(Q35041052)

6 August 2017

title

The effects of phosphodiesterase type 4 inhibitors on tumour necrosis factor-alpha and leukotriene B4 in a novel human whole blood assay (English)

1 reference

6 August 2017

0 references

1 reference

C Brideau

1

1 reference

6 August 2017

C Van Staden

2

1 reference

6 August 2017

A Styhler

3

1 reference

6 August 2017

I W Rodger

4

1 reference

6 August 2017

C C Chan

5

1 reference

6 August 2017

language of work or name

English

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publication date

1 February 1999

1 reference

British Journal of Pharmacology

6 August 2017

published in

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6 August 2017

volume

126

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6 August 2017

issue

4

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6 August 2017

page(s)

979-988

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1,4-Cyclohexanecarboxylates: potent and selective inhibitors of phosophodiesterase 4 for the treatment of asthma

6 August 2017

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Characterization of the prostanoid receptor(s) on human blood monocytes at which prostaglandin E2 inhibits lipopolysaccharide-induced tumour necrosis factor-alpha generation

8 July 2018

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8 July 2018

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8 July 2018

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Evidence that cyclic AMP phosphodiesterase inhibitors suppress TNF alpha generation from human monocytes by interacting with a 'low-affinity' phosphodiesterase 4 conformer

8 July 2018

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8 July 2018

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IL-1 and tumor necrosis factor-alpha each up-regulate both the expression of IFN-gamma receptors and enhance IFN-gamma-induced HLA-DR expression on human monocytes and a human monocytic cell line (THP-1).

8 July 2018

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The 55-kD tumor necrosis factor receptor on human keratinocytes is regulated by tumor necrosis factor-alpha and by ultraviolet B radiation

8 July 2018

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Tumor necrosis factor alpha (TNF-alpha)-induced cell adhesion to human endothelial cells is under dominant control of one TNF receptor type, TNF-R55.

8 July 2018

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8 July 2018

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Lipopolysaccharides prime whole human blood and isolated neutrophils for the increased synthesis of 5-lipoxygenase products by enhancing arachidonic acid availability: involvement of the CD14 antigen

8 July 2018

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Suppression of eosinophil function by RP 73401, a potent and selective inhibitor of cyclic AMP-specific phosphodiesterase: comparison with rolipram

8 July 2018

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Characterization of the PGE receptor subtype mediating inhibition of superoxide production in human neutrophils

8 July 2018

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PDE isoenzymes as targets for anti-asthma drugs

8 July 2018

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Leukotriene B4, a mediator of inflammation present in synovial fluid in rheumatoid arthritis

8 July 2018

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Shock and tissue injury induced by recombinant human cachectin

8 July 2018

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8 July 2018

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8 July 2018

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The biology of cachectin/TNF--a primary mediator of the host response

8 July 2018

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Bacterial lipopolysaccharides prime human neutrophils for enhanced production of leukotriene B4.

8 July 2018

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Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway

8 July 2018

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Effects of lipopolysaccharide on phospholipase A2 activity and tumor necrosis factor expression in HL-60 cells.

8 July 2018

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Leukotriene B4 in inflammation.

8 July 2018

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Antitumor activity of TNF-alpha, IL-1, and IFN-gamma against three human osteosarcoma cell lines.

8 July 2018

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Phosphodiesterase inhibitors: new opportunities for the treatment of asthma

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571215

Release of both preformed and newly synthesized tumor necrosis factor alpha (TNF-alpha)/cachectin by mouse mast cells stimulated via the Fc epsilon RI. A mechanism for the sustained action of mast cell-derived TNF-alpha during IgE-dependent biologic

8 July 2018

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Endogenous tumor necrosis factor, interleukin-6, and gamma interferon levels during Listeria monocytogenes infection in mice

8 July 2018

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Influence of selective phosphodiesterase inhibitors on human neutrophil functions and levels of cAMP and Cai.

