(Q34944353)

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The first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity

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scholarly article

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Europe PubMed Central

PubMed publication ID

5 August 2017

The first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity (English)

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

1 reference

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author name string

Meizhen Lou

1

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Thomas P J Garrett

2

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Neil M McKern

3

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Peter A Hoyne

4

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

V Chandana Epa

5

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

John D Bentley

6

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

George O Lovrecz

7

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Leah J Cosgrove

8

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Maurice J Frenkel

9

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Colin W Ward

10

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Europe PubMed Central

PubMed publication ID

5 August 2017

language of work or name

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publication date

7 August 2006

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Proceedings of the National Academy of Sciences of the United States of America

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Europe PubMed Central

PubMed publication ID

5 August 2017

103

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

33

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

12429-12434

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Chiral mutagenesis of insulin. Foldability and function are inversely regulated by a stereospecific switch in the B chain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1533800

8 July 2018

Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1533800

8 July 2018

Insulin and its receptor: structure, function and evolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1533800

8 July 2018

Refinement of macromolecular structures by the maximum-likelihood method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1533800

8 July 2018

Three-dimensional structural interactions of insulin and its receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1533800

8 July 2018

Structural biology of insulin and IGF1 receptors: implications for drug design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1533800

8 July 2018

Comparison of the functional insulin binding epitopes of the A and B isoforms of the insulin receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1533800

8 July 2018

Functional reconstitution of insulin receptor binding site from non-binding receptor fragments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1533800

8 July 2018

Chiral mutagenesis of insulin's hidden receptor-binding surface: structure of an allo-isoleucine(A2) analogue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1533800

8 July 2018

The relationship between the L1 and L2 domains of the insulin and epidermal growth factor receptors and leucine-rich repeat modules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1533800

8 July 2018

Alanine scanning mutagenesis of a type 1 insulin-like growth factor receptor ligand binding site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1533800

8 July 2018

Structure and function of the type 1 insulin-like growth factor receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1533800

8 July 2018

Congenital insulin resistance associated with a conformational alteration in a conserved beta-sheet in the insulin receptor L1 domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1533800

8 July 2018

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1533800

8 July 2018

Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1533800

8 July 2018

A structural switch in a mutant insulin exposes key residues for receptor binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1533800

8 July 2018

Crystallization of the first three domains of the human insulin-like growth factor-1 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1533800

8 July 2018

Identification of common ligand binding determinants of the insulin and insulin-like growth factor 1 receptors. Insights into mechanisms of ligand binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1533800

8 July 2018

Positively charged side chains in the insulin-like growth factor-1 C- and D-regions determine receptor binding specificity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1533800

8 July 2018

Cross-linking of a B25 azidophenylalanine insulin derivative to the carboxyl-terminal region of the alpha-subunit of the insulin receptor. Identification of a new insulin-binding domain in the insulin receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1533800

8 July 2018

Mapping of an NH2-terminal ligand binding site of the insulin receptor by alanine scanning mutagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1533800

8 July 2018

Calculation of electrostatic effects at the amino terminus of an alpha helix

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1533800

8 July 2018

Signaling-competent receptor chimeras allow mapping of major insulin receptor binding domain determinants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1533800

8 July 2018

Replacements of Leucine 87 in Human Insulin Receptor Alter Affinity for Insulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1533800

8 July 2018

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1533800

8 July 2018

Structural analogs of human insulin-like growth factor I with reduced affinity for serum binding proteins and the type 2 insulin-like growth factor receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1533800

8 July 2018

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1533800

8 July 2018

Role of the phenylalanine B24 side chain in directing insulin interaction with its receptor. Importance of main chain conformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1533800

8 July 2018

Deletion analysis of the human insulin receptor ectodomain reveals independently folded soluble subdomains and insulin binding by a monomeric alpha-subunit.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1533800

8 July 2018

Identification of a ligand-binding region of the human insulin receptor encoded by the second exon of the gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1533800

8 July 2018

Improved methods for building protein models in electron density maps and the location of errors in these models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1533800

8 July 2018

Receptor binding redefined by a structural switch in a mutant human insulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1533800

8 July 2018

X-ray analysis of the single chain B29-A1 peptide-linked insulin molecule. A completely inactive analogue.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1533800

8 July 2018

The ligand specificities of the insulin receptor and the insulin-like growth factor I receptor reside in different regions of a common binding site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1533800

8 July 2018

Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1533800

8 July 2018

Identification of determinants that confer ligand specificity on the insulin receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1533800

8 July 2018

Receptor-binding region of insulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1533800

8 July 2018

Diabetes-associated mutations in human insulin: crystal structure and photo-cross-linking studies of a-chain variant insulin Wakayama.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0605395103

21 January 2018

Diabetes-associated mutations in insulin: consecutive residues in the B chain contact distinct domains of the insulin receptor.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0605395103

21 January 2018

How insulin binds: the B-chain alpha-helix contacts the L1 beta-helix of the insulin receptor.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0605395103

21 January 2018

Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0605395103

21 January 2018

Phenol stabilizes more helix in a new symmetrical zinc insulin hexamer

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0605395103

21 January 2018

Specificity of insulin and insulin-like growth factor I receptors investigated using chimeric mini-receptors. Role of C-terminal of receptor alpha subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/16894147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural domains of the insulin receptor and IGF receptor required for dimerisation and ligand binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/16894147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Properties of an insulin receptor with an IGF-1 receptor loop exchange in the cysteine-rich region

1 reference

https://pubmed.ncbi.nlm.nih.gov/16894147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutational analysis of invariant valine B12 in insulin: implications for receptor binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/16894147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Optimizing long intrinsic disorder predictors with protein evolutionary information

1 reference

https://pubmed.ncbi.nlm.nih.gov/16894147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chimeric receptors indicate that phenylalanine 39 is a major contributor to insulin specificity of the insulin receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/16894147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A model for insulin binding to the insulin receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/16894147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation of arginine 86 to proline in the insulin receptor alpha subunit causes lack of transport of the receptor to the plasma membrane, loss of binding affinity and a constitutively activated tyrosine kinase in transfected cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16894147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alanine-scanning mutagenesis of a C-terminal ligand binding domain of the insulin receptor alpha subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/16894147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analog binding properties of insulin receptor mutants. Identification of amino acids interacting with the COOH terminus of the B-chain of the insulin molecule

1 reference

https://pubmed.ncbi.nlm.nih.gov/16894147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alanine scanning mutagenesis of insulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/16894147

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.0605395103

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

2006PNAS..10312429L

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

ResearchGate publication ID

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