(Q34839317)

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N-acetylcysteine amide (NACA) prevents retinal degeneration by up-regulating reduced glutathione production and reversing lipid peroxidation

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scholarly article

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Europe PubMed Central

PubMed publication ID

4 August 2017

N-acetylcysteine amide (NACA) prevents retinal degeneration by up-regulating reduced glutathione production and reversing lipid peroxidation (English)

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

retinal degeneration

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Andrew M Schimel

1

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Linu Abraham

2

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Douglas Cox

3

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Abdoulaye Sene

4

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Courtney Kraus

5

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Dru S Dace

6

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Nuran Ercal

7

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Rajendra S Apte

8

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

language of work or name

0 references

publication date

31 March 2011

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

The American Journal of Pathology

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

178

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

2032-2043

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Reduction of hydrogen peroxide by glutathione peroxidase mimics: reaction mechanism and energetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

N-acetylcysteine amide protects renal proximal tubular epithelial cells against iohexol-induced apoptosis by blocking p38 MAPK and iNOS signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

Retinal light damage: mechanisms and protection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

Involvement of reactive oxygen species in indomethacin-induced apoptosis of small intestinal epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

Increased expression of glutathione peroxidase 4 strongly protects retina from oxidative damage.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

Lipoprotein particles of intraocular origin in human Bruch membrane: an unusual lipid profile

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

Extreme retinal remodeling triggered by light damage: implications for age related macular degeneration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

Morphometric analysis of lipoprotein-like particle accumulation in aging human macular Bruch's membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

Nutritional supplementation in age-related macular degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

Mitochondrial damage and intralysosomal degradation in cellular aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

Reduction of p66Shc suppresses oxidative damage in retinal pigmented epithelial cells and retina

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

Lack of antioxidative properties of vitamin C and pyruvate in cultured retinal pigment epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

Antioxidants reduce cone cell death in a model of retinitis pigmentosa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

A novel antioxidant N-acetylcysteine amide prevents gp120- and Tat-induced oxidative stress in brain endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

Oxidative stress, accumulation of biological 'garbage', and aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

Effects of N-acetylcysteine amide (NACA), a novel thiol antioxidant against glutamate-induced cytotoxicity in neuronal cell line PC12.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

Global data on visual impairment in the year 2002

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

A low molecular weight copper chelator crosses the blood-brain barrier and attenuates experimental autoimmune encephalomyelitis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

The epidemiology of age-related macular degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

A2E, a byproduct of the visual cycle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

Electrophysiological analysis of visual function in mutant mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

Risk factors for age-related macular degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

Oxidants, oxidative stress and the biology of ageing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

The role of oxidative stress in the pathogenesis of age-related macular degeneration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

Oxidative damage and protection of the RPE.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

Morphogenesis of the retinal pigment epithelium: toward understanding retinal degenerative diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

Apoptotic cell death in retinal degenerations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

Measurement of lipid peroxidation

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

https://pubmed.ncbi.nlm.nih.gov/21457933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Morphometric analysis of the choroid, Bruch's membrane, and retinal pigment epithelium in eyes with age-related macular degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

Lipofuscin of the retinal pigment epithelium: a review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

ARPE-19, a human retinal pigment epithelial cell line with differentiated properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

A new microcellular cytotoxicity test based on calcein AM release

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

Analysis of glutathione, glutathione disulfide, cysteine, homocysteine, and other biological thiols by high-performance liquid chromatography following derivatization by n-(1-pyrenyl)maleimide.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

Glutathione depleting agents and lipid peroxidation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

Pathophysiology of age-related macular degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

Cell loss in the aging retina. Relationship to lipofuscin accumulation and macular degeneration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

Growth of cultured RPE and endothelial cells is inhibited by blue light but not green or red light

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

Aging of the human retina. Differential loss of neurons and retinal pigment epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

Senile macular degeneration: a histopathologic study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

