(Q34820049)

4 August 2017

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title

The role of WT1 in oncogenesis: tumor suppressor or oncogene? (English)

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4 August 2017

David M Loeb

1

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PubMed ID

12215009

4 August 2017

Saraswati Sukumar

series ordinal

2

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4 August 2017

1 August 2002

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International Journal of Hematology

4 August 2017

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4 August 2017

76

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4 August 2017

117-126

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4 August 2017

2

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https://scigraph.springernature.com/pub.10.1007/bf02982573

4 August 2017

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cites work

Repression of the insulin-like growth factor II gene by the Wilms tumor suppressor WT1

1 reference

12 December 2020

12-O-tetradecanoylphorbol-13-acetate activation of the MDR1 promoter is mediated by EGR1

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12 December 2020

Activation of vitamin D receptor by the Wilms' tumor gene product mediates apoptosis of renal cells

1 reference

12 December 2020

Mutations in the Wilms' tumor gene WT1 in leukemias.

1 reference

12 December 2020

A review of the phenotypic variation due to the Denys-Drash syndrome-associated germline WT1 mutation R362X

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12 December 2020

A novel mutation of the WT1 gene (a tumor suppressor gene for Wilms' tumor) in a patient with Denys-Drash syndrome

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12 December 2020

Wilms' tumor 1 and Dax-1 modulate the orphan nuclear receptor SF-1 in sex-specific gene expression

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12 December 2020

Nuclear localization of the protein encoded by the Wilms' tumor gene WT1 in embryonic and adult tissues

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12 December 2020

Clinical, pathologic, and molecular spectrum of tumors associated with t(11;22)(p13;q12): desmoplastic small round-cell tumor and its variants

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12 December 2020

Expression of the Wilms' tumor gene (WT1) in normal hemopoiesis

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12 December 2020

Expression of the Wilms' tumor gene (WT1) in human leukemias

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12 December 2020

Parental imprinting of the mouse H19 gene

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12 December 2020

Fine structure analysis of the WT1 gene in sporadic Wilms tumors

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12 December 2020

Distinction of eosinophilic leukaemia from idiopathic hypereosinophilic syndrome by analysis of Wilms' tumour gene expression

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12 December 2020

Forced expression of the Wilms tumor 1 (WT1) gene inhibits proliferation of human hematopoietic CD34(+) progenitor cells

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12 December 2020

Identification of DNA methylation markers for human breast carcinomas using the methylation-sensitive restriction fingerprinting technique.

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12 December 2020

The EWS-WT1 translocation product induces PDGFA in desmoplastic small round-cell tumour

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12 December 2020

Cyclin E is a target of WT1 transcriptional repression

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12 December 2020

Chromosome 11 uniparental isodisomy predisposing to embryonal neoplasms

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12 December 2020

Constitutional relaxation of insulin-like growth factor II gene imprinting associated with Wilms' tumour and gigantism

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12 December 2020

Very low frequencies of human normal CD34+ haematopoietic progenitor cells express the Wilms' tumour gene WT1 at levels similar to those in leukaemia cells

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12 December 2020

Immunohistochemical analysis of nuclear versus cytoplasmic staining of WT1 in malignant mesotheliomas and primary pulmonary adenocarcinomas

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12 December 2020

The value of Wilms tumor susceptibility gene 1 in cytologic preparations as a marker for malignant mesothelioma

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12 December 2020

WT-1 is required for early kidney development

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12 December 2020

Wilms' tumor gene product WT1 arrests macrophage differentiation of HL-60 cells through its zinc-finger domain

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12 December 2020

Novel WT1 exon 9 mutation (D396Y) in a patient with early onset Denys Drash syndrome

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12 December 2020

Regulation of nov by WT1: a potential role for nov in nephrogenesis

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12 December 2020

Uniparental paternal disomy in a genetic cancer-predisposing syndrome

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12 December 2020

The Wilms' tumor gene WT1 can regulate genes involved in sex determination and differentiation: SRY, Müllerian-inhibiting substance, and the androgen receptor

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12 December 2020

Evidence for WT1 as a Wilms tumor (WT) gene: intragenic germinal deletion in bilateral WT

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12 December 2020

Methylation changes in promoter and enhancer regions of the WT1 gene in Wilms' tumours

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12 December 2020

Wilms' tumor gene (WT1) competes with differentiation-inducing signal in hematopoietic progenitor cells

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12 December 2020

The Wilms' tumor gene is expressed in a subset of CD34+ progenitors and downregulated early in the course of differentiation in vitro