8 July 2018

1 reference

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Stimulation of beta adrenoceptors in a human monocyte cell line (U937) up-regulates cyclic AMP-specific phosphodiesterase activity.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571215

Arachidonic acid metabolism in polymorphonuclear leukocytes: effects of ionophore A23187

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571215

Adenosine A2 receptor-induced inhibition of leukotriene B4 synthesis in whole blood ex vivo

8 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.BJP.0702387

Inhibition of phosphodiesterase IV and intracellular calcium levels in human polymorphonuclear leukocytes

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571215

Elevated cyclic AMP inhibits NF-kappaB-mediated transcription in human monocytic cells and endothelial cells.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571215

Effect of human cytokines (IFN-gamma, TNF-alpha, IL-1 beta, IL-4) on porcine endothelial cells: induction of MHC and adhesion molecules and functional significance of these changes

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571215

The Release of Leukotriene B4-like Material in Biologically Active Amounts from the Lesional Skin of patients with Psoriasis

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571215

The effects of antiinflammatory and antiallergic drugs on cytokine release after stimulation of human whole blood by lipopolysaccharide and zymosan A

25 October 2018

1 reference

12 December 2020

A novel phosphodiesterase inhibitor, T-440: possible management of eosinophilic inflammation by down-regulation of interleukin-5 production

1 reference

12 December 2020

A human whole blood assay for clinical evaluation of biochemical efficacy of cyclooxygenase inhibitors

1 reference

12 December 2020

Endogenous adenosine curtails lipopolysaccharide-stimulated tumour necrosis factor synthesis

1 reference

12 December 2020

Differential regulation of human antigen-specific Th1 and Th2 lymphocyte responses by isozyme selective cyclic nucleotide phosphodiesterase inhibitors

1 reference

12 December 2020

Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-alpha: role of the p38 and p42/44 mitogen-activated protein kinases

1 reference

12 December 2020

Enhanced synthesis of leukotriene B4 by colonic mucosa in inflammatory bowel disease

1 reference

12 December 2020

Identification of Chemotactic Lipoxygenase Products of Arachidonate Metabolism in Psoriatic Skin

1 reference

12 December 2020

Immunoregulatory activity of recombinant human tumor necrosis factor (TNF)-alpha: induction of TNF receptors on human T cells and TNF-alpha-mediated enhancement of T cell responses

1 reference

12 December 2020

Effects of selective phosphodiesterase inhibitors on the polymorphonuclear leukocyte respiratory burst

1 reference

12 December 2020

Cytokine-induced expression of transforming growth factor-alpha and the epidermal growth factor receptor in neonatal skin explants

1 reference

12 December 2020

The specific type III and IV phosphodiesterase inhibitor zardaverine suppresses formation of tumor necrosis factor by macrophages

1 reference

12 December 2020

Influence of isoproterenol and phosphodiesterase inhibitors on platelet-activating factor biosynthesis in the human neutrophil

1 reference

12 December 2020

The effects of anti-inflammatory and antiallergic drugs on the release of IL-1 beta and TNF-alpha in the human whole blood assay

1 reference

12 December 2020

Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs

1 reference

12 December 2020

Biochemical and pharmacological characterization of the cyclooxygenase activity of human blood prostaglandin endoperoxide synthases

1 reference

12 December 2020

Proinflammatory cytokines regulate cyclooxygenase-2 mRNA expression in human macrophages

1 reference

12 December 2020

Suppression of lipopolysaccharide-induced tumor necrosis factor-alpha generation from human peripheral blood monocytes by inhibitors of phosphodiesterase 4: interaction with stimulants of adenylyl cyclase

1 reference

12 December 2020

Prolonged beta adrenoceptor stimulation up-regulates cAMP phosphodiesterase activity in human monocytes by increasing mRNA and protein for phosphodiesterases 4A and 4B

1 reference

12 December 2020

Identifiers

DOI

10.1038/SJ.BJP.0702387

1 reference

6 August 2017

1 reference

6 August 2017

1 reference