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Intrathecal PKA-selective siRNA treatment blocks sustained morphine-mediated pain sensitization and antinociceptive tolerance in rats
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1 reference
stated in
Europe PubMed Central
PMC publication ID
3120016
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21571003%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
title
Intrathecal PKA-selective siRNA treatment blocks sustained morphine-mediated pain sensitization and antinociceptive tolerance in rats
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
3120016
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21571003%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
author
Tally Largent-milnes
series ordinal
3
1 reference
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Europe PubMed Central
PMC publication ID
3120016
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21571003%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
author name string
S Tumati
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1
1 reference
stated in
Europe PubMed Central
PMC publication ID
3120016
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21571003%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
W R Roeske
series ordinal
2
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Europe PubMed Central
PMC publication ID
3120016
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21571003%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
T W Vanderah
series ordinal
4
1 reference
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PMC publication ID
3120016
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21571003%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
E V Varga
series ordinal
5
1 reference
stated in
Europe PubMed Central
PMC publication ID
3120016
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21571003%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
publication date
6 May 2011
1 reference
stated in
Europe PubMed Central
PMC publication ID
3120016
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21571003%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
published in
Journal of Neuroscience Methods
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stated in
Europe PubMed Central
PMC publication ID
3120016
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21571003%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
volume
199
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PMC publication ID
3120016
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21571003%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
issue
1
1 reference
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Europe PubMed Central
PMC publication ID
3120016
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21571003%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
page(s)
62-68
1 reference
stated in
Europe PubMed Central
PMC publication ID
3120016
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21571003%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
cites work
Sustained morphine-mediated pain sensitization and antinociceptive tolerance are blocked by intrathecal treatment with Raf-1-selective siRNA.
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PubMed Central
reference URL
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Sustained morphine treatment augments capsaicin-evoked calcitonin gene-related peptide release from primary sensory neurons in a protein kinase A- and Raf-1-dependent manner
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Intrathecal Raf-1-selective siRNA attenuates sustained morphine-mediated thermal hyperalgesia
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Pre-treatment with a PKC or PKA inhibitor prevents the development of morphine tolerance but not physical dependence in mice
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Sustained morphine treatment augments basal CGRP release from cultured primary sensory neurons in a Raf-1 dependent manner
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Inhibition of the cyclic adenosine monophosphate pathway attenuates neuropathic pain and reduces phosphorylation of cyclic adenosine monophosphate response element-binding in the spinal cord after partial sciatic nerve ligation in rats.
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Sustained morphine exposure induces a spinal dynorphin-dependent enhancement of excitatory transmitter release from primary afferent fibers.
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Morphine treatment induced calcitonin gene-related peptide and substance P increases in cultured dorsal root ganglion neurons
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based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.JNEUMETH.2011.04.036
1 reference
stated in
Europe PubMed Central
PMC publication ID
3120016
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21571003%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
PMC publication ID
3120016
1 reference
stated in
Europe PubMed Central
PMC publication ID
3120016
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21571003%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
PubMed publication ID
21571003
1 reference
stated in
Europe PubMed Central
PMC publication ID
3120016
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21571003%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
ResearchGate publication ID
51125561
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