(Q35049306)

6 August 2017

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title

Pharmacokinetics and pharmacodynamics of methotrexate in non-neoplastic diseases (English)

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6 August 2017

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Jirí Grim

1

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6 August 2017

Jaroslav Chládek

series ordinal

2

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6 August 2017

Jirina Martínková

series ordinal

3

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6 August 2017

publication date

1 January 2003

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Clinical Pharmacokinetics

6 August 2017

published in

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6 August 2017

volume

42

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6 August 2017

issue

2

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6 August 2017

page(s)

139-151

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Supplementation with folic acid during methotrexate therapy for rheumatoid arthritis. A double-blind, placebo-controlled trial

6 August 2017

cites work

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12 December 2020

Pharmacokinetics of low doses of methotrexate in patients with psoriasis over the early period of treatment

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12 December 2020

Clinical pharmacology of methotrexate

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12 December 2020

Methotrexate metabolism analysis in blood and liver of rheumatoid arthritis patients. Association with hepatic folate deficiency and formation of polyglutamates

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12 December 2020

Methotrexate in rheumatoid arthritis. Health and Public Policy Committee, American College of Physicians

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12 December 2020

Pharmacokinetics of low-dose methotrexate in rheumatoid arthritis patients

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12 December 2020

Methotrexate in rheumatoid arthritis. A five-year prospective multicenter study

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12 December 2020

The pharmacology of methotrexate

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12 December 2020

Aminophylline for methotrexate-induced neurotoxicity

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12 December 2020

The efficacy of folic acid and folinic acid in reducing methotrexate gastrointestinal toxicity in rheumatoid arthritis. A metaanalysis of randomized controlled trials.

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12 December 2020

Effect of etodolac on methotrexate pharmacokinetics in patients with rheumatoid arthritis

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12 December 2020

Pharmacokinetics and pharmacodynamics of low-dose methotrexate in the treatment of psoriasis

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12 December 2020

The metabolic fate of tritiated methotrexate. II. Absorption and excretion in man

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12 December 2020

Liver biopsies from psoriatics related to methotrexate therapy. 3. Findings in post-methotrexate liver biopsies from 160 psoriatics

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12 December 2020

Topical treatment of psoriatic skin with methotrexate cream: a clinical, pharmacokinetic, and histological study

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12 December 2020

Methotrexate reduces inflammatory cell numbers, expression of monokines and of adhesion molecules in synovial tissue of patients with rheumatoid arthritis

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12 December 2020

Clinical pharmacokinetics of low-dose pulse methotrexate in rheumatoid arthritis

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12 December 2020

Methotrexate hepatotoxicity in psoriasis. Consideration of liver biopsies at regular intervals

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12 December 2020

The effects of daily intake of folic acid on the efficacy of methotrexate therapy in children with juvenile rheumatoid arthritis. A controlled study

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12 December 2020

[Blood cell concentration of methotrexate in long-term therapy of inflammatory rheumatic diseases]

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12 December 2020

Plasma levels after oral methotrexate in children with juvenile rheumatoid arthritis

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12 December 2020

Methotrexate treatment of rheumatoid arthritis: is a fortnightly maintenance schedule enough?

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12 December 2020

Methotrexate toxicity in a patient receiving trimethoprim-sulfamethoxazole

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12 December 2020

Low-dose methotrexate compared with auranofin in adult rheumatoid arthritis. A thirty-six-week, double-blind trial

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12 December 2020

Homocysteine levels in patients with rheumatoid arthritis treated with low-dose methotrexate

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12 December 2020

Methotrexate revisited: effects of long-term treatment in psoriasis

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12 December 2020

Low dose leucovorin does not interfere with the efficacy of methotrexate in rheumatoid arthritis: an 8 week randomized placebo controlled trial

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12 December 2020

Methotrexate in psoriatic polyarthritis

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12 December 2020

The population pharmacokinetics of long-term methotrexate in rheumatoid arthritis

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12 December 2020

Practical clinical pharmacology and drug interactions of low-dose methotrexate therapy in rheumatoid arthritis.