8 July 2018

Effects of N-acetylcysteine amide (NACA), a thiol antioxidant on radiation-induced cytotoxicity in Chinese hamster ovary cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

26 October 2018

N-acetylcysteine amide (AD4) attenuates oxidative stress in beta-thalassemia blood cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

26 October 2018

Cigarette smoking, fish consumption, omega-3 fatty acid intake, and associations with age-related macular degeneration: the US Twin Study of Age-Related Macular Degeneration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

26 October 2018

Oxidative damage is a potential cause of cone cell death in retinitis pigmentosa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

26 October 2018

N-acetylcysteine amide, a novel cell-permeating thiol, restores cellular glutathione and protects human red blood cells from oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

26 October 2018

Photoreceptor death, trophic factor expression, retinal oxygen status, and photoreceptor function in the P23H rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

26 October 2018

Nitric oxide and lipid peroxidation are increased and associated with decreased antioxidant enzyme activities in patients with age-related macular degeneration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

26 October 2018

Protection of retinal pigment epithelial cells from oxidative damage by oltipraz, a cancer chemopreventive agent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

26 October 2018

Age-related macular degeneration: review of pathogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

26 October 2018

Light-induced apoptosis: differential timing in the retina and pigment epithelium.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

26 October 2018

Protection of retinal pigment epithelium from oxidative injury by glutathione and precursors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

26 October 2018

Five-year incidence and disappearance of drusen and retinal pigment epithelial abnormalities. Waterman study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3081196

26 October 2018

Potentiation of lead-induced cell death in PC12 cells by glutamate: protection by N-acetylcysteine amide (NACA), a novel thiol antioxidant

1 reference

https://pubmed.ncbi.nlm.nih.gov/21457933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term tolerance to retinal ischemia by repetitive hypoxic preconditioning: role of HIF-1alpha and heme oxygenase-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/21457933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intraretinal oxygen levels before and after photoreceptor loss in the RCS rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/21457933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipofuscin of human retinal pigment epithelium

1 reference

https://pubmed.ncbi.nlm.nih.gov/21457933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Free radical involvement in the oxidate phenomena induced by tert-butyl hydroperoxide in erythrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21457933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comparative evaluation of thiobarbituric acid methods for the determination of malondialdehyde in biological materials

1 reference

https://pubmed.ncbi.nlm.nih.gov/21457933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aging of the human photoreceptor mosaic: evidence for selective vulnerability of rods in central retina

1 reference

https://pubmed.ncbi.nlm.nih.gov/21457933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vitamins, minerals, and macular degeneration. Promising but unproven hypotheses

1 reference

https://pubmed.ncbi.nlm.nih.gov/21457933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Biochemical and histochemical analysis of age related lipid deposits in Bruch's membrane]

1 reference

https://pubmed.ncbi.nlm.nih.gov/21457933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phagocytosis and H2O2 induce catalase and metallothionein gene expression in human retinal pigment epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21457933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of the retinal circulation on vitreal oxygen tension

1 reference

https://pubmed.ncbi.nlm.nih.gov/21457933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathologic features of senile macular degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/21457933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

tert-butyl hydroperoxide kills cultured hepatocytes by peroxidizing membrane lipids

1 reference

https://pubmed.ncbi.nlm.nih.gov/21457933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aging changes in Bruch's membrane. A histochemical and morphologic study

1 reference

https://pubmed.ncbi.nlm.nih.gov/21457933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Photic injury triggers apoptosis of photoreceptor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21457933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related macular degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/21457933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

c-fos controls the "private pathway" of light-induced apoptosis of retinal photoreceptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/21457933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidant-induced apoptosis in cultured human retinal pigment epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21457933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of peroxidized lipids in Bruch's membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/21457933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader

1 reference

https://pubmed.ncbi.nlm.nih.gov/21457933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.AJPATH.2011.01.036

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

ResearchGate publication ID

0 references

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