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12 December 2020

WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis

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12 December 2020

Repression of the transforming growth factor-beta 1 gene by the Wilms' tumor suppressor WT1 gene product

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12 December 2020

The candidate Wilms' tumour gene is involved in genitourinary development

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12 December 2020

WT1 modulates apoptosis by transcriptionally upregulating the bcl-2 proto-oncogene

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12 December 2020

Presence of Wilms' tumor gene (wt1) transcripts and the WT1 nuclear protein in the majority of human acute leukemias

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12 December 2020

Constitutive expression of the Wilms tumor suppressor gene (WT1) in renal cell carcinoma

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12 December 2020

The expression of the Wilms' tumour gene, WT1, in the developing mammalian embryo.

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12 December 2020

Transcriptional activation of the syndecan-1 promoter by the Wilms' tumor protein WT1.

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12 December 2020

A non-AUG translational initiation event generates novel WT1 isoforms

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12 December 2020

WT1-mediated growth suppression of Wilms tumor cells expressing a WT1 splicing variant.

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12 December 2020

Detection of breast cancer cells in ductal lavage fluid by methylation-specific PCR

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12 December 2020

WT1 immunoreactivity in uterine papillary serous carcinomas is different from ovarian serous carcinomas

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12 December 2020

IGF2 is parentally imprinted during human embryogenesis and in the Beckwith-Wiedemann syndrome

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12 December 2020

The Wilms tumor suppressor WT1 encodes a transcriptional activator of amphiregulin

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12 December 2020

Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1

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12 December 2020

Induction of p21 by the Wilms' tumor suppressor gene WT1

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12 December 2020

Analysis of WT1 target gene expression in stably transfected cell lines

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12 December 2020

Homozygous somatic Wt1 point mutations in sporadic unilateral Wilms tumor

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12 December 2020

Wilms' tumor 1 susceptibility (WT1) gene products are selectively expressed in malignant mesothelioma

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12 December 2020

WT1 mutations associated with incomplete Denys-Drash syndrome define a domain predicted to behave in a dominant-negative fashion

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12 December 2020

Expression and mutation analysis of the Wilms' tumor 1 gene in human neural tumors.

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12 December 2020

Detection of the WT1 transcript by RT-PCR in complete remission has no prognostic relevance in de novo acute myeloid leukemia

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12 December 2020

Aniridia-Wilms’ tumor association: evidence for specific deletion of 11p13

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12 December 2020

The Wilms tumor suppressor WT1 directs stage-specific quiescence and differentiation of human hematopoietic progenitor cells

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12 December 2020

Characterization of the genomic breakpoint and chimeric transcripts in the EWS-WT1 gene fusion of desmoplastic small round cell tumor

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12 December 2020

Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus

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12 December 2020

Isolation, characterization, and expression of the murine Wilms' tumor gene (WT1) during kidney development

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12 December 2020

Antagonism of WT1 activity by protein self-association.

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12 December 2020

WT1 mutations contribute to abnormal genital system development and hereditary Wilms' tumour.

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12 December 2020

High levels of Wilms' tumor gene (wt1) mRNA in acute myeloid leukemias are associated with a worse long-term outcome

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12 December 2020

The Wilms' tumor gene product (WT1) modulates the response to 1,25-dihydroxyvitamin D3 by induction of the vitamin D receptor

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12 December 2020

WT1 is an integral component of an antibody panel to distinguish pancreaticobiliary and some ovarian epithelial neoplasms

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12 December 2020

A zinc finger truncation of murine WT1 results in the characteristic urogenital abnormalities of Denys-Drash syndrome

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12 December 2020

Wilms' tumor suppressor gene expression in rat and human mesothelioma.

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12 December 2020

Immunohistochemical detection of the Wilms' tumor gene (WT1) in epithelial ovarian tumors

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12 December 2020

Repression of the retinoic acid receptor-alpha gene by the Wilms' tumor suppressor gene product, wt1.

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12 December 2020

DNA hypermethylation in tumorigenesis: epigenetics joins genetics

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12 December 2020

Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product

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12 December 2020

Altered expression of the WT1 wilms tumor suppressor gene in human breast cancer

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12 December 2020

Wilms' tumor suppressor gene (WT1) is expressed in primary breast tumors despite tumor-specific promoter methylation.

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12 December 2020

E-cadherin is a WT1 target gene

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12 December 2020

Inhibition of colony-stimulating factor-1 promoter activity by the product of the Wilms' tumor locus

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12 December 2020

Germline mutations in the Wilms' tumor suppressor gene are associated with abnormal urogenital development in Denys-Drash syndrome

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12 December 2020

Wilms' tumor (WT1) gene mutations occur mainly in acute myeloid leukemia and may confer drug resistance.

