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The soluble CTLA-4 splice variant protects from type 1 diabetes and potentiates regulatory T-cell function
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scholarly article
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Europe PubMed Central
PMC publication ID
3121435
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21602513%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
title
The soluble CTLA-4 splice variant protects from type 1 diabetes and potentiates regulatory T-cell function
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
3121435
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21602513%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
main subject
type-1 diabetes
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author
Peilin Zheng
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
3121435
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21602513%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
S Kissler
series ordinal
6
1 reference
stated in
Europe PubMed Central
PMC publication ID
3121435
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21602513%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
author name string
Kay D Gerold
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
3121435
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21602513%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
Daniel B Rainbow
series ordinal
3
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Europe PubMed Central
PMC publication ID
3121435
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21602513%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
Linda S Wicker
series ordinal
5
1 reference
stated in
Europe PubMed Central
PMC publication ID
3121435
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21602513%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
Alma Zernecke
series ordinal
4
1 reference
stated in
Europe PubMed Central
PMC publication ID
3121435
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21602513%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
language of work or name
English
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publication date
20 May 2011
1 reference
stated in
Europe PubMed Central
PMC publication ID
3121435
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21602513%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
published in
Diabetes
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stated in
Europe PubMed Central
PMC publication ID
3121435
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21602513%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
volume
60
1 reference
stated in
Europe PubMed Central
PMC publication ID
3121435
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21602513%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
issue
7
1 reference
stated in
Europe PubMed Central
PMC publication ID
3121435
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21602513%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
page(s)
1955-1963
1 reference
stated in
Europe PubMed Central
PMC publication ID
3121435
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21602513%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
copyright license
Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported
start time
27 August 2021
1 reference
stated in
April 2022 Public Data File from Crossref
copyright status
copyrighted
0 references
cites work
Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4
1 reference
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PubMed Central
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8 July 2018
CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms
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PubMed Central
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8 July 2018
Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice.
1 reference
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PubMed Central
reference URL
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8 July 2018
Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource
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PubMed Central
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8 July 2018
REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis
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PubMed Central
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8 July 2018
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
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PubMed Central
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8 July 2018
CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121435
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8 July 2018
Immunoregulatory pathways controlling progression of autoimmunity in NOD mice
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8 July 2018
Alternative isoform regulation in human tissue transcriptomes
1 reference
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PubMed Central
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8 July 2018
CTLA-4 control over Foxp3+ regulatory T cell function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121435
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8 July 2018
Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121435
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8 July 2018
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
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PubMed Central
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8 July 2018
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity
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PubMed Central
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8 July 2018
Reversal of the TCR stop signal by CTLA-4
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121435
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8 July 2018
A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells
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8 July 2018
The NOD mouse: a model of immune dysregulation
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PubMed Central
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8 July 2018
Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121435
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8 July 2018
An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121435
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8 July 2018
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
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PubMed Central
reference URL
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8 July 2018
Diversity of regulatory CD4+T cells controlling distinct organ-specific autoimmune diseases
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121435
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8 July 2018
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121435
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8 July 2018
Structure of murine CTLA-4 and its role in modulating T cell responsiveness
1 reference
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PubMed Central
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8 July 2018
Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.
1 reference
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PubMed Central
reference URL
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8 July 2018
Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121435
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8 July 2018
A native soluble form of CTLA-4
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121435
retrieved
8 July 2018
A soluble form of CTLA-4 generated by alternative splicing is expressed by nonstimulated human T cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121435
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8 July 2018
B7-1 engagement of cytotoxic T lymphocyte antigen 4 inhibits T cell activation in the absence of CD28.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121435
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8 July 2018
CTLA-4 ligation blocks CD28-dependent T cell activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121435
retrieved
8 July 2018
CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121435
retrieved
8 July 2018
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121435
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8 July 2018
Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121435
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8 July 2018
In vivo RNA interference demonstrates a role for Nramp1 in modifying susceptibility to type 1 diabetes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121435
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27 September 2018
Association of CTLA4 polymorphism with regulatory T cell frequency.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121435
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27 September 2018
Modulation of tryptophan catabolism by regulatory T cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121435
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27 September 2018
The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121435
retrieved
27 September 2018
Ctla-4 controls regulatory T cell peripheral homeostasis and is required for suppression of pancreatic islet autoimmunity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121435
retrieved
27 September 2018
Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121435
retrieved
27 September 2018
CD4+CD25+ regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21602513
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.2337/DB11-0130
1 reference
stated in
Europe PubMed Central
PMC publication ID
3121435
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21602513%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
PMC publication ID
3121435
1 reference
stated in
Europe PubMed Central
PMC publication ID
3121435
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21602513%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
PubMed publication ID
21602513
1 reference
stated in
Europe PubMed Central
PMC publication ID
3121435
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21602513%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
ResearchGate publication ID
51156111
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