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12 December 2020

Methotrexate induces clinical and histologic remission in patients with refractory inflammatory bowel disease

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12 December 2020

Methotrexate pharmacokinetics after intraarticular injection in patients with rheumatoid arthritis

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12 December 2020

The pharmacokinetics of methotrexate and its 7-hydroxy metabolite in patients with rheumatoid arthritis

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12 December 2020

The mechanism of action of methotrexate

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12 December 2020

Long-term prospective study of methotrexate in the treatment of rheumatoid arthritis. 84-month update

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12 December 2020

Drug-drug interactions with antirheumatic agents: review of selected clinically important interactions

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12 December 2020

Lack of significant interaction between low dose methotrexate and ibuprofen or flurbiprofen in patients with arthritis

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12 December 2020

The rational use of methotrexate in rheumatoid arthritis and other rheumatic diseases

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12 December 2020

Pharmacokinetics and renal function in patients with rheumatoid arthritis receiving a standard dose of oral weekly methotrexate: association with significant decreases in creatinine clearance and renal clearance of the drug after 6 months of therapy

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12 December 2020

The incidence of cancer associated with the treatment of rheumatoid arthritis

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12 December 2020

Bone mass change during methotrexate treatment in patients with juvenile rheumatoid arthritis

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12 December 2020

Risk factors for methotrexate-induced lung injury in patients with rheumatoid arthritis. A multicenter, case-control study. Methotrexate-Lung Study Group

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12 December 2020

Clinical Pharmacokinetics of Methotrexate1

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12 December 2020

Adenosine enhances IL-10 secretion by human monocytes

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12 December 2020

Methotrexate: anti-inflammatory or immunosuppressive?

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12 December 2020

Correlation between methotrexate pharmacokinetic parameters, and clinical and biological status in rheumatoid arthritis patients

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12 December 2020

Reduced folate carrier (RFC-1) gene expression in normal and psoriatic skin

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12 December 2020

Pancytopenia and methotrexate with trimethoprim-sulfamethoxazole

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12 December 2020

Folic acid alters methotrexate availability in patients with rheumatoid arthritis

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12 December 2020

Pharmacokinetics of methotrexate in erythrocytes in psoriasis

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12 December 2020

Adverse experience with methotrexate during 176 weeks of a longterm prospective trial in patients with rheumatoid arthritis.

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12 December 2020

Therapeutic use of theophylline to antagonize renal effects of adenosine.

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12 December 2020

Methotrexate induced liver cirrhosis. Studies including serial liver biopsies during continued treatment

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12 December 2020

Are there differences in methotrexate kinetics between responding and nonresponding patients with rheumatoid arthritis?

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12 December 2020

Influence of sulphasalazine, methotrexate, and the combination of both on plasma homocysteine concentrations in patients with rheumatoid arthritis

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12 December 2020

Impact of methotrexate therapy on the folate status of psoriatic patients

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12 December 2020

Serum type III procollagen peptide, dynamic liver function tests and hepatic fibrosis in psoriatic patients receiving methotrexate

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12 December 2020

Effect of food on the bioavailability of low-dose methotrexate in patients with rheumatoid arthritis

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12 December 2020

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12 December 2020

A practical approach to avoidance of methotrexate toxicity

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12 December 2020

Folic acid supplementation prevents deficient blood folate levels and hyperhomocysteinemia during longterm, low dose methotrexate therapy for rheumatoid arthritis: implications for cardiovascular disease prevention.

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12 December 2020

Methotrexate disposition following concomitant administration of ketoprofen, piroxicam and flurbiprofen in patients with rheumatoid arthritis

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12 December 2020

Adenosine inhibits cytokine release and expression of adhesion molecules by activated human endothelial cells

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12 December 2020

Methotrexate--the rapidly acting drug

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12 December 2020

Liver biopsy in methotrexate-treated psoriatics-a re-evalution

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12 December 2020

Methotrexate in chronic active Crohn's disease: a double-blind, randomized, Israeli multicenter trial

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12 December 2020

Homocysteine and folate status in methotrexate-treated patients with rheumatoid arthritis

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12 December 2020

The use of folates concomitantly with low-dose pulse methotrexate

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12 December 2020

Increasing methotrexate effect with increasing dose in the treatment of resistant rheumatoid arthritis.

