(Q34981135)

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The multivalent effect in glycosidase inhibition: probing the influence of valency, peripheral ligand structure, and topology with cyclodextrin-based iminosugar click clusters.

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scholarly article

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20 February 2020

The multivalent effect in glycosidase inhibition: probing the influence of valency, peripheral ligand structure, and topology with cyclodextrin-based iminosugar click clusters (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24014313%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

Carmen Ortiz Mellet

5

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20 February 2020

author name string

Camille Decroocq

1

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20 February 2020

Antoine Joosten

2

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20 February 2020

Raphaël Sergent

3

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20 February 2020

Teresa Mena Barragán

4

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20 February 2020

Philippe Compain

6

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20 February 2020

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6 September 2013

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20 February 2020

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20 February 2020

14

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20 February 2020

2038-2049

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20 February 2020

15

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20 February 2020

Multivalency as a chemical organization and action principle

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300283

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1 reference

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1 reference

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Glycodendrimers: novel glycotope isosteres unmasking sugar coding. case study with T-antigen markers from breast cancer MUC1 glycoprotein

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Design and creativity in synthesis of multivalent neoglycoconjugates

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Multivalent ligand presentation as a central concept to study intricate carbohydrate-protein interactions

1 reference

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Synthetic multivalent ligands in the exploration of cell-surface interactions

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Entropic Contributions to Rate Accelerations in Enzymic and Intramolecular Reactions and the Chelate Effect

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Stereodivergent access to polyhydroxylated 10-azabicyclo[4.3.1]decanes as new calystegine analogues.

1 reference

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21 January 2018

Synthesis of new beta-1-C-alkylated imino-L-iditols: A comparative study of their activity as beta-glucocerebrosidase inhibitors

1 reference

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21 January 2018

A Fluorescent sp2-iminosugar with pharmacological chaperone activity for gaucher disease: synthesis and intracellular distribution studies

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21 January 2018

Neuronopathic Gaucher's disease: induced pluripotent stem cells for disease modelling and testing chaperone activity of small compounds

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A bicyclic 1-deoxygalactonojirimycin derivative as a novel pharmacological chaperone for GM1 gangliosidosis.

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21 January 2018

Glycosidase inhibition by ring-modified castanospermine analogues: tackling enzyme selectivity by inhibitor tailoring

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21 January 2018

6-Amino-6-deoxy-5,6-di-N-(N'-octyliminomethylidene)nojirimycin: synthesis, biological evaluation, and crystal structure in complex with acid beta-glucosidase

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300283

21 January 2018

Cyclodextrin-mediated crystallization of acid β-glucosidase in complex with amphiphilic bicyclic nojirimycin analogues

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300283

21 January 2018

Glycosidase inhibition with fullerene iminosugar balls: a dramatic multivalent effect.

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300283

21 January 2018

Synthesis and deconvolution of the first combinatorial library of glycosidase inhibitors

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300283

21 January 2018

Multivalent iminosugars to modulate affinity and selectivity for glycosidases.

1 reference

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21 January 2018

Low-generation dendrimers with a calixarene core and based on a chiral C(2)-symmetric pyrrolidine as iminosugar mimics.

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300283

21 January 2018

Synthesis of neoglycoconjugates by transglycosylation with Arthrobacter protophormiae endo-beta-N-acetylglucosaminidase. Demonstration of a macro-cluster effect for mannose-binding proteins

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201300283

21 January 2018

Optimizing saccharide-directed molecular delivery to biological receptors: design, synthesis, and biological evaluation of glycodendrimer-cyclodextrin conjugates

1 reference

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21 January 2018

Exploring and exploiting the therapeutic potential of glycoconjugates

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21 January 2018

Recent developments of transition-state analogue glycosidase inhibitors of non-natural product origin

1 reference

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Iminosugars as therapeutic agents: recent advances and promising trends

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Therapeutic applications of iminosugars: current perspectives and future opportunities

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A counterintuitive approach to treat enzyme deficiencies: use of enzyme inhibitors for restoring mutant enzyme activity

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Pharmacological chaperone therapy for Gaucher disease: a patent review.

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Treating lysosomal storage diseases with pharmacological chaperones: from concept to clinics

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Pharmacological therapy for cystic fibrosis: from bench to bedside

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Rescue of functional delF508-CFTR channels in cystic fibrosis epithelial cells by the alpha-glucosidase inhibitor miglustat

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Discovery of pyrrolo[2,3-b]pyrazines derivatives as submicromolar affinity activators of wild type, G551D, and F508del cystic fibrosis transmembrane conductance regulator chloride channels

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A cystic fibrosis respiratory epithelial cell chronically treated by miglustat acquires a non-cystic fibrosis-like phenotype

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Thermodynamic studies of lectin-carbohydrate interactions by isothermal titration calorimetry

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Cyclodextrin-based multivalent glycodisplays: covalent and supramolecular conjugates to assess carbohydrate-protein interactions.

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Diverse motifs of mannoside clustering on a beta-cyclodextrin core

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