(Q34856545)

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Strain variations in single amino acids of the 86-kilodalton human cytomegalovirus major immediate-early protein (IE2) affect its functional and biochemical properties: implications of dynamic protein conformation

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Europe PubMed Central

PubMed publication ID

4 August 2017

Strain variations in single amino acids of the 86-kilodalton human cytomegalovirus major immediate-early protein (IE2) affect its functional and biochemical properties: implications of dynamic protein conformation (English)

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Cytomegalovirus

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author name string

M Inmaculada Barrasa

1

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Noam Harel

2

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Europe PubMed Central

PubMed publication ID

4 August 2017

Yongjun Yu

3

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

James C Alwine

4

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Europe PubMed Central

PubMed publication ID

4 August 2017

language of work or name

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publication date

1 April 2003

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Europe PubMed Central

PubMed publication ID

4 August 2017

Journal of Virology

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Europe PubMed Central

PubMed publication ID

4 August 2017

77

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Europe PubMed Central

PubMed publication ID

4 August 2017

8

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

4760-4772

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

Human cytomegalovirus major immediate-early proteins and simian virus 40 large T antigen can inhibit apoptosis through activation of the phosphatidylinositide 3'-OH kinase pathway and the cellular kinase Akt.

1 reference

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Construction of a rationally designed human cytomegalovirus variant encoding a temperature-sensitive immediate-early 2 protein

1 reference

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1 reference

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Covalent modification of the transactivator protein IE2-p86 of human cytomegalovirus by conjugation to the ubiquitin-homologous proteins SUMO-1 and hSMT3b

1 reference

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Effects of human cytomegalovirus major immediate-early proteins in controlling the cell cycle and inhibiting apoptosis: studies with ts13 cells

1 reference

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Binding of the human cytomegalovirus 80-kDa immediate-early protein (IE2) to minor groove A/T-rich sequences bounded by CG dinucleotides is regulated by protein oligomerization and phosphorylation

1 reference

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Phosphorylation of the human cytomegalovirus 86-kilodalton immediate-early protein IE2.

1 reference

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TAF-like functions of human cytomegalovirus immediate-early proteins

1 reference

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The human cytomegalovirus major immediate-early gene

1 reference

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The IE2 regulatory protein of human cytomegalovirus induces expression of the human transforming growth factor beta1 gene through an Egr-1 binding site

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Human cytomegalovirus immediate-early 2 (IE2) protein can transactivate the human hsp70 promoter by alleviation of Dr1-mediated repression

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TAF-like function of SV40 large T antigen

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Identification and mapping of dimerization and DNA-binding domains in the C terminus of the IE2 regulatory protein of human cytomegalovirus

1 reference

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Identification of sequence elements in the human cytomegalovirus DNA polymerase gene promoter required for activation by viral gene products.

1 reference

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Identification of binding sites for the 86-kilodalton IE2 protein of human cytomegalovirus within an IE2-responsive viral early promoter.

1 reference

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A human cytomegalovirus early promoter with upstream negative and positive cis-acting elements: IE2 negates the effect of the negative element, and NF-Y binds to the positive element.

1 reference

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Transcriptional activation by the human cytomegalovirus immediate-early proteins: requirements for simple promoter structures and interactions with multiple components of the transcription complex.

1 reference

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Human cytomegalovirus upregulates NF-kappa B activity by transactivating the NF-kappa B p105/p50 and p65 promoters

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Human cytomegalovirus IE1 and IE2 proteins block apoptosis

1 reference

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Identification and characterization of the human cytomegalovirus immediate-early region 2 gene that stimulates gene expression from an inducible promoter

1 reference

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Autoregulation of the human cytomegalovirus major immediate-early gene

1 reference

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Multiple spliced and unspliced transcripts from human cytomegalovirus immediate-early region 2 and evidence for a common initiation site within immediate-early region 1.

1 reference

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Activation of the U2 snRNA promoter by the octamer motif defines a new class of RNA polymerase II enhancer elements

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Identification of sequence requirements and trans-acting functions necessary for regulated expression of a human cytomegalovirus early gene.

1 reference

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trans-activation and autoregulation of gene expression by the immediate-early region 2 gene products of human cytomegalovirus

1 reference

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Regulated expression of early and late RNAs and proteins from the human cytomegalovirus immediate-early gene region

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Regulation of cytomegalovirus late-gene expression: differential use of three start sites in the transcriptional activation of ICP36 gene expression

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Promoter-specific trans activation and repression by human cytomegalovirus immediate-early proteins involves common and unique protein domains

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Transactivation of a human cytomegalovirus early promoter by gene products from the immediate-early gene IE2 and augmentation by IE1: mutational analysis of the viral proteins

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A discrete cis element in the human immunodeficiency virus long terminal repeat mediates synergistic trans activation by cytomegalovirus immediate-early proteins

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A new approach to protein fold recognition

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Transactivation of the cytomegalovirus ICP36 gene promoter requires the alpha gene product TRS1 in addition to IE1 and IE2

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The 72K IE1 and 80K IE2 proteins of human cytomegalovirus independently trans-activate the c-fos, c-myc and hsp70 promoters via basal promoter elements

1 reference

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The immediate early genes of human cytomegalovirus upregulate expression of the cellular genes myc and fos

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The human cytomegalovirus 80-kilodalton but not the 72-kilodalton immediate-early protein transactivates heterologous promoters in a TATA box-dependent mechanism and interacts directly with TFIID.

1 reference

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In vivo and in vitro analysis of transcriptional activation mediated by the human cytomegalovirus major immediate-early proteins.

1 reference

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26 October 2018

Identifiers

10.1128/JVI.77.8.4760-4772.2003

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

4 August 2017

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