1-deficient calvarial cells in vitro

21 January 2018

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A fundamental transcription factor for bone and cartilage

21 January 2018

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Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts

21 January 2018

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Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia.

21 January 2018

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Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12.

21 January 2018

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Spatial and temporal expression pattern of Runx3 (Aml2) and Runx1 (Aml1) indicates non-redundant functions during mouse embryogenesis.

21 January 2018

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Causal relationship between the loss of RUNX3 expression and gastric cancer

21 January 2018

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Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures

21 January 2018

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Runt domain factor (Runx)-dependent effects on CCAAT/ enhancer-binding protein delta expression and activity in osteoblasts

21 January 2018

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Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia

21 January 2018

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The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation

21 January 2018

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Cbfa1 does not regulate RANKL gene activity in stromal/osteoblastic cells

21 January 2018

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Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development

21 January 2018

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Transcriptional regulation of osteopontin gene in vivo by PEBP2alphaA/CBFA1 and ETS1 in the skeletal tissues

21 January 2018

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Parathyroid hormone regulation of the rat collagenase-3 promoter by protein kinase A-dependent transactivation of core binding factor alpha1.

21 January 2018

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Role of Runx genes in chondrocyte differentiation

21 January 2018

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Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice

21 January 2018

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Two domains unique to osteoblast-specific transcription factor Osf2/Cbfa1 contribute to its transactivation function and its inability to heterodimerize with Cbfbeta

21 January 2018

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The osteoblast-specific transcription factor Cbfa1 contributes to the expression of osteoprotegerin, a potent inhibitor of osteoclast differentiation and function

21 January 2018

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The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation

21 January 2018

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Inhibition of osteoblast-specific transcription factor Cbfa1 by the cAMP pathway in osteoblastic cells. Ubiquitin/proteasome-dependent regulation.

21 January 2018

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Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytes

21 January 2018

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MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1.

21 January 2018

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Tissue specific regulation of VEGF expression during bone development requires Cbfa1/Runx2.

21 January 2018

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A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia

21 January 2018

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Promoter structure of mouse RANKL/TRANCE/OPGL/ODF gene

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JCB.10276

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4 August 2017

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PubMed ID

12210716