(Q35038994)

5 August 2017

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title

Use of the spontaneous Tsc2 knockout (Eker) rat model of hereditary renal cell carcinoma for the study of renal carcinogens (English)

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hereditary renal cell carcinoma

5 August 2017

main subject

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Kevin S McDorman

1

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5 August 2017

Douglas C Wolf

series ordinal

2

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5 August 2017

language of work or name

English

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publication date

1 November 2002

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5 August 2017

published in

Toxicologic Pathology

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5 August 2017

volume

30

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5 August 2017

issue

6

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5 August 2017

page(s)

675-680

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Chemicals associated with site-specific neoplasia in 1394 long-term carcinogenesis experiments in laboratory rodents

5 August 2017

cites work

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21 January 2018

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Development of high-grade renal cell carcinomas in rats independently of somatic mutations in the Tsc2 and VHL tumor suppressor genes.

21 January 2018

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TSC2 gene mutant (Eker) rat model of a Mendelian dominantly inherited cancer

21 January 2018

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Cloning of the rat homologue of the von Hippel-Lindau tumor suppressor gene and its non-somatic mutation in rat renal cell carcinomas

21 January 2018

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Renal cell carcinoma development in the rat independent of alterations at the VHL gene locus

21 January 2018

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von Hippel-Lindau gene mutations in N-nitrosodimethylamine-induced rat renal epithelial tumors.

21 January 2018

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Spontaneous and radiation-induced renal tumors in the Eker rat model of dominantly inherited cancer

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Loss of function of the tuberous sclerosis 2 tumor suppressor gene results in embryonic lethality characterized by disrupted neuroepithelial growth and development

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21 January 2018

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p53 status in spontaneous and dimethylnitrosamine-induced renal cell tumors from rats

21 January 2018

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Susceptibility to renal carcinoma in the Eker rat involves a tumor suppressor gene on chromosome 10

21 January 2018

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21 January 2018

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Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene

21 January 2018

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21 January 2018

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21 January 2018

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Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2

21 January 2018

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The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis

21 January 2018

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Identification of tuberin, the tuberous sclerosis-2 product. Tuberin possesses specific Rap1GAP activity

21 January 2018

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Malignant tumors of the kidney, brain, and soft tissues in children and young adults with the tuberous sclerosis complex.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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A Dominant Gene for Renal Adenomas in the Rat

21 January 2018

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10.1080/01926230290168542

21 January 2018

Identifiers

DOI

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5 August 2017

1 reference