(Q35012107)

5 August 2017

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title

Pharmacological and biological aspects of basic research on nucleoside-based reverse transcriptase inhibitors (English)

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5 August 2017

B Macchi

1

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5 August 2017

A Mastino

series ordinal

2

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5 August 2017

publication date

1 December 2002

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5 August 2017

published in

Pharmacological Research

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5 August 2017

volume

46

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5 August 2017

issue

6

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5 August 2017

page(s)

473-482

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Antiviral drugs: current state of the art.

5 August 2017

cites work

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7 January 2021

Resistance of human immunodeficiency virus type 1 to reverse transcriptase and protease inhibitors: genotypic and phenotypic testing

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7 January 2021

Antiretroviral therapeutic possibilities for human immunodeficiency virus/acquired immunodeficiency syndrome.

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7 January 2021

RNA-dependent DNA polymerase in virions of RNA tumour viruses

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7 January 2021

Phosphorylation of nucleoside analog antiretrovirals: a review for clinicians

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7 January 2021

https://api.crossref.org/works/10.1016%2FS1043661802002128

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Differential phosphorylation of azidothymidine, dideoxycytidine, and dideoxyinosine in resting and activated peripheral blood mononuclear cells

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7 January 2021

The bottleneck in AZT activation

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7 January 2021

Decreased thymidine kinase levels in peripheral blood cells from HIV-seropositive individuals: implications for zidovudine metabolism.

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7 January 2021

Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease

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7 January 2021

Intrathecal synthesis of IgG antibodies to HTLV-I supports an etiological role for HTLV-I in tropical spastic paraparesis

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7 January 2021

Treatment of Adult T-Cell Leukemia-Lymphoma with Zidovudine and Interferon Alfa

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7 January 2021

Long-term, high dose interferon-alpha treatment in HTLV-I-associated myelopathy/tropical spastic paraparesis: a combined clinical, virological and immunological study

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7 January 2021

Effect of lamivudine on human T-cell leukemia virus type 1 (HTLV-1) DNA copy number, T-cell phenotype, and anti-tax cytotoxic T-cell frequency in patients with HTLV-1-associated myelopathy

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7 January 2021

Profound suppression of hepatitis B virus replication with lamivudine

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7 January 2021

Pharmacological inhibition of in vitro infectivity of human T lymphotropic virus type I

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7 January 2021

AZT inhibits the transmission of human T cell leukaemia/lymphoma virus type I to adult peripheral blood mononuclear cells in vitro

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7 January 2021

Efficacy of 3'-azido 3'deoxythymidine (AZT) in preventing HTLV-1 transmission to human cord blood mononuclear cells.

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7 January 2021

3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro

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7 January 2021

Plasma and cerebrospinal fluid pharmacokinetics of 3'-azido-3'-deoxythymidine: a novel pyrimidine analog with potential application for the treatment of patients with AIDS and related diseases

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7 January 2021

Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) by 2',3'-dideoxynucleosides

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7 January 2021

Didanosine. A review of its antiviral activity, pharmacokinetic properties and therapeutic potential in human immunodeficiency virus infection

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7 January 2021

Pharmacokinetics of didanosine in patients with acquired immunodeficiency syndrome or acquired immunodeficiency syndrome-related complex.

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7 January 2021

Anti-human immunodeficiency virus type 1 activity and in vitro toxicity of 2'-deoxy-3'-thiacytidine (BCH-189), a novel heterocyclic nucleoside analog

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7 January 2021

(-)-2'-deoxy-3'-thiacytidine is a potent, highly selective inhibitor of human immunodeficiency virus type 1 and type 2 replication in vitro

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7 January 2021

Cellular factors involved in the induction of resistance of HIV to antiretroviral agents.

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7 January 2021

Long-term exposure to zidovudine affects in vitro and in vivo the efficiency of phosphorylation of thymidine kinase

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7 January 2021

Cellular pharmacology of 2',3'-didehydro-2',3'-dideoxythymidine (D4T) in human peripheral blood mononuclear cells

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7 January 2021

Genetic risks of antiviral nucleoside analogues--a survey

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7 January 2021

Genotoxic activity of azidothymidine (AZT) in in vitro systems

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7 January 2021

Genotoxicity of 3'-azido-3'-deoxythymidine in the human lymphoblastoid cell line, TK6: relationships between DNA incorporation, mutant frequency, and spectrum of deletion mutations in HPRT

