(Q34820039)

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Improvement of the skeletal and dental hypophosphatasia phenotype in Alpl-/- mice by administration of soluble (non-targeted) chimeric alkaline phosphatase.

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23 February 2020

Improvement of the skeletal and dental hypophosphatasia phenotype in Alpl-/- mice by administration of soluble (non-targeted) chimeric alkaline phosphatase (English)

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23 February 2020

hypophosphatasia

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Kellen Cristina da Silva Gasque

1

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23 February 2020

8

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23 February 2020

author name string

Brian L Foster

2

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23 February 2020

Pia Kuss

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23 February 2020

Manisha C Yadav

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23 February 2020

Jin Liu

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23 February 2020

Tina Kiffer-Moreira

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23 February 2020

Andrea van Elsas

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23 February 2020

Martha J Somerman

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23 February 2020

José Luis Millán

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23 February 2020

publication date

26 November 2014

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23 February 2020

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23 February 2020

72

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23 February 2020

137-147

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23 February 2020

describes a project that uses

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11 June 2022

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Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis

1 reference

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Pathophysiological role of vascular smooth muscle alkaline phosphatase in medial artery calcification

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Tissue-nonspecific alkaline phosphatase deficiency causes abnormal craniofacial bone development in the Alpl(-/-) mouse model of infantile hypophosphatasia

1 reference

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Catalytic signature of a heat-stable, chimeric human alkaline phosphatase with therapeutic potential.

1 reference

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The rachitic tooth

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The role of phosphatases in the initiation of skeletal mineralization

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Methods for studying tooth root cementum by light microscopy

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8 July 2018

Tooth root dentin mineralization defects in a mouse model of hypophosphatasia

1 reference

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Central role of pyrophosphate in acellular cementum formation

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8 July 2018

Enzyme replacement prevents enamel defects in hypophosphatasia mice

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Thematic series on the pathobiology of vascular calcification: an introduction.

1 reference

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8 July 2018

Dose response of bone-targeted enzyme replacement for murine hypophosphatasia

1 reference

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8 July 2018

The progressive ankylosis protein regulates cementum apposition and extracellular matrix composition

1 reference

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8 July 2018

Rescue of severe infantile hypophosphatasia mice by AAV-mediated sustained expression of soluble alkaline phosphatase

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Vascular pathology of medial arterial calcifications in NT5E deficiency: implications for the role of adenosine in pseudoxanthoma elasticum

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NT5E mutations and arterial calcifications

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PHOSPHO1 is essential for mechanically competent mineralization and the avoidance of spontaneous fractures

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8 July 2018

Enzyme replacement therapy prevents dental defects in a model of hypophosphatasia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283789

8 July 2018

Guidelines for assessment of bone microstructure in rodents using micro-computed tomography

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Beam hardening artifacts in micro-computed tomography scanning can be reduced by X-ray beam filtration and the resulting images can be used to accurately measure BMD.

1 reference

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Mild forms of hypophosphatasia mostly result from dominant negative effect of severe alleles or from compound heterozygosity for severe and moderate alleles

1 reference

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In vivo micro-CT analysis of bone remodeling in a rat calvarial defect model

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8 July 2018

Orodental phenotype and genotype findings in all subtypes of hypophosphatasia

1 reference

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Upregulation of alkaline phosphatase and pyrophosphate hydrolysis: potential mechanism for uremic vascular calcification

1 reference

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Enzyme replacement therapy for murine hypophosphatasia

1 reference

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Novel inhibitors of alkaline phosphatase suppress vascular smooth muscle cell calcification

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Infantile hypophosphatasia: transplantation therapy trial using bone fragments and cultured osteoblasts

1 reference

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8 July 2018

Pyridoxine-responsive seizures as the first symptom of infantile hypophosphatasia caused by two novel missense mutations (c.677T>C, p.M226T; c.1112C>T, p.T371I) of the tissue-nonspecific alkaline phosphatase gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283789

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Vascular smooth muscle cell phenotypic plasticity and the regulation of vascular calcification.

1 reference

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Sustained osteomalacia of long bones despite major improvement in other hypophosphatasia-related mineral deficits in tissue nonspecific alkaline phosphatase/nucleotide pyrophosphatase phosphodiesterase 1 double-deficient mice.

1 reference

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Molecular, endocrine, and genetic mechanisms of arterial calcification

1 reference

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Impaired calcification around matrix vesicles of growth plate and bone in alkaline phosphatase-deficient mice

1 reference

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Marrow cell transplantation for infantile hypophosphatasia

1 reference

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Arterial calcification in diabetes

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Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization

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Abnormal vitamin B6 metabolism in alkaline phosphatase knock-out mice causes multiple abnormalities, but not the impaired bone mineralization

1 reference

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Alkaline phosphatase knock-out mice recapitulate the metabolic and skeletal defects of infantile hypophosphatasia

1 reference

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Correlations of genotype and phenotype in hypophosphatasia

1 reference

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8 July 2018

Identification of fifteen novel mutations in the tissue-nonspecific alkaline phosphatase (TNSALP) gene in European patients with severe hypophosphatasia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283789

8 July 2018

Mice lacking tissue non-specific alkaline phosphatase die from seizures due to defective metabolism of vitamin B-6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283789

8 July 2018

Infantile hypophosphatasia: enzyme replacement therapy by intravenous infusion of alkaline phosphatase-rich plasma from patients with Paget bone disease

1 reference

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8 July 2018

Enzyme replacement therapy for infantile hypophosphatasia attempted by intravenous infusions of alkaline phosphatase-rich Paget plasma: results in three additional patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283789

8 July 2018

Markedly increased circulating pyridoxal-5'-phosphate levels in hypophosphatasia. Alkaline phosphatase acts in vitamin B6 metabolism

1 reference

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8 July 2018

A missense mutation in the human liver/bone/kidney alkaline phosphatase gene causing a lethal form of hypophosphatasia

1 reference

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8 July 2018

Biochemical and morphological effects of human hepatic alkaline phosphatase in a neonate with hypophosphatasia.

1 reference

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8 July 2018

Increased plasma pyridoxal-5'-phosphate levels before and after pyridoxine loading in carriers of perinatal/infantile hypophosphatasia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283789

8 July 2018

Different missense mutations at the tissue-nonspecific alkaline phosphatase gene locus in autosomal recessively inherited forms of mild and severe hypophosphatasia

1 reference

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8 July 2018

Hypophosphatasia - pathophysiology and treatment.

1 reference

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26 October 2018

Enzyme-replacement therapy in life-threatening hypophosphatasia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283789

26 October 2018

Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283789

26 October 2018

Can biological calcification occur in the presence of pyrophosphate?

1 reference

https://pubmed.ncbi.nlm.nih.gov/25433339

12 December 2020

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Identifiers

10.1016/J.BONE.2014.11.017

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Europe PubMed Central

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23 February 2020

1 reference

Europe PubMed Central

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23 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25433339%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

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