(Q35047028)

6 August 2017

title

Cerebral uptake of mefloquine enantiomers with and without the P-gp inhibitor elacridar (GF1210918) in mice (English)

1 reference

6 August 2017

1 reference

1 reference

Sylvie Barraud de Lagerie

1

1 reference

6 August 2017

Emmanuelle Comets

2

1 reference

6 August 2017

Céline Gautrand

3

1 reference

6 August 2017

Christine Fernandez

4

1 reference

6 August 2017

Daniel Auchere

5

1 reference

6 August 2017

Eric Singlas

6

1 reference

6 August 2017

France Mentre

7

1 reference

6 August 2017

François Gimenez

8

1 reference

6 August 2017

language of work or name

English

0 references

publication date

15 March 2004

1 reference

British Journal of Pharmacology

6 August 2017

published in

1 reference

6 August 2017

volume

141

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6 August 2017

issue

7

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6 August 2017

page(s)

1214-1222

1 reference

Stereoselective and concentration-dependent polarized epithelial permeability of a series of phosphoramidate triester prodrugs of d4T: an in vitro study in Caco-2 and Madin-Darby canine kidney cell monolayers.

6 August 2017

cites work

1 reference

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Drug efflux transporters in the CNS.

8 July 2018

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Localisation of breast cancer resistance protein in microvessel endothelium of human brain

8 July 2018

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The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria.

8 July 2018

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Population pharmacokinetic and pharmacodynamic modelling of artemisinin and mefloquine enantiomers in patients with falciparum malaria

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574889

Stereoselective transport of hydrophilic quaternary drugs by human MDR1 and rat Mdr1b P-glycoproteins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574889

From MDR to MXR: new understanding of multidrug resistance systems, their properties and clinical significance.

8 July 2018

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Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574889

Interactions of racemic mefloquine and its enantiomers with P-glycoprotein in an immortalised rat brain capillary endothelial cell line, GPNT.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574889

Inhibitory effect of the reversal agents V-104, GF120918 and Pluronic L61 on MDR1 Pgp-, MRP1- and MRP2-mediated transport

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574889

Substrate-stereoselectivity of a high-affinity glutamate transporter cloned from the CNS of the cockroach Diploptera punctata

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574889

Cerebral uptake of mefloquine enantiomers in fatal cerebral malaria.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574889

Stereoselective passage of mefloquine through the blood-brain barrier in the rat.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574889

Enantioselective pharmacokinetics of mefloquine during long-term intake of the prophylactic dose

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574889

Stereoselective pharmacokinetics of mefloquine in healthy Caucasians after multiple doses

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574889

Critical issues in chiral drug analysis in biological fluids by high-performance liquid chromatography

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574889

Modulation of the function of human MDR1 P-glycoprotein by the antimalarial drug mefloquine.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574889

Stereoselective pharmacokinetics of mefloquine in young children

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574889

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574889

CNS adverse events associated with antimalarial agents. Fact or fiction?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574889

Neuropsychiatric side effects after the use of mefloquine

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574889

In vitro activity of the enantiomers of mefloquine, halofantrine and enpiroline against Plasmodium falciparum

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574889

Studies of the disposition and metabolism of mefloquine HCl (WR 142,490), a quinolinemethanol antimalarial, in the rat. Limited studies with an analog, WR 30,090

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574889

Effect of efflux inhibition on brain uptake of itraconazole in mice infected with Cryptococcus neoformans.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574889

Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574889

The enantioselective binding of mefloquine enantiomers to P-glycoprotein determined using an immobilized P-glycoprotein liquid chromatographic stationary phase.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574889

The absence of stereoselective P-glycoprotein- and multidrug resistance-associated protein-mediated transport of daunorubicin.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574889

Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574889

Transport mechanisms for the antidepressant citalopram in brain microvessel endothelium

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574889

The role of stereoselectivity of chemosensitizers in the reversal of multidrug resistance of mouse lymphoma cells.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574889

Uptake of mefloquine enantiomers into uninfected and malaria-infected erythrocytes.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1574889

The absence of stereoselective P-glycoprotein-mediated transport of R/S-verapamil across the rat jejunum

25 October 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.BJP.0705721

Mutually co-operative interactions between modulators of P-glycoprotein

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.BJP.0705721

Disposition of the diastereoisomer of mefloquine in mice

21 January 2018

1 reference

12 December 2020

Metabolic chiral inversion of stiripentol in the rat. II. Influence of route of administration

1 reference

12 December 2020

Whole blood concentrations of mefloquine enantiomers in healthy Thai volunteers

1 reference

12 December 2020

Kinetic parameters for reversal of the multidrug pump as measured for drug accumulation and cell killing

1 reference

12 December 2020

Identifiers

DOI

10.1038/SJ.BJP.0705721

1 reference

6 August 2017

1 reference

6 August 2017

1 reference