(Q34988349)

5 August 2017

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title

Lymphocide: cytokines and the control of lymphoid homeostasis (English)

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5 August 2017

Annette R Khaled

1

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5 August 2017

Scott K Durum

series ordinal

2

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5 August 2017

language of work or name

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1 November 2002

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Nature Reviews Immunology

5 August 2017

published in

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5 August 2017

volume

2

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5 August 2017

issue

11

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5 August 2017

page(s)

817-830

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5 August 2017

cites work

Lymphocyte homeostasis

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The organization of mature T-cell pools

31 March 2020

1 reference

Peripheral T lymphocytes: expansion potential and homeostatic regulation of pool sizes and CD4/CD8 ratios in vivo

31 March 2020

1 reference

Homeostatic expansion and phenotypic conversion of naïve T cells in response to self peptide/MHC ligands

31 March 2020

1 reference

Population biology of lymphocytes: the flight for survival

31 March 2020

1 reference

Homeostasis of alpha beta TCR+ T cells.

31 March 2020

1 reference

The life span of naive alpha/beta T cells in secondary lymphoid organs

31 March 2020

1 reference

IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation

31 March 2020

1 reference

Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice

31 March 2020

1 reference

IL-7 is critical for homeostatic proliferation and survival of naive T cells

31 March 2020

1 reference

Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

31 March 2020

1 reference

Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells

31 March 2020

1 reference

Overexpression of interleukin (IL)-7 leads to IL-15-independent generation of memory phenotype CD8+ T cells

31 March 2020

1 reference

Homeostatic T cell proliferation in a T cell-dendritic cell coculture system

31 March 2020

1 reference

An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent Pathway

31 March 2020

1 reference

How alpha beta T cells deal with induced TCR alpha ablation

31 March 2020

1 reference

In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death.

31 March 2020

1 reference

Homeostatic expansion occurs independently of costimulatory signals

31 March 2020

1 reference

The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity

31 March 2020

1 reference

Molecular mechanisms of activated T cell death in vivo

31 March 2020

1 reference

Mechanisms of TGF-beta-mediated apoptosis

31 March 2020

1 reference

Transforming growth factor-beta in T-cell biology

31 March 2020

1 reference

Defective lymphoid development in mice lacking Jak3

31 March 2020

1 reference

Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death

31 March 2020

1 reference

Interleukin‐7 induces the association of phosphatidylinositol 3‐kinase with the α chain of the interleukin‐7 receptor

31 March 2020

1 reference

Control of T cell development in vivo by subdomains within the IL-7 receptor alpha-chain cytoplasmic tail

31 March 2020

1 reference

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

31 March 2020

1 reference

Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.

31 March 2020

1 reference

Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration

31 March 2020

1 reference

Evidence for phosphatidylinositol 3-kinase-dependent T cell antigen receptor (TCR) signal transduction

31 March 2020

1 reference

Phosphoinositide 3-kinase regulation of T cell receptor-mediated interleukin-2 gene expression in normal T cells

31 March 2020

1 reference

31 March 2020

1 reference

Expression of Active Protein Kinase B in T Cells Perturbs Both T and B Cell Homeostasis and Promotes Inflammation

31 March 2020

1 reference

Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology

31 March 2020

1 reference

NF-kappa B activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development

31 March 2020

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NF-kappaB at the crossroads of life and death

31 March 2020

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The combined absence of NF-kappa B1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells

31 March 2020

1 reference

Energy metabolism during apoptosis. Bcl-2 promotes survival in hematopoietic cells induced to apoptose by growth factor withdrawal by stabilizing a form of metabolic arrest

31 March 2020

1 reference

A role for the serine/threonine kinase, Akt, in insulin-stimulated glucose uptake

31 March 2020

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Cell metabolism in the regulation of programmed cell death

31 March 2020

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Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

31 March 2020

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Growth factors can influence cell growth and survival through effects on glucose metabolism

31 March 2020

1 reference

The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis

31 March 2020

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Mitochondria as the central control point of apoptosis

31 March 2020

1 reference

pHi regulatory ion transporters: an update on structure, regulation and cell function

31 March 2020

1 reference

p90(RSK) is a serum-stimulated Na+/H+ exchanger isoform-1 kinase. Regulatory phosphorylation of serine 703 of Na+/H+ exchanger isoform-1

31 March 2020

1 reference

14-3-3 Binding to Na+/H+ exchanger isoform-1 is associated with serum-dependent activation of Na+/H+ exchange

31 March 2020

1 reference

Trophic factor withdrawal: p38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinization

31 March 2020

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Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase

31 March 2020

1 reference

IL-7 withdrawal induces a stress pathway activating p38 and Jun N-terminal kinases

31 March 2020

1 reference

p38 Kinase is a negative regulator of angiotensin II signal transduction in vascular smooth muscle cells: effects on Na+/H+ exchange and ERK1/2

31 March 2020

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Interleukin-3 withdrawal induces an early increase in mitochondrial membrane potential unrelated to the Bcl-2 family. Roles of intracellular pH, ADP transport, and F(0)F(1)-ATPase

31 March 2020

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Withdrawal of IL-7 induces Bax translocation from cytosol to mitochondria through a rise in intracellular pH.

31 March 2020

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Apoptosis induced by IL-2 withdrawal is associated with an intracellular acidification

31 March 2020

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Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis

31 March 2020

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Activation of a low pH-dependent nuclease by apoptotic agents

31 March 2020

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Cytochrome c maintains mitochondrial transmembrane potential and ATP generation after outer mitochondrial membrane permeabilization during the apoptotic process

31 March 2020

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Caspases disrupt mitochondrial membrane barrier function.

