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Reversible behavioral phenotypes in a conditional mouse model of TDP-43 proteinopathies
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4298649
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22 February 2020
title
Reversible behavioral phenotypes in a conditional mouse model of TDP-43 proteinopathies
(English)
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4298649
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22 February 2020
author
Lionel Muller Igaz
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3
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4298649
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22 February 2020
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Julio A Alfieri
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1
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4298649
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22 February 2020
Natalia S Pino
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4298649
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22 February 2020
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1 November 2014
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22 February 2020
published in
Journal of Neuroscience
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4298649
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22 February 2020
volume
34
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22 February 2020
issue
46
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PMC publication ID
4298649
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22 February 2020
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15244-15259
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22 February 2020
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Neuronal sensitivity to TDP-43 overexpression is dependent on timing of induction
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TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes
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Frontotemporal lobar degeneration-related proteins induce only subtle memory-related deficits when bilaterally overexpressed in the dorsal hippocampus
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Cognitive decline typical of frontotemporal lobar degeneration in transgenic mice expressing the 25-kDa C-terminal fragment of TDP-43.
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Core features of frontotemporal dementia recapitulated in progranulin knockout mice
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Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice
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Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis
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Fear conditioning in frontotemporal lobar degeneration and Alzheimer's disease
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TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
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8 July 2018
TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis
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8 July 2018
Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation
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8 July 2018
TDP-43 A315T mutation in familial motor neuron disease
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8 July 2018
TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor
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8 July 2018
Mouse behavioral assays relevant to the symptoms of autism
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8 July 2018
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298649
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8 July 2018
Behavioral characterization in a comprehensive mouse test battery reveals motor and sensory impairments in growth-associated protein-43 null mutant mice
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8 July 2018
Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice
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8 July 2018
Social approach-avoidance behavior of inbred mouse strains towards DBA/2 mice
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8 July 2018
Control of memory formation through regulated expression of a CaMKII transgene
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8 July 2018
Pathological hallmarks of amyotrophic lateral sclerosis/frontotemporal lobar degeneration in transgenic mice produced with TDP-43 genomic fragments
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298649
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26 October 2018
Early and adult hippocampal TGF-β1 overexpression have opposite effects on behavior.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298649
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26 October 2018
Both cytoplasmic and nuclear accumulations of the protein are neurotoxic in Drosophila models of TDP-43 proteinopathies.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298649
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26 October 2018
Intermittent hypoxia during sleep induces reactive gliosis and limited neuronal death in rats: implications for sleep apnea.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298649
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26 October 2018
TDP-43 mutation in familial amyotrophic lateral sclerosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298649
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26 October 2018
Physiologic progesterone reduces mitochondrial dysfunction and hippocampal cell loss after traumatic brain injury in female rats
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298649
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26 October 2018
Stereotypical movements and frontotemporal dementia.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298649
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26 October 2018
Memory consolidation and reconsolidation of an inhibitory avoidance response in mice: effects of i.c.v. injections of hemicholinium-3.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298649
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26 October 2018
Behavioral phenotype of the reeler mutant mouse: effects of RELN gene dosage and social isolation
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298649
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26 October 2018
Synaptic dysfunction in progranulin-deficient mice
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4298649
retrieved
26 October 2018
Identifiers
DOI
10.1523/JNEUROSCI.1918-14.2014
1 reference
stated in
Europe PubMed Central
PMC publication ID
4298649
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25392493%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 February 2020
PMC publication ID
4298649
1 reference
stated in
Europe PubMed Central
PMC publication ID
4298649
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25392493%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 February 2020
PubMed publication ID
25392493
1 reference
stated in
Europe PubMed Central
PMC publication ID
4298649
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25392493%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 February 2020
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