(Q35032512)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25247810%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

title

Identification of amino acid determinants in CYP4B1 for optimal catalytic processing of 4-ipomeanol (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25247810%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25247810%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

Vladimir Yarov-Yarovoy

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25247810%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

author name string

Constanze Wiek

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25247810%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

Eva M Schmidt

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25247810%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

Katharina Roellecke

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25247810%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

Marcel Freund

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25247810%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

Mariko Nakano

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25247810%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

Edward J Kelly

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25247810%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

Christof M Kramm

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25247810%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

Allan E Rettie

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25247810%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

Helmut Hanenberg

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25247810%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

language of work or name

English

0 references

publication date

1 January 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25247810%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25247810%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

volume

465

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25247810%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25247810%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

page(s)

103-114

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25247810%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

17 February 2020

1 reference

10 June 2022

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pmc&rettype=xml&id=4312185

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Generation and characterization of a Cyp4b1 null mouse and the role of CYP4B1 in the activation and toxicity of Ipomeanol

8 July 2018

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CYP4 enzymes as potential drug targets: focus on enzyme multiplicity, inducers and inhibitors, and therapeutic modulation of 20-hydroxyeicosatetraenoic acid (20-HETE) synthase and fatty acid ω-hydroxylase activities

8 July 2018

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Structural diversity of eukaryotic membrane cytochrome p450s

8 July 2018

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8 July 2018

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8 July 2018

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Human cytochromes P450 in health and disease

8 July 2018

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CYP4V2 in Bietti's crystalline dystrophy: ocular localization, metabolism of ω-3-polyunsaturated fatty acids, and functional deficit of the p.H331P variant

8 July 2018

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Evolution of cytochrome p450 genes from the viewpoint of genome informatics

8 July 2018

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Rearrangement reactions catalyzed by cytochrome P450s

8 July 2018

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Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2

8 July 2018

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Xenobiotic-metabolizing enzymes in human lung

8 July 2018

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Homology modeling using parametric alignment ensemble generation with consensus and energy-based model selection

8 July 2018

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CYP4B1: an enigmatic P450 at the interface between xenobiotic and endobiotic metabolism

8 July 2018

1 reference

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Woodchuck hepatitis virus post-transcriptional regulatory element deleted from X protein and promoter sequences enhances retroviral vector titer and expression

8 July 2018

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FMDV-2A sequence and protein arrangement contribute to functionality of CYP2B1-reporter fusion protein

8 July 2018

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8 July 2018

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Protein structure prediction and analysis using the Robetta server.

8 July 2018

1 reference

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Cytochromes P450: a success story

8 July 2018

1 reference

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CYP4B1 is a possible risk factor for bladder cancer in humans

8 July 2018

1 reference

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Identification of the binding site on cytochrome P450 2B4 for cytochrome b5 and cytochrome P450 reductase.

8 July 2018

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High-efficiency gene transfer into normal and adenosine deaminase-deficient T lymphocytes is mediated by transduction on recombinant fibronectin fragments

8 July 2018

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P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

8 July 2018

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8 July 2018

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CYP4B1 activates 4-ipomeanol in rat lung

21 January 2018

1 reference

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4-Ipomeanol: a novel investigational new drug for lung cancer

8 July 2018

1 reference

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Metabolic activation of 4-ipomeanol by complementary DNA-expressed human cytochromes P-450: evidence for species-specific metabolism

8 July 2018

1 reference

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Role of metabolic activation in the pathogenesis of chemically induced pulmonary disease: mechanism of action of the lung-toxic furan, 4-ipomeanol

8 July 2018

1 reference

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Effects of 4-ipomeanol, a product from mold-damaged sweet potatoes, on the bovine lung

8 July 2018

1 reference

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Bioactivation of 4-ipomeanol by CYP4B1: adduct characterization and evidence for an enedial intermediate

8 July 2018

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Phase II study of 4-ipomeanol, a naturally occurring alkylating furan, in patients with advanced hepatocellular carcinoma

21 January 2018

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Genotyping and site-directed mutagenesis of a cytochrome P450 meander Pro-X-Arg motif critical to CYP4B1 catalysis

21 January 2018

1 reference

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Identification of a meander region proline residue critical for heme binding to cytochrome P450: implications for the catalytic function of human CYP4B1.

21 January 2018

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A transgenic mouse expressing human CYP4B1 in the liver

21 January 2018

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Colocalization of retrovirus and target cells on specific fibronectin fragments increases genetic transduction of mammalian cells

21 January 2018

1 reference

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Structure and function of cytochromes P450: a comparative analysis of three crystal structures.

21 January 2018

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The residue E351 is essential for the activity of human 21-hydroxylase: evidence from a naturally occurring novel point mutation compared with artificial mutants generated by single amino acid substitutions

21 January 2018

1 reference

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Identification of key residues in rabbit liver microsomal cytochrome P450 2B4: importance in interactions with NADPH-cytochrome P450 reductase.

21 January 2018

1 reference

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Differential cytotoxicity and bystander effect of the rabbit cytochrome P450 4B1 enzyme gene by two different prodrugs: implications for pharmacogene therapy

21 January 2018

1 reference

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A chimeric fusion protein of cytochrome CYP4B1 and green fluorescent protein for detection of pro-drug activating gene delivery and for gene therapy in malignant glioma

21 January 2018

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Toxicity of Mould-damaged Sweet Potatoes (Ipomoea batatas)

25 October 2018

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A Lung Oedema Factor from Mouldy Sweet Potatoes (Ipomoea batatas)

21 January 2018

1 reference

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Optimization of fibronectin-assisted retroviral gene transfer into human CD34+ hematopoietic cells

21 January 2018

1 reference

12 December 2020

TWO FATAL CASES OF POTATO POISONING

1 reference

12 December 2020

Metabolic activation and cytotoxicity of 4-ipomeanol in human non-small cell lung cancer lines

1 reference

12 December 2020

CYP4 isozyme specificity and the relationship between omega-hydroxylation and terminal desaturation of valproic acid

1 reference

12 December 2020

Phase I and pharmacological study of the pulmonary cytotoxin 4-ipomeanol on a single dose schedule in lung cancer patients: hepatotoxicity is dose limiting in humans

1 reference

12 December 2020

A close family resemblance: the importance of structure in understanding cytochromes P450

1 reference

12 December 2020

Phase I study of a five-day dose schedule of 4-Ipomeanol in patients with non-small cell lung cancer

1 reference

12 December 2020

Identifiers

DOI

10.1042/BJ20140813

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25247810%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25247810%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

1 reference