31 March 2020

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BCL-2 family: regulators of cell death

31 March 2020

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Regulation of lymphocyte survival by the bcl-2 gene family

31 March 2020

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Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

31 March 2020

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The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry

31 March 2020

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Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

31 March 2020

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Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

31 March 2020

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bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

31 March 2020

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Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival

31 March 2020

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Expression of cyclin D1 in epithelial tissues of transgenic mice results in epidermal hyperproliferation and severe thymic hyperplasia

31 March 2020

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Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice

31 March 2020

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Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice

31 March 2020

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Essential requirement for c-kit and common gamma chain in thymocyte development cannot be overruled by enforced expression of Bcl-2.

31 March 2020

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Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

31 March 2020

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Movement of Bax from the cytosol to mitochondria during apoptosis

31 March 2020

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Regulated targeting of BAX to mitochondria.

31 March 2020

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Bax-deficient mice with lymphoid hyperplasia and male germ cell death

31 March 2020

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Jak3 selectively regulates Bax and Bcl-2 expression to promote T-cell development

31 March 2020

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Bax deficiency partially corrects interleukin-7 receptor alpha deficiency

31 March 2020

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The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

31 March 2020

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Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

31 March 2020

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Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation

31 March 2020

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Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

31 March 2020

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BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

31 March 2020

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Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

31 March 2020

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Bad can act as a key regulator of T cell apoptosis and T cell development.

31 March 2020

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31 March 2020

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Divinations and surprises: genetic analysis of caspase function in mice

31 March 2020

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Caspase enzyme activity is not essential for apoptosis during thymocyte development

31 March 2020

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Inactivating mutations of CASP10 gene in non-Hodgkin lymphomas.

31 March 2020

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Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

31 March 2020

1 reference

Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis

31 March 2020

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The mitochondrial apoptosome: a killer unleashed by the cytochrome seas

31 March 2020

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Regulation of cell death protease caspase-9 by phosphorylation

31 March 2020

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Differential requirement for caspase 9 in apoptotic pathways in vivo.

31 March 2020

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The apoptotic protease-activating factor 1-mediated pathway of apoptosis is dispensable for negative selection of thymocytes.

31 March 2020

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Caspase-independent apoptotic pathways in T lymphocytes: a minireview

31 March 2020

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Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

31 March 2020

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Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction

31 March 2020

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IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

31 March 2020

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Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

31 March 2020

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Characterization of XIAP-deficient mice

31 March 2020

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IL-7 administration alters the CD4:CD8 ratio, increases T cell numbers, and increases T cell function in the absence of activation

31 March 2020

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IL-7 increases both thymic-dependent and thymic-independent T-cell regeneration after bone marrow transplantation

31 March 2020

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Interleukin 7 receptor-deficient mice lack gammadelta T cells

31 March 2020

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Defective T-cell receptor gamma gene rearrangement in interleukin-7 receptor knockout mice

31 March 2020

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TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease

31 March 2020

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Regulation of naïve and memory T-cell homeostasis

31 March 2020

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31 March 2020

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IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice

31 March 2020

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Cutaneous lymphoproliferation and lymphomas in interleukin 7 transgenic mice

31 March 2020

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IL-7 transgenic mice: analysis of the role of IL-7 in the differentiation of thymocytes in vivo and in vitro

31 March 2020

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Fatal leukemia in interleukin 15 transgenic mice follows early expansions in natural killer and memory phenotype CD8+ T cells.

31 March 2020

1 reference

Peripheral expression of Jak3 is required to maintain T lymphocyte function

31 March 2020

1 reference

IL-3 dependent regulation of Bcl-xL gene expression by STAT5 in a bone marrow derived cell line

31 March 2020

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NF-kappaB activates Bcl-2 expression in t(14;18) lymphoma cells

31 March 2020

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Protein kinase B (Akt) regulation and function in T lymphocytes

31 March 2020

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Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

31 March 2020

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Cellular damage signals promote sequential changes at the N-terminus and BH-1 domain of the pro-apoptotic protein Bak.

31 March 2020

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Bim: a novel member of the Bcl-2 family that promotes apoptosis

31 March 2020

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The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

31 March 2020

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Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

31 March 2020

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Activation of mitochondrial voltage-dependent anion channel by apro-apoptotic BH3-only protein Bim

31 March 2020

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Early transitory rise in intracellular pH leads to Bax conformation change during ceramide-induced apoptosis

31 March 2020

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The phosphatidylinositol 3-kinase (PI3K)-Akt pathway suppresses Bax translocation to mitochondria

31 March 2020

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Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

31 March 2020

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Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis

31 March 2020

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BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

31 March 2020

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BAX-dependent transport of cytochrome c reconstituted in pure liposomes

31 March 2020

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Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

31 March 2020

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The molecular basis of X-linked severe combined immunodeficiency: defective cytokine receptor signaling

31 March 2020

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Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

31 March 2020

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Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

31 March 2020

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Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells

31 March 2020

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Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3

31 March 2020

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BAFFled B cells survive and thrive: roles of BAFF in B-cell development

31 March 2020

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A role for FADD in T cell activation and development

31 March 2020

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T cell-specific FADD-deficient mice: FADD is required for early T cell development

31 March 2020

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Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase.

31 March 2020

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Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

31 March 2020

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T cells from baxalpha transgenic mice show accelerated apoptosis in response to stimuli but do not show restored DNA damage-induced cell death in the absence of p53.

31 March 2020

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Development and proliferation of lymphocytes in mice deficient for both interleukins-2 and -4

31 March 2020

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Retroviral transduction of enriched hematopoietic stem cells allows lifelong Bcl-2 expression in multiple lineages but does not perturb hematopoiesis

31 March 2020

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Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

31 March 2020

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Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease

31 March 2020

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Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI931

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Dimensions Publication ID

5 August 2017

1023249733

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