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12 December 2020

Methotrexate in patients with Crohn's disease after 6-mercaptopurine

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12 December 2020

Methotrexate hepatotoxicity in psoriatic patients submitted to long-term therapy

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12 December 2020

Methotrexate treatment for sarcoid-associated panuveitis

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12 December 2020

A trial of etanercept, a recombinant tumor necrosis factor receptor:Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate

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12 December 2020

Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5'-nucleotidase-mediated conversion of adenine nucleotides

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12 December 2020

An overview of the treatment of childhood SLE.

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12 December 2020

Pancytopenia associated with low dose methotrexate therapy. A regional survey

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12 December 2020

Intraindividual variability of the bioavailability of low dose methotrexate after oral administration in rheumatoid arthritis

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12 December 2020

The effect of folic acid supplementation on the toxicity of low-dose methotrexate in patients with rheumatoid arthritis

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12 December 2020

Methotrexate in rheumatoid arthritis: an update with focus on mechanisms involved in toxicity

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12 December 2020

Management of cutaneous lupus erythematosus with low-dose methotrexate: indication for modulation of inflammatory mechanisms

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12 December 2020

Study of eight cases of cancer in 426 rheumatoid arthritis patients treated with methotrexate

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12 December 2020

A comparison of low dose methotrexate bioavailability: oral solution, oral tablet, subcutaneous and intramuscular dosing

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12 December 2020

Methotrexate in rheumatoid arthritis. An update

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12 December 2020

Inhibition of TNF-alpha expression by adenosine: role of A3 adenosine receptors

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12 December 2020

Low-dose methotrexate with leucovorin (folinic acid) in the management of rheumatoid arthritis. Results of a multicenter randomized, double-blind, placebo-controlled trial

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12 December 2020

Total and free methotrexate pharmacokinetics in rheumatoid arthritis patients.

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12 December 2020

Total and free methotrexate pharmacokinetics, with and without piroxicam, in rheumatoid arthritis patients.

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12 December 2020

Pharmacokinetics of methotrexate administered by intramuscular and subcutaneous injections in patients with rheumatoid arthritis

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12 December 2020

Methotrexate maintenance therapy and liver damage in psoriasis

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12 December 2020

Methotrexate kinetics in rheumatoid arthritis: is there an interaction with nonsteroidal antiinflammatory drugs?

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12 December 2020

Methotrexate concentrations in synovial membrane and trabecular and cortical bone in rheumatoid arthritis patients

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12 December 2020

gamma-Glutamyl hydrolase and folylpolyglutamate synthetase activities predict polyglutamylation of methotrexate in acute leukemias

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12 December 2020

Nonlinear renal elimination kinetics of methotrexate due to saturation of renal tubular reabsorption

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12 December 2020

Methotrexate and trimethoprim-sulphamethoxazole--a potentially hazardous combination.

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12 December 2020

Toxicity and serum levels of methotrexate in children with juvenile rheumatoid arthritis

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12 December 2020

Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida

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12 December 2020

Severe pancytopenia in a patient taking low dose methotrexate and probenecid

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12 December 2020

Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cells

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12 December 2020

A limited sampling method to estimate methotrexate pharmacokinetics in patients with rheumatoid arthritis using a Bayesian approach and the population data modeling program P-PHARM.

1 reference

12 December 2020

Long-term prospective study of the use of methotrexate in the treatment of rheumatoid arthritis. Update after a mean of 90 months

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12 December 2020

Comparison of the sensitivity of normal hematopoietic and transplanted lymphoma colony-forming cells to chemotherapeutic agents administered in vivo

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12 December 2020

Methotrexate in rheumatoid arthritis--a limited sampling strategy for estimation of the area under the plasma concentration versus time curve.

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12 December 2020

Do steroids influence low dose methotrexate pharmacokinetics?

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12 December 2020

10.2165/00003088-200342020-00003

Identifiers

DOI

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Dimensions Publication ID

6 August 2017

1018988219

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