(Q34819094)

4 August 2017

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title

Reduction of N-hydroxylated compounds: amidoximes (N-hydroxyamidines) as pro-drugs of amidines (English)

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4 August 2017

Bernd Clement

1

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4 August 2017

language of work or name

English

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publication date

1 August 2002

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4 August 2017

published in

Drug Metabolism Reviews

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4 August 2017

volume

34

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4 August 2017

issue

3

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4 August 2017

page(s)

565-579

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N-hydroxylation and N-dealkylation by P4502C3 of N-methylbenzamidine: N-oxygenation and N-oxidative dealkylation of one functional group.

4 August 2017

cites work

1 reference

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Microsomal catalyzed N-hydroxylation of guanabenz and reduction of the N-hydroxylated metabolite: characterization of the two reactions and genotoxic potential of guanoxabenz

21 January 2018

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Localization of L-lactate dehydrogenase in mitochondria.

21 January 2018

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An electron-transport system associated with the outer membrane of liver mitochondria. A biochemical and morphological study

21 January 2018

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Immunological similarity between NADH-cytochrome c reductases of mitochondrial outer membrane and microsomes.

21 January 2018

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Cloning, structure, and expression of a cDNA encoding vitamin D3 25-hydroxylase

21 January 2018

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The hydroxylamine reductase of mitochondria

21 January 2018

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Liver microsomal electron transport systems. II. The involvement of cytochrome b5 in the NADH-dependent hydroxylation of 3,4-benzpyrene by a reconstituted cytochrome P-448-containing system.

21 January 2018

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The reduction potential of cytochrome b5 is modulated by its exposed heme edge

21 January 2018

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Enzymic reduction of N-hydroxyamphetamine: the role of electron transfer system containing cytochrome b5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120005643

Reduction of amphetamine hydroxylamine and other aliphatic hydroxylamines by benzamidoxime reductase and human liver microsomes

21 January 2018

1 reference

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On the mechanism of nitric oxide formation upon oxidative cleavage of C = N(OH) bonds by NO-synthases and cytochromes P450.

21 January 2018

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Phase 2 metabolites of N-hydroxylated amidines (amidoximes): synthesis, in vitro formation by pig hepatocytes, and mutagenicity testing

21 January 2018

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Property-based design: optimization of drug absorption and pharmacokinetics

21 January 2018

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Pharmaceutical innovation by the seven UK-owned pharmaceutical companies (1964-1985)

21 January 2018

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Role of the development scientist in compound lead selection and optimization

21 January 2018

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Pharmacokinetics and pharmacodynamics of Ro 44-3888 after single ascending oral doses of sibrafiban, an oral platelet aggregation inhibitor, in healthy male volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120005643

The direct thrombin inhibitor melagatran and its oral prodrug H 376/95: intestinal absorption properties, biochemical and pharmacodynamic effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120005643

Roles of Cytochrome b5in the Oxidation of Testosterone and Nifedipine by Recombinant Cytochrome P450 3A4 and by Human Liver Microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120005643

21 January 2018

Identifiers

DOI

10.1081/DMR-120005643

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4 August 2017

1 reference