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12 December 2020

Immunity to WT1 in the animal model and in patients with acute myeloid leukemia

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12 December 2020

Epithelial-mesenchymal interactions regulate the stage-specific expression of a cell surface proteoglycan, syndecan, in the developing kidney

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12 December 2020

WT1-mediated transcriptional activation is inhibited by dominant negative mutant proteins.

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12 December 2020

Frasier syndrome is caused by defective alternative splicing of WT1 leading to an altered ratio of WT1 +/-KTS splice isoforms.

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12 December 2020

Mutations of the WT1 gene in childhood nonlymphoid hematological malignancies

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12 December 2020

Fusion of the EWS and WT1 genes in the desmoplastic small round cell tumor

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12 December 2020

Donor splice-site mutations in WT1 are responsible for Frasier syndrome

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12 December 2020

Imprinting of the gene encoding a human cyclin-dependent kinase inhibitor, p57KIP2, on chromosome 11p15

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12 December 2020

Internal translation initiation generates novel WT1 protein isoforms with distinct biological properties

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12 December 2020

Inactivation of WT1 in nephrogenic rests, genetic precursors to Wilms' tumour

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12 December 2020

Novel WT1 mutation (C388Y) in a female child with Denys-Drash syndrome

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12 December 2020

Disruption of insulin-like growth factor 2 imprinting in Beckwith-Wiedemann syndrome

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12 December 2020

Selective elimination of leukemic CD34(+) progenitor cells by cytotoxic T lymphocytes specific for WT1

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12 December 2020

Induction of Rb-associated protein (RbAp46) by Wilms' tumor suppressor WT1 mediates growth inhibition

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12 December 2020

The Wilms' tumor suppressor gene (wt1) product regulates Dax-1 gene expression during gonadal differentiation

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12 December 2020

The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression

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12 December 2020

Hypermethylation of the Wilms' tumor suppressor gene CpG island in human breast carcinomas

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12 December 2020

Mutation analysis of the WT1 gene in secondary leukemia

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12 December 2020

Expression of the wt1 Wilms' tumor gene by normal and malignant human melanocytes

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12 December 2020

A novel missense mutation of the Wt1 gene causing Denys-Drash syndrome with exceptionally mild renal manifestations

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12 December 2020

The EWS gene, involved in Ewing family of tumors, malignant melanoma of soft parts and desmoplastic small round cell tumors, codes for an RNA binding protein with novel regulatory domains

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12 December 2020

Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping

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12 December 2020

Chromosomal imbalance in the Aniridia-Wilms' tumor association: 11p interstitial deletion

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12 December 2020

WT1 as a new prognostic factor and a new marker for the detection of minimal residual disease in acute leukemia.

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12 December 2020

Expression of the Wilms' tumor gene WT1 in the murine urogenital system

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12 December 2020

Zinc finger point mutations within the WT1 gene in Wilms tumor patients

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12 December 2020

Expression of the Wilms' tumor suppressor gene, WT1, is upregulated by leukemia inhibitory factor and induces monocytic differentiation in M1 leukemic cells

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12 December 2020

Midkine as a novel target gene for the Wilms' tumor suppressor gene (WT1).

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12 December 2020

Functional characterization of WT1 binding sites within the human vitamin D receptor gene promoter

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12 December 2020

RNA editing in the Wilms' tumor susceptibility gene, WT1

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12 December 2020

Human platelet-derived growth factor A chain is transcriptionally repressed by the Wilms tumor suppressor WT1

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12 December 2020

Constitutive expression of the Wilms' tumor gene (WT1) in the leukemic cell line U937 blocks parts of the differentiation program

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12 December 2020

Alternative splicing and genomic structure of the Wilms tumor gene WT1

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12 December 2020

The Wilms tumour gene WT1 is expressed in murine mesoderm-derived tissues and mutated in a human mesothelioma

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12 December 2020

HLA class I-restricted lysis of leukemia cells by a CD8(+) cytotoxic T-lymphocyte clone specific for WT1 peptide

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12 December 2020

The Wilms' tumor gene product, WT1, represses transcription of the platelet-derived growth factor A-chain gene

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12 December 2020

Identifiers

DOI

10.1007/BF02982573

1 reference

PubMed ID

12215009

Dimensions Publication ID

4 August 2017

0 references

1 reference

PubMed ID

12215009