(Q34945251)

5 August 2017

title

Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process (English)

1 reference

5 August 2017

1 reference

Rajat Rohatgi

1

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5 August 2017

Ljiljana Milenkovic

series ordinal

2

1 reference

5 August 2017

Ryan B Corcoran

series ordinal

3

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5 August 2017

Matthew P Scott

series ordinal

4

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5 August 2017

language of work or name

English

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publication date

13 February 2009

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Proceedings of the National Academy of Sciences of the United States of America

5 August 2017

published in

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5 August 2017

volume

106

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5 August 2017

issue

9

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5 August 2017

page(s)

3196-3201

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G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling

5 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642660

Beta-arrestin-mediated localization of smoothened to the primary cilium

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642660

Intraflagellar transport, cilia, and mammalian Hedgehog signaling: analysis in mouse embryonic fibroblasts

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642660

Hedgehog regulates smoothened activity by inducing a conformational switch

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642660

Patched1 regulates hedgehog signaling at the primary cilium

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642660

Shifting paradigms in Hedgehog signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642660

Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642660

Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642660

Vertebrate Smoothened functions at the primary cilium

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642660

Communicating with Hedgehogs

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642660

Hedgehog signalling in the mouse requires intraflagellar transport proteins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642660

Mechanisms of resistance to STI571 in Philadelphia chromosome-associated leukemias

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642660

Ligand-selective receptor conformations revisited: the promise and the problem

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642660

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642660

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642660

Small molecule modulation of Smoothened activity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642660

Patched acts catalytically to suppress the activity of Smoothened

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642660

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642660

Activating Smoothened mutations in sporadic basal-cell carcinoma

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642660

A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2642660

Teratogen-mediated inhibition of target tissue response to Shh signaling

8 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0813373106

Targeting the Hedgehog pathway in cancer

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19218434

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0813373106

1 reference

5 August 2017

0 references

1 reference

5 August 2017

1 reference