(Q35048897)

6 August 2017

title

PLK1 inhibition down-regulates polycomb group protein BMI1 via modulation of the miR-200c/141 cluster (English)

1 reference

6 August 2017

Manjari Dimri

1

1 reference

6 August 2017

Joon-Ho Cho

series ordinal

2

1 reference

6 August 2017

Mingu Kang

series ordinal

3

1 reference

6 August 2017

Goberdhan P Dimri

series ordinal

4

1 reference

6 August 2017

language of work or name

English

0 references

publication date

12 December 2014

1 reference

Journal of Biological Chemistry

6 August 2017

published in

1 reference

6 August 2017

volume

290

1 reference

6 August 2017

issue

5

1 reference

6 August 2017

page(s)

3033-3044

1 reference

describes a project that uses

6 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4317019/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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microRNA-141 regulates BMI1 expression and induces senescence in human diploid fibroblasts

8 July 2018

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In vivo RNAi screen for BMI1 targets identifies TGF-β/BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis.

8 July 2018

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MicroRNA-218 inhibits cell cycle progression and promotes apoptosis in colon cancer by downregulating BMI1 polycomb ring finger oncogene

8 July 2018

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A positive feedback loop regulates the expression of polycomb group protein BMI1 via WNT signaling pathway

8 July 2018

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8 July 2018

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8 July 2018

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βTrCP regulates BMI1 protein turnover via ubiquitination and degradation.

8 July 2018

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8 July 2018

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Bmi-1 is a crucial regulator of prostate stem cell self-renewal and malignant transformation

8 July 2018

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8 July 2018

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Role of DNA methylation in miR-200c/141 cluster silencing in invasive breast cancer cells

8 July 2018

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Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy

8 July 2018

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The polycomb group protein BMI1 is a transcriptional target of HDAC inhibitors.

8 July 2018

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MiR-15a and MiR-16 control Bmi-1 expression in ovarian cancer

8 July 2018

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Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells

8 July 2018

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Bmi1 is expressed in vivo in intestinal stem cells

8 July 2018

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8 July 2018

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The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2

8 July 2018

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The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

8 July 2018

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Bmi-1 cooperates with H-Ras to transform human mammary epithelial cells via dysregulation of multiple growth-regulatory pathways.

8 July 2018

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The biology of cancer stem cells

8 July 2018

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Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells

8 July 2018

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Modeling breast cancer-associated c-Src and EGFR overexpression in human MECs: c-Src and EGFR cooperatively promote aberrant three-dimensional acinar structure and invasive behavior

8 July 2018

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BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo.

8 July 2018

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Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins

8 July 2018

1 reference

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Polycomb silencers control cell fate, development and cancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317019

BMI1 is a target gene of E2F-1 and is strongly expressed in primary neuroblastomas

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317019

Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways

8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317019

What has senescence got to do with cancer?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317019

Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317019

The search for biomarkers of aging: next stop INK4a/ARF locus

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317019

Overexpression of Bmi-1 oncoprotein correlates with axillary lymph node metastases in invasive ductal breast cancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317019

Stem cells and cancer; the polycomb connection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317019

Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317019

Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317019

Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317019

The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317019

Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317019

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317019

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4317019

Bmi-1 extends the life span of normal human oral keratinocytes by inhibiting the TGF-beta signaling

8 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.615179

Targeting polo-like kinase 1 for cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.615179

Downregulation of Polo-like kinase 1 induces cellular senescence in human primary cells through a p53-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.615179

The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.615179

21 January 2018

Identifiers

DOI

10.1074/JBC.M114.615179

1 reference

6 August 2017

1 reference

6 August 2017

1 reference