(Q34941187)

5 August 2017

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title

Why do neuroprotective drugs that are so promising in animals fail in the clinic? An industry perspective (English)

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5 August 2017

A Richard Green

1

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5 August 2017

publication date

1 November 2002

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Clinical and Experimental Pharmacology and Physiology

5 August 2017

published in

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5 August 2017

volume

29

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5 August 2017

issue

11

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5 August 2017

page(s)

1030-1034

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5 August 2017

cites work

Epidemiology of stroke

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1681.2002.03767.X

Animal models of stroke: are they relevant to human disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1681.2002.03767.X

Recommendations for standards regarding preclinical neuroprotective and restorative drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1681.2002.03767.X

Delayed treatment with an adenosine kinase inhibitor, GP683, attenuates infarct size in rats with temporary middle cerebral artery occlusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1681.2002.03767.X

Clinical experience with excitatory amino acid antagonist drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1681.2002.03767.X

A comparative assessment of the efficacy and side-effect liability of neuroprotective compounds in experimental stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1681.2002.03767.X

The protective action of chlormethiazole against ischaemia‐induced neurodegeneration in gerbils when infused at doses having little sedative or anticonvulsant activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1681.2002.03767.X

Reversible middle cerebral artery occlusion without craniectomy in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1681.2002.03767.X

Type and extent of hemispheric brain infarctions and clinical outcome in early and delayed middle cerebral artery recanalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1681.2002.03767.X

Effect of NXY-059 on infarct volume after transient or permanent middle cerebral artery occlusion in the rat; studies on dose, plasma concentration and therapeutic time window

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1681.2002.03767.X

Tirilazad reduces cortical infarction after transient but not permanent focal cerebral ischemia in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1681.2002.03767.X

Tissue plasminogen activator for acute ischemic stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1681.2002.03767.X

Thrombolysis of cerebral clot embolism in rat: effect of treatment delay

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1681.2002.03767.X

A comparative analysis of the neuroprotective properties of competitive and uncompetitive N-methyl-D-aspartate receptor antagonists in vivo: implications for the process of excitotoxic degeneration and its therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1681.2002.03767.X

Selfotel in acute ischemic stroke : possible neurotoxic effects of an NMDA antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1681.2002.03767.X

Neuroprotective effects of a novel nitrone, NXY-059, after transient focal cerebral ischemia in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1681.2002.03767.X

Assessment of functional impairment following permanent middle cerebral artery occlusion in a non-human primate species

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1681.2002.03767.X

NXY-059, a free radical--trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1681.2002.03767.X

Long-term functional end points following middle cerebral artery occlusion in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1681.2002.03767.X

Drug development for stroke: importance of protecting cerebral white matter

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1681.2002.03767.X

Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1681.2002.03767.X

Induced hypertension during restoration of flow after temporary middle cerebral artery occlusion in the rat: effect on neuronal injury and edema

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1681.2002.03767.X

Rodent models of cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1681.2002.03767.X

Glycine antagonist in neuroprotection for patients with acute stroke: GAIN Americas: a randomized controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1681.2002.03767.X

The neuroprotective activity of the glycine receptor antagonist GV150526: an in vivo study by magnetic resonance imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1681.2002.03767.X

Longitudinal magnetic resonance imaging study of perfusion and diffusion in stroke: evolution of lesion volume and correlation with clinical outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1681.2002.03767.X

Clomethiazole acute stroke study (CLASS): results of a randomized, controlled trial of clomethiazole versus placebo in 1360 acute stroke patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1681.2002.03767.X

Cerebral blood flow and edema following carotid occlusion in the gerbil

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1681.2002.03767.X

The neuroprotective effect of chlormethiazole on ischaemic neuronal damage following permanent middle cerebral artery ischaemia in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1440-1681.2002.03767.X

10.1046/J.1440-1681.2002.03767.X

21 January 2018

Identifiers

DOI

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5 August 2017

1 reference