(Q34830660)

4 August 2017

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title

Regulation of cytokine signaling and inflammation (English)

1 reference

4 August 2017

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Toshitkatsu Hanada

1

1 reference

PubMed ID

12220554

4 August 2017

Akihiko Yoshimura

series ordinal

2

1 reference

4 August 2017

1 August 2002

1 reference

Cytokine and Growth Factor Reviews

4 August 2017

1 reference

4 August 2017

13

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4 August 2017

413-421

1 reference

4 August 2017

4-5

1 reference

The NF-kappa B and I kappa B proteins: new discoveries and insights

4 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Nuclear factor kappaB/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1beta-stimulated synovial fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

NF-kappaB activation and IkappaB alpha dynamism involved in iNOS and chemokine induction in astroglial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Toll-like receptors: critical proteins linking innate and acquired immunity

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Direct Phosphorylation of IB by IKK and IKK: Discrimination Between Free and NF-B-Bound Substrate

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

AP-1 and NF-kappaB regulation in rheumatoid arthritis and murine collagen-induced arthritis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Interleukin-10 signaling blocks inhibitor of kappaB kinase activity and nuclear factor kappaB DNA binding

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Delivery of IkappaB superrepressor gene with adenovirus reduces early alcohol-induced liver injury in rats

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Adenovirus-mediated expression of a mutant IkappaB kinase 2 inhibits the response of endothelial cells to inflammatory stimuli

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Inhibitor of nuclear factor kappaB kinase beta is a key regulator of synovial inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Possible new role for NF-kappaB in the resolution of inflammation.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

I kappa B-beta regulates the persistent response in a biphasic activation of NF-kappa B

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

A20 blocks endothelial cell activation through a NF-kappaB-dependent mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Regulation of immune responses by TGF-beta

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Transcriptional control by the TGF-beta/Smad signaling system

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

TGF-beta signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Smad6 inhibits signalling by the TGF-beta superfamily.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Blockade of transforming growth factor beta/Smad signaling in T cells by overexpression of Smad7 enhances antigen-induced airway inflammation and airway reactivity

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Cytokine receptor signalling

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

STATs: signal transducers and activators of transcription

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

STATs and gene regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Essential role of Stat6 in IL-4 signalling

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Biological and clinical aspects of interleukin 6.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Up-regulation of the IL-12 receptor beta 2 chain in Crohn's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

IL-6 is required for the development of Th1 cell-mediated murine colitis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Blockade of interleukin 6 trans signaling suppresses T-cell resistanceagainst apoptosis in chronic intestinal inflammation: Evidence in Crohn diseaseand experimental colitis in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Negative regulation of cytokine signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

SOCS proteins: negative regulators of cytokine signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Suppression of STAT5 functions in liver, mammary glands, and T cells in cytokine-inducible SH2-containing protein 1 transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

A new protein containing an SH2 domain that inhibits JAK kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Structure and function of a new STAT-induced STAT inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

A family of cytokine-inducible inhibitors of signalling

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Cloning and characterization of novel CIS family genes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Twenty proteins containing a C-terminal SOCS box form five structural classes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1).

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

The development of fatal myocarditis and polymyositis in mice heterozygous for IFN-gamma and lacking the SOCS-1 gene

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-gamma and IL-4 signaling in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

SOCS3 is essential in the regulation of fetal liver erythropoiesis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Role of the suppressor of cytokine signaling-3 in mediating the inhibitory effects of interleukin-1beta on the growth hormone-dependent transcription of the acid-labile subunit gene in liver cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

LPS and TNFalpha induce SOCS3 mRNA and inhibit IL-6-induced activation of STAT3 in macrophages.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Repeated therapy with monoclonal antibody to tumour necrosis factor alpha (cA2) in patients with rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

Therapy of rheumatoid arthritis by blocking IL-6 signal transduction with a humanized anti-IL-6 receptor antibody

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6101%2802%2900026-6

7 January 2021

10.1016/S1359-6101(02)00026-6

Identifiers

DOI

1 reference

4 August 2017

1 reference

PubMed ID

12220554