(Q35058996)

6 August 2017

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title

Epigenetic gene silencing in cancer initiation and progression (English)

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6 August 2017

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Kenneth P Nephew

1

1 reference

PubMed ID

12565166

6 August 2017

Tim Hui-Ming Huang

series ordinal

2

1 reference

PubMed ID

12565166

6 August 2017

language of work or name

English

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publication date

1 February 2003

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6 August 2017

1 reference

6 August 2017

190

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6 August 2017

125-133

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6 August 2017

2

1 reference

Amount and distribution of 5-methylcytosine in human DNA from different types of tissues of cells

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Number of CpG islands and genes in human and mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Initial sequencing and analysis of the human genome

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

The Sequence of the Human Genome

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

The fundamental role of epigenetic events in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

DNA methylation: past, present and future directions

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Methylation profiling of CpG islands in human breast cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Methylation-specific oligonucleotide microarray: a new potential for high-throughput methylation analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Methylation profiling in acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Oncogenes and tumor suppressor genes.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Cancer epigenetics comes of age

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Activation of the p53 DNA damage response pathway after inhibition of DNA methyltransferase by 5-aza-2'-deoxycytidine.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Suppression of intestinal neoplasia by DNA hypomethylation.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Altered methylation patterns in cancer cell genomes: cause or consequence?

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Confluence-induced alterations in CpG island methylation in cultured normal human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Increased cytosine DNA-methyltransferase activity during colon cancer progression

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Cloning, expression and chromosome locations of the human DNMT3 gene family

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Increased DNA methyltransferase expression in leukaemia

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

DNA methylation in ovarian cancer. II. Expression of DNA methyltransferases in ovarian cancer cell lines and normal ovarian epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Role of DNA 5-methylcytosine transferase in cell transformation by fos

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Differential mRNA expression of the human DNA methyltransferases (DNMTs) 1, 3a and 3b during the G(0)/G(1) to S phase transition in normal and tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Lsh, a member of the SNF2 family, is required for genome-wide methylation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Site specificity of the Arabidopsis METI DNA methyltransferase demonstrated through hypermethylation of the superman locus

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Requirement of CHROMOMETHYLASE3 for maintenance of CpXpG methylation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Growing Y-junction carbon nanotubes

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

DNMT1 and DNMT3b cooperate to silence genes in human cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

DNA methyltransferase Dnmt1 associates with histone deacetylase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

CpG methylation is maintained in human cancer cells lacking DNMT1.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

The impact of chromatin in human cancer: linking DNA methylation to gene silencing

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Translating the Histone Code

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Histone acetylation in chromatin structure and transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Histone methylation in transcriptional control

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

A histone H3 methyltransferase controls DNA methylation in Neurospora crassa

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

CpG island methylator phenotype in colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Concordant CpG island methylation in hyperplastic polyposis.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

p16 inactivation by methylation of the CDKN2A promoter occurs early during neoplastic progression in Barrett's esophagus

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Promoter methylation status of E-cadherin, hMLH1, and p16 genes in nonneoplastic gastric epithelia

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Hypermethylation of 14-3-3 sigma (stratifin) is an early event in breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Gene-Expression Profiles in Hereditary Breast Cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Gene expression profiling predicts clinical outcome of breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

DNA methylation patterns and epigenetic memory

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Methylation patterns of the E-cadherin 5' CpG island are unstable and reflect the dynamic, heterogeneous loss of E-cadherin expression during metastatic progression

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Methyl-CpG-binding proteins. Targeting specific gene repression.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Selective association of the methyl-CpG binding protein MBD2 with the silent p14/p16 locus in human neoplasia

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Altered chromatin structure associated with methylation-induced gene silencing in cancer cells: correlation of accessibility, methylation, MeCP2 binding and acetylation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Molecular mechanisms of gene silencing mediated by DNA methylation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Susceptibility of nonpromoter CpG islands to de novo methylation in normal and neoplastic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Cancer statistics, 2001

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

DNA methylation and ovarian cancer. I. Analysis of CpG island hypermethylation in human ovarian cancer using differential methylation hybridization.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

A role for methylation of the hMLH1 promoter in loss of hMLH1 expression and drug resistance in ovarian cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

DNA methylation as a target for drug design

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

Epigenomics and epigenetic therapy of cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900511-6

7 January 2021

10.1016/S0304-3835(02)00511-6

Identifiers

DOI

1 reference

6 August 2017

1 reference

PubMed ID

12565166