(Q35004513)

5 August 2017

title

Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage (English)

1 reference

5 August 2017

Scott R Kennedy

1

1 reference

5 August 2017

Jesse J Salk

series ordinal

2

1 reference

5 August 2017

Michael W Schmitt

series ordinal

3

1 reference

5 August 2017

Lawrence A Loeb

series ordinal

4

1 reference

5 August 2017

publication date

26 September 2013

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5 August 2017

1 reference

5 August 2017

volume

9

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5 August 2017

issue

9

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5 August 2017

page(s)

e1003794

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Creative Commons Attribution 4.0 International

5 August 2017

copyright license

start time

26 September 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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8 July 2018

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8 July 2018

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Somatic mutations in aging, cancer and neurodegeneration

8 July 2018

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8 July 2018

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Human cancers express mutator phenotypes: origin, consequences and targeting

8 July 2018

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Ultra-deep sequencing of mouse mitochondrial DNA: mutational patterns and their origins

8 July 2018

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Heteroplasmic mitochondrial DNA mutations in normal and tumour cells

8 July 2018

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Mutational heterogeneity in human cancers: origin and consequences.

8 July 2018

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Automated inference of molecular mechanisms of disease from amino acid substitutions.

8 July 2018

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Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice.

8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784509

Fast and accurate short read alignment with Burrows-Wheeler transform

8 July 2018

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Evaluation of next generation sequencing platforms for population targeted sequencing studies

8 July 2018

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An enhanced MITOMAP with a global mtDNA mutational phylogeny

8 July 2018

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Induction of parkin expression in the presence of oxidative stress.

8 July 2018

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High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784509

Mutation hot spots in mammalian mitochondrial DNA.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784509

Replication of mitochondrial DNA occurs by strand displacement with alternative light-strand origins, not via a strand-coupled mechanism

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784509

Mitochondrial DNA mutations in human disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784509

Decline in skeletal muscle mitochondrial function with aging in humans

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784509

DNA precursor asymmetries in mammalian tissue mitochondria and possible contribution to mutagenesis through reduced replication fidelity.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784509

Aging: a theory based on free radical and radiation chemistry

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784509

Oxidative DNA damage: mechanisms, mutation, and disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784509

Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784509

High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784509

Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: analysis by laser-capture microdissection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784509

In vivo functional analysis of the human mitochondrial DNA polymerase POLG expressed in cultured human cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784509

Oxyradicals and DNA damage

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784509

Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784509

Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784509

Mitochondrial mutagenesis in human cells and tissues

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784509

Pattern of nucleotide substitution and rate heterogeneity in the hypervariable regions I and II of human mtDNA

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784509

Age-associated increase in 8-oxo-deoxyguanosine glycosylase/AP lyase activity in rat mitochondria

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784509

Mitochondrial diseases in man and mouse

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784509

The free radical theory of aging matures

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784509

Oxidized, deaminated cytosines are a source of C --> T transitions in vivo

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784509

Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784509

Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784509

Replication of animal mitochondrial DNA.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784509

The biologic clock: the mitochondria?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784509

Inosine induced mutations.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784509

Dynamics of mitochondrial DNA evolution in animals: amplification and sequencing with conserved primers

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784509

Genetic effects of thymine glycol: site-specific mutagenesis and molecular modeling studies

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784509

Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784509

A sensitive genetic assay for the detection of cytosine deamination: determination of rate constants and the activation energy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784509

8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784509

Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784509

Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons

8 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003794

Mitochondrial DNA deletions and the aging heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003794

Mitochondrial DNA deletions/rearrangements in parkinson disease and related neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003794

Mitochondrial point mutations do not limit the natural lifespan of mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003794

Quantification of random mutations in the mitochondrial genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003794

Origins of human mitochondrial point mutations as DNA polymerase gamma-mediated errors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003794

Substitution rate variation among sites in hypervariable region 1 of human mitochondrial DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003794

Asymmetrical directional mutation pressure in the mitochondrial genome of mammals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003794

An investigation of the variation in the transition bias among various animal mitochondrial DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003794

Lack of the DNA glycosylases MYH and OGG1 in the cancer prone double mutant mouse does not increase mitochondrial DNA mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003794

Mitochondrial glutathione oxidation correlates with age-associated oxidative damage to mitochondrial DNA.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3784509

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

26 October 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003794

Mutagenic deamination of cytosine residues in DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003794

Differences in the accumulation of mitochondrial defects with age in mice and humans

21 January 2018

1 reference

12 December 2020

Incorporation and replication of 8-oxo-deoxyguanosine by the human mitochondrial DNA polymerase

1 reference

12 December 2020

The fidelity of human DNA polymerase gamma with and without exonucleolytic proofreading and the p55 accessory subunit

1 reference

12 December 2020

Marked changes in mitochondrial DNA deletion levels in Alzheimer brains

1 reference

12 December 2020

Strand asymmetry in human mitochondrial DNA mutations

1 reference

12 December 2020

Correlation between mitochondrial DNA 4977-bp deletion and respiratory chain enzyme activities in aging human skeletal muscles

1 reference

12 December 2020

Age-dependent respiratory function decline and DNA deletions in human muscle mitochondria

1 reference

12 December 2020

The free-radical theory of ageing--older, wiser and still alive: modelling positional effects of the primary targets of ROS reveals new support

1 reference

12 December 2020

10.1371/JOURNAL.PGEN.1003794

Identifiers

DOI

1 reference

release_jxb4bgdminbypc6fo7corcuwbu

5 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/jxb4bgdminbypc6fo7corcuwbu

24 November 2022

mapped directly with Wikidata item

PMC publication ID

3784509

1 reference

5 August 2017

1 reference