(Q35064910)

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Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.).

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24328678%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.). (English)

1 reference

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3 March 2020

7

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3 March 2020

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Anita K Gandhi

1

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3 March 2020

Jian Kang

2

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3 March 2020

Courtney G Havens

3

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3 March 2020

Thomas Conklin

4

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3 March 2020

Yuhong Ning

5

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3 March 2020

Lei Wu

6

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3 March 2020

Hideki Ando

8

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3 March 2020

Michelle F Waldman

9

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3 March 2020

Anjan Thakurta

10

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3 March 2020

Anke Klippel

11

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3 March 2020

Hiroshi Handa

12

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3 March 2020

Thomas O Daniel

13

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3 March 2020

Peter H Schafer

14

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3 March 2020

Rajesh Chopra

15

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3 March 2020

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13 December 2013

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3 March 2020

British Journal of Haematology

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3 March 2020

164

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3 March 2020

6

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Europe PubMed Central

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3 March 2020

811-821

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3 March 2020

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1 reference

Europe PubMed Central

22 June 2022

https://europepmc.org/article/PMC/4232904

based on heuristic

inferred from PubMed Central ID database lookup

Immunomodulatory effects in a phase II study of lenalidomide combined with cetuximab in refractory KRAS-mutant metastatic colorectal cancer patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232904

8 July 2018

Aiolos promotes TH17 differentiation by directly silencing Il2 expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232904

8 July 2018

Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232904

8 July 2018

Systematic and quantitative assessment of the ubiquitin-modified proteome

1 reference

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8 July 2018

Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide.

1 reference

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8 July 2018

Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells

1 reference

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8 July 2018

Integrative genomic analyses on Ikaros and its expression related to solid cancer prognosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232904

8 July 2018

Ikaros and Aiolos inhibit pre-B-cell proliferation by directly suppressing c-Myc expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232904

8 July 2018

Identification of a primary target of thalidomide teratogenicity

1 reference

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8 July 2018

Differential aiolos expression in human hematopoietic subpopulations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232904

8 July 2018

The anti-cancer agents lenalidomide and pomalidomide inhibit the proliferation and function of T regulatory cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232904

8 July 2018

Expression of spliced oncogenic Ikaros isoforms in Philadelphia-positive acute lymphoblastic leukemia patients treated with tyrosine kinase inhibitors: implications for a new mechanism of resistance

1 reference

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Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232904

8 July 2018

Ikaros enforces the costimulatory requirement for IL2 gene expression and is required for anergy induction in CD4+ T lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232904

8 July 2018

Interleukin 2 gene transcription is regulated by Ikaros-induced changes in histone acetylation in anergic T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232904

8 July 2018

Linear models and empirical bayes methods for assessing differential expression in microarray experiments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232904

8 July 2018

Expression of aberrantly spliced oncogenic ikaros isoforms in childhood acute lymphoblastic leukemia

1 reference

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8 July 2018

Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232904

8 July 2018

Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232904

8 July 2018

Aiolos regulates B cell activation and maturation to effector state

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232904

8 July 2018

Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232904

8 July 2018

Genome-wide identification of Ikaros targets elucidates its contribution to mouse B-cell lineage specification and pre-B-cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232904

27 September 2018

lenalidomide enhances natural killer cell and monocyte-mediated antibody-dependent cellular cytotoxicity of rituximab-treated CD20+ tumor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232904

27 September 2018

Pharmacokinetics of lenalidomide in subjects with various degrees of renal impairment and in subjects on hemodialysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232904

27 September 2018

Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4232904

27 September 2018

Enhancement of cytokine production and AP-1 transcriptional activity in T cells by thalidomide-related immunomodulatory drugs

1 reference

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Protective antitumor immunity induced by a costimulatory thalidomide analog in conjunction with whole tumor cell vaccination is mediated by increased Th1-type immunity

1 reference

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27 September 2018

Helios deficiency has minimal impact on T cell development and function

1 reference

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The IKZF3 (Aiolos) transcription factor is highly upregulated and inversely correlated with clinical progression in chronic lymphocytic leukaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/24328678

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Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-alpha

1 reference

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based on heuristic

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Identifiers

10.1111/BJH.12708

1 reference

Europe PubMed Central

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3 March 2020

PMC publication ID

1 reference

Europe PubMed Central

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3 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24328678%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

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