(Q34966050)

5 August 2017

1 reference

title

Suppression of tumor angiogenesis through the inhibition of integrin function and signaling in endothelial cells: which side to target? (English)

1 reference

ORCID Public Data File 2021

5 August 2017

0 references

1 reference

1 reference

author name string

Rüegg C

series ordinal

1

1 reference

5 August 2017

Dormond O

series ordinal

2

1 reference

5 August 2017

Foletti A

series ordinal

3

1 reference

5 August 2017

publication date

1 January 2002

1 reference

Endothelium: Journal of Endothelial Cell Research

5 August 2017

published in

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5 August 2017

volume

9

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5 August 2017

issue

3

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5 August 2017

page(s)

151-160

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Is angiogenesis inhibition the Holy Grail of cancer therapy?

5 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Identification of a novel class of small-molecule antiangiogenic agents through the screening of combinatorial libraries which function by inhibiting the binding and localization of proteinase MMP2 to integrin alpha(V)beta(3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Requirement of vascular integrin alpha v beta 3 for angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

The regulation of anoikis: MEKK-1 activation requires cleavage by caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Angiogenesis in cancer and other diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

An endotoxin-induced serum factor that causes necrosis of tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Recent advances in research on multistage tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Cellular survival: a play in three Akts

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

NSAIDs inhibit alpha V beta 3 integrin-mediated and Cdc42/Rac-dependent endothelial-cell spreading, migration and angiogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Inhibition of tumor angiogenesis by non-steroidal anti-inflammatory drugs: emerging mechanisms and therapeutic perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

A conserved sequence motif in the integrin beta3 cytoplasmic domain is required for its specific interaction with beta3-endonexin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Integrin alphavbeta3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Rho family proteins in cell adhesion and cell migration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Tumor angiogenesis: therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Angiogenesis in cancer, vascular, rheumatoid and other disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Induction of angiogenesis during the transition from hyperplasia to neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Disruption of epithelial cell-matrix interactions induces apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

21 January 2018

Integrins and anoikis

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

A role for Jun-N-terminal kinase in anoikis; suppression by bcl-2 and crmA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Cell adhesion: old and new questions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Regulation of angiogenesis in vivo by ligation of integrin alpha5beta1 with the central cell-binding domain of fibronectin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Regulation of integrin alpha vbeta 3-mediated endothelial cell migration and angiogenesis by integrin alpha5beta1 and protein kinase A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Src family kinases are required for integrin but not PDGFR signal transduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Integrins and inside-out signal transduction: converging signals from PKC and PIP3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Single subunit chimeric integrins as mimics and inhibitors of endogenous integrin functions in receptor localization, cell spreading and migration, and matrix assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Integrin beta 1- and beta 3-mediated endothelial cell migration is triggered through distinct signaling mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

alpha5beta1 integrin protects intestinal epithelial cells from apoptosis through a phosphatidylinositol 3-kinase and protein kinase B-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

High-dose recombinant tumor necrosis factor alpha in combination with interferon gamma and melphalan in isolation perfusion of the limbs for melanoma and sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Identification of a functionally important sequence in the cytoplasmic tail of integrin beta 3 by using cell-permeable peptide analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Synergy between an antiangiogenic integrin alphav antagonist and an antibody-cytokine fusion protein eradicates spontaneous tumor metastases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

The extracellular matrix as a cell survival factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Sensing the environment: a historical perspective on integrin signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Transplanted cord blood-derived endothelial precursor cells augment postnatal neovascularization

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Disruption of integrin-dependent adhesion and survival of endothelial cells by recombinant adenovirus expressing isolated beta integrin cytoplasmic domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Alpha v integrins as receptors for tumor targeting by circulating ligands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Src deficiency or blockade of Src activity in mice provides cerebral protection following stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

A pilot trial of Vitaxin, a humanized anti-vitronectin receptor (anti alpha v beta 3) antibody in patients with metastatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Mechanisms of angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

NF-kappaB mediates alphavbeta3 integrin-induced endothelial cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Integrins: emerging paradigms of signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

The role of cyclooxygenase inhibition in the antineoplastic effects of nonsteroidal antiinflammatory drugs (NSAIDs)

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Detection of tumor angiogenesis in vivo by alphaVbeta3-targeted magnetic resonance imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

VEGF-D promotes the metastatic spread of tumor cells via the lymphatics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Aspirin use and reduced risk of fatal colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

The integrin linked kinase (ILK) induces an invasive phenotype via AP-1 transcription factor-dependent upregulation of matrix metalloproteinase 9 (MMP-9).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Cyclooxygenase regulates angiogenesis induced by colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

21 January 2018

Cyclooxygenases 1 and 2

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

The role of cyclooxygenases in inflammation, cancer, and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Host cyclooxygenase-2 modulates carcinoma growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Crystal structure of the extracellular segment of integrin alpha Vbeta3

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Vascular-specific growth factors and blood vessel formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Pulse treatment of human vascular endothelial cells with high doses of tumor necrosis factor and interferon-gamma results in simultaneous synergistic and reversible effects on proliferation and morphology

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Integrin-linked kinase (ILK): a "hot" therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

21 January 2018

Focal adhesion assembly

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Integrin-mediated death: an explanation of the integrin-knockout phenotype?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Cell anchorage regulates apoptosis through the retinoblastoma tumor suppressor/E2F pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Transplacental carcinogenesis by stilbestrol

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Definition of Two Angiogenic Pathways by Distinct alpha(v) Integrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Tumor Infarction in Mice by Antibody-Directed Targeting of Tissue Factor to Tumor Vasculature

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Clinical applications of TNF-alpha in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Ceramide mimics tumour necrosis factor-alpha in the induction of cell cycle arrest in endothelial cells. Induction of the tumour suppressor p53 with decrease in retinoblastoma/protein levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Tumor vascular targeting using a tumor-tissue endothelium-specific monoclonal antibody as an effective strategy for cancer chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Resting and activated endothelial cells are increased in the peripheral blood of cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Immunohistochemical analysis of integrin alpha vbeta3 expression on tumor-associated vessels of human carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Vascular endothelial growth factor/vascular permeability factor enhances vascular permeability via nitric oxide and prostacyclin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Angiostatin induces and sustains dormancy of human primary tumors in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Enhanced pathological angiogenesis in mice lacking β3 integrin or β3 and β5 integrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Evidence for the involvement of endothelial cell integrin alphaVbeta3 in the disruption of the tumor vasculature induced by TNF and IFN-gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Vascular targeting as a strategy for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

Circulating activated endothelial cells in sickle cell anemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

p53, vessel count, and vascular endothelial growth factor expression in human colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10623320213635

21 January 2018

Identifiers

DOI

10.1080/10623320213635

1 reference

5 August 2017

1 reference