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https://api.crossref.org/works/10.1016%2FS1043661802002128

7 January 2021

Relationships between DNA incorporation, mutant frequency, and loss of heterozygosity at the TK locus in human lymphoblastoid cells exposed to 3'-azido-3'-deoxythymidine

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https://api.crossref.org/works/10.1016%2FS1043661802002128

7 January 2021

Nonclinical toxicology studies with zidovudine: genetic toxicity tests and carcinogenicity bioassays in mice and rats

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7 January 2021

3'-azido-3'-deoxythymidine (AZT) transplacental perfusion kinetics and DNA incorporation in normal human placentas perfused with AZT

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https://api.crossref.org/works/10.1016%2FS1043661802002128

7 January 2021

Incorporation of zidovudine into leukocyte DNA from HIV-1-positive adults and pregnant women, and cord blood from infants exposed in utero

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https://api.crossref.org/works/10.1016%2FS1043661802002128

7 January 2021

Transplacental effects of 3'-azido-2',3'-dideoxythymidine (AZT): tumorigenicity in mice and genotoxicity in mice and monkeys

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https://api.crossref.org/works/10.1016%2FS1043661802002128

7 January 2021

Zidovudine-didanosine coexposure potentiates DNA incorporation of zidovudine and mutagenesis in human cells

1 reference

https://api.crossref.org/works/10.1016%2FS1043661802002128

7 January 2021

Nucleosides. V. The Monomesylates of 1-(2'-Deoxy-β-D-lyxofuranosyl)thymine1,2

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7 January 2021

Maximum tolerable doses of intravenous zidovudine in combination with 5-fluorouracil and leucovorin in metastatic colorectal cancer patients. Clinical evidence of significant antitumor activity and enhancement of zidovudine-induced DNA single strand

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7 January 2021

Doses and time-dependent effects of 3'-azido-3'-deoxythymidine on T47D human breast cancer cells in vitro

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https://api.crossref.org/works/10.1016%2FS1043661802002128

7 January 2021

Chronic in vitro exposure to 3'-azido-2', 3'-dideoxythymidine induces senescence and apoptosis and reduces tumorigenicity of metastatic mouse mammary tumor cells

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https://api.crossref.org/works/10.1016%2FS1043661802002128

7 January 2021

Effect of lamivudine on transmission of human T-cell lymphotropic virus type 1 to adult peripheral blood mononuclear cells in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1043661802002128

7 January 2021

Azidothymidine inhibits mitogen stimulated growth and DNA-repair in human peripheral lymphocytes

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https://api.crossref.org/works/10.1016%2FS1043661802002128

7 January 2021

Inhibition of immune functions by antiviral drugs

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https://api.crossref.org/works/10.1016%2FS1043661802002128

7 January 2021

Down-Regulation of Interleukin-2 Receptor Gene Activation and Protein Expression by Dideoxynucleoside Analogs

1 reference

https://api.crossref.org/works/10.1016%2FS1043661802002128

7 January 2021

Synchronization of cells in the S phase of the cell cycle by 3'-azido-3'-deoxythymidine: implications for cell cytotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS1043661802002128

7 January 2021

Interference with cell cycle progression and induction of apoptosis by dideoxynucleoside analogs

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https://api.crossref.org/works/10.1016%2FS1043661802002128

7 January 2021

Potentiation of Azidothymidine Cytotoxicity in Cisplatin-resistant Human Ovarian Carcinoma Cells

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https://api.crossref.org/works/10.1016%2FS1043661802002128

7 January 2021

Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines

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https://api.crossref.org/works/10.1016%2FS1043661802002128

7 January 2021

Deoxyribonucleotide analogs as inhibitors and substrates of DNA polymerases

1 reference

https://api.crossref.org/works/10.1016%2FS1043661802002128

7 January 2021

Control of apoptosis by the cellular ATP level

1 reference

https://api.crossref.org/works/10.1016%2FS1043661802002128

7 January 2021

Comparison of mitochondrial morphology, mitochondrial DNA content, and cell viability in cultured cells treated with three anti-human immunodeficiency virus dideoxynucleosides

1 reference

https://api.crossref.org/works/10.1016%2FS1043661802002128

7 January 2021

Direct analysis of mitochondrial toxicity of antiretroviral drugs

1 reference

https://api.crossref.org/works/10.1016%2FS1043661802002128

7 January 2021

10.1016/S1043661802002128

Identifiers

DOI

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5 August 2017

1 reference