(Q35047180)

6 August 2017

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title

Lipoapoptosis: its mechanism and its diseases (English)

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6 August 2017

Roger H Unger

1

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6 August 2017

Lelio Orci

series ordinal

2

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6 August 2017

language of work or name

English

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publication date

1 December 2002

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Biochimica et Biophysica Acta

6 August 2017

published in

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6 August 2017

volume

1585

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6 August 2017

issue

2-3

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6 August 2017

page(s)

202-212

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Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover

6 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Apoptosis in cardiac diseases: stress- and mitogen-activated signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

The biochemistry of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

MAP kinase pathways activated by stress: the p38 MAPK pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Lipotoxic heart disease in obese rats: implications for human obesity

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Troglitazone lowers islet fat and restores beta cell function of Zucker diabetic fatty rats

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Biochemical pathways of caspase activation during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Identification of caspases and apoptosis in the simple metazoan Hydra

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Human ICE/CED-3 protease nomenclature

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Caspases: enemies within

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Double identity for proteins of the Bcl-2 family

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

A novel mouse model of lipotoxic cardiomyopathy

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Human and murine serine-palmitoyl-CoA transferase--cloning, expression and characterization of the key enzyme in sphingolipid synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Insulin prevents cardiomyocytes from oxidative stress-induced apoptosis through activation of PI3 kinase/Akt

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Akt mediates insulin rescue from apoptosis in brown adipocytes: effect of ceramide

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

BAD Enables Ceramide to Signal Apoptosis via Ras and Raf-1

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Ceramide Interaction with the Respiratory Chain of Heart Mitochondria†

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Mechanisms and consequences of activation of protein kinase B/Akt

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

The "thrifty genotype" in 1998

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Life without white fat: a transgenic mouse

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Troglitazone action is independent of adipose tissue

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Leptin-replacement therapy for lipodystrophy.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

OB-Rb gene transfer to leptin-resistant islets reverses diabetogenic phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Liporegulation in diet-induced obesity. The antisteatotic role of hyperleptinemia

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

AdipoQ is a novel adipose-specific gene dysregulated in obesity

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Adipose tissue as an endocrine organ

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Regulation of fatty acid homeostasis in cells: novel role of leptin

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Leptin physiology: a second look

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Weight-reducing effects of the plasma protein encoded by the obese gene

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Abnormal splicing of the leptin receptor in diabetic mice

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Substitution at codon 269 (glutamine --> proline) of the leptin receptor (OB-R) cDNA is the only mutation found in the Zucker fatty (fa/fa) rat.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Direct antidiabetic effect of leptin through triglyceride depletion of tissues.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Peroxisome proliferator-activated receptors and lipid metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Reversing adipocyte differentiation: implications for treatment of obesity

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Enhanced de novo lipogenesis in the leptin-unresponsive pancreatic islets of prediabetic Zucker diabetic fatty rats: role in the pathogenesis of lipotoxic diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Increased lipogenic capacity of the islets of obese rats: a role in the pathogenesis of NIDDM.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Diseases of liporegulation: new perspective on obesity and related disorders

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Leptin- or troglitazone-induced lipopenia protects islets from interleukin 1beta cytotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Palmitate-induced apoptosis can occur through a ceramide-independent pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Essential fatty acids, lipid peroxidation and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Glucose and palmitic acid induce degeneration of myofibrils and modulate apoptosis in rat adult cardiomyocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

Congenital leptin deficiency is associated with severe early-onset obesity in humans

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

The role of leptin resistance in the lipid abnormalities of aging.

1 reference

https://api.crossref.org/works/10.1016%2FS1388-1981%2802%2900342-6

7 January 2021

10.1016/S1388-1981(02)00342-6

Identifiers

DOI

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6 August 2017

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