(Q34975941)

English

Analysis of the mechanism by which the small-molecule CCR5 antagonists SCH-351125 and SCH-350581 inhibit human immunodeficiency virus type 1 entry.

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2 November 2019

Analysis of the mechanism by which the small-molecule CCR5 antagonists SCH-351125 and SCH-350581 inhibit human immunodeficiency virus type 1 entry (English)

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2 November 2019

Alexandra Trkola

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2 November 2019

Thomas P Sakmar

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2 November 2019

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Fotini Tsamis

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2 November 2019

Svetlana Gavrilov

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2 November 2019

Francis Kajumo

3

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2 November 2019

Christoph Seibert

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2 November 2019

Shawn Kuhmann

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2 November 2019

Tom Ketas

6

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2 November 2019

Anadan Palani

8

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2 November 2019

John W Clader

9

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2 November 2019

Jayaram R Tagat

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2 November 2019

Stuart McCombie

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2 November 2019

Bahige Baroudy

12

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2 November 2019

John P Moore

13

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2 November 2019

Tatjana Dragic

15

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2 November 2019

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1 May 2003

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2 November 2019

Journal of Virology

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2 November 2019

77

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2 November 2019

9

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2 November 2019

5201-5208

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2 November 2019

New therapeutics that modulate chemokine networks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153966

8 July 2018

Synthesis, SAR, and biological evaluation of oximino-piperidino-piperidine amides. 1. Orally bioavailable CCR5 receptor antagonists with potent anti-HIV activity

1 reference

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8 July 2018

HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use

1 reference

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8 July 2018

SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153966

8 July 2018

Piperazine-based CCR5 antagonists as HIV-1 inhibitors. II. Discovery of 1-[(2,4-dimethyl-3-pyridinyl)carbonyl]-4- methyl-4-[3(S)-methyl-4-[1(S)-[4-(trifluoromethyl)phenyl]ethyl]-1-piperazinyl]- piperidine N1-oxide (Sch-350634), an orally bioavailabl

1 reference

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8 July 2018

Discovery of 4-[(Z)-(4-bromophenyl)- (ethoxyimino)methyl]-1'-[(2,4-dimethyl-3- pyridinyl)carbonyl]-4'-methyl-1,4'- bipiperidine N-oxide (SCH 351125): an orally bioavailable human CCR5 antagonist for the treatment of HIV infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153966

8 July 2018

Piperazine-based CCR5 antagonists as HIV-1 inhibitors. I: 2(S)-methyl piperazine as a key pharmacophore element

1 reference

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8 July 2018

An overview of the determinants of CCR5 and CXCR4 co-receptor function

1 reference

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8 July 2018

New targets for inhibitors of HIV-1 replication

1 reference

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8 July 2018

Mapping the determinants of the CCR5 amino-terminal sulfopeptide interaction with soluble human immunodeficiency virus type 1 gp120-CD4 complexes

1 reference

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8 July 2018

Global survey of genetic variation in CCR5, RANTES, and MIP-1alpha: impact on the epidemiology of the HIV-1 pandemic.

1 reference

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8 July 2018

HIV chemotherapy

1 reference

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8 July 2018

The effect of genetic variation in chemokines and their receptors on HIV transmission and progression to AIDS.

1 reference

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8 July 2018

Crystal structure of rhodopsin: A G protein-coupled receptor

1 reference

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8 July 2018

Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers

1 reference

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8 July 2018

A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153966

8 July 2018

Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease

1 reference

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8 July 2018

A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153966

8 July 2018

Enhanced inhibition of human immunodeficiency virus type 1 by Met-stromal-derived factor 1beta correlates with down-modulation of CXCR4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153966

8 July 2018

Differential inhibition of human immunodeficiency virus type 1 fusion, gp120 binding, and CC-chemokine activity by monoclonal antibodies to CCR5

1 reference

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8 July 2018

Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function

1 reference

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8 July 2018

Will multiple coreceptors need to be targeted by inhibitors of human immunodeficiency virus type 1 entry?

1 reference

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8 July 2018

CCR5-Mediated human immunodeficiency virus entry depends on an amino-terminal gp120-binding site and on the conformational integrity of all four extracellular domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153966

8 July 2018

N-terminal peptides of stromal cell-derived factor-1 with CXC chemokine receptor 4 agonist and antagonist activities

1 reference

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8 July 2018

Synthetic full-length and truncated RANTES inhibit HIV-1 infection of primary macrophages

1 reference

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8 July 2018

Crystal structure of chemically synthesized [N33A] stromal cell-derived factor 1alpha, a potent ligand for the HIV-1 "fusin" coreceptor

1 reference

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8 July 2018

Reduced HIV-1 infectability of CD4+ lymphocytes from exposed-uninfected individuals: association with low expression of CCR5 and high production of beta-chemokines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153966

8 July 2018

Alanine substitutions of polar and nonpolar residues in the amino-terminal domain of CCR5 differently impair entry of macrophage- and dualtropic isolates of human immunodeficiency virus type 1.

1 reference

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8 July 2018

AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153966

8 July 2018

Genetic subtype-independent inhibition of human immunodeficiency virus type 1 replication by CC and CXC chemokines.

1 reference

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8 July 2018

Amino-terminal substitutions in the CCR5 coreceptor impair gp120 binding and human immunodeficiency virus type 1 entry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153966

8 July 2018

Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4

1 reference

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8 July 2018

Interaction of chemokine receptor CCR5 with its ligands: multiple domains for HIV-1 gp120 binding and a single domain for chemokine binding

1 reference

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8 July 2018

CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro

1 reference

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8 July 2018

Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist.

1 reference

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8 July 2018

Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection

1 reference

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8 July 2018

Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene

1 reference

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8 July 2018

Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153966

8 July 2018

The amino terminus of human CCR5 is required for its function as a receptor for diverse human and simian immunodeficiency virus envelope glycoproteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=153966

26 October 2018

New developments in anti-HIV chemotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/12692222

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/12692222

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemokine receptors and HIV entry

1 reference

https://pubmed.ncbi.nlm.nih.gov/12692222

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/JVI.77.9.5201-5208.2003

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2 November 2019

1 reference

Europe PubMed Central

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2 November 2019

1 reference

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2 November 2019

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