(Q35071342)

6 August 2017

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title

Clinical potential of sodium-calcium exchanger inhibitors as antiarrhythmic agents (English)

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6 August 2017

Steven M Pogwizd

1

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6 August 2017

1 January 2003

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6 August 2017

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6 August 2017

63

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6 August 2017

5

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6 August 2017

439-452

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https://scigraph.springernature.com/pub.10.2165/00003495-200363050-00001

6 August 2017

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cites work

Inward sodium current at resting potentials in single cardiac myocytes induced by the ischemic metabolite lysophosphatidylcholine

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12 December 2020

Inhibition of sodium-calcium exchange in cardiac sarcolemmal membrane vesicles. 2. Mechanism of inhibition by bepridil

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12 December 2020

Contribution of reverse-mode sodium-calcium exchange to contractions in failing human left ventricular myocytes.

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12 December 2020

Possible mechanisms of ventricular arrhythmias elicited by ischemia followed by reperfusion. Studies on isolated canine ventricular tissues

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12 December 2020

Influence of a Na+-H+ exchange inhibitor ethylisopropylamiloride, a Na+-Ca2+ exchange inhibitor KB-R7943 and their combination on the increases in contractility and Ca2+ transient induced by angiotensin II in isolated adult rabbit ventricular myocyt

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12 December 2020

Alterations of calcium-regulatory proteins in heart failure.

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12 December 2020

Effects of a selective inhibitor of Na+/Ca2+ exchange, KB-R7943, on reoxygenation-induced injuries in guinea pig papillary muscles

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12 December 2020

[Effects of KB-R7943, a novel Na+/Ca2+ exchange inhibitor, on myocardial ischemia/reperfusion injury]

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12 December 2020

Amiloride in ouabain-induced acidification, inotropy and arrhythmia: 23Na & 31P NMR in perfused hearts

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12 December 2020

Effect of intracellular and extracellular pH on contraction in isolated, mammalian cardiac muscle

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12 December 2020

Electrical uncoupling and increase of extracellular resistance after induction of ischemia in isolated, arterially perfused rabbit papillary muscle.

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12 December 2020

Arrhythmogenesis and contractile dysfunction in heart failure: Roles of sodium-calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsiveness

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12 December 2020

Na/Ca exchange in heart failure: contractile dysfunction and arrhythmogenesis

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12 December 2020

Triggered activity and automaticity in ventricular trabeculae of failing human and rabbit hearts

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12 December 2020

The effect of exchanger inhibitory peptide (XIP) on sodium-calcium exchange current in guinea pig ventricular cells

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12 December 2020

Cardiac Na(+)-Ca(2+) exchange: molecular and pharmacological aspects

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12 December 2020

A novel isothiourea derivative selectively inhibits the reverse mode of Na+/Ca2+ exchange in cells expressing NCX1

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12 December 2020

Contribution of the Na(+) channel and Na(+)/H(+) exchanger to the anoxic rise of [Na(+)] in ventricular myocytes

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12 December 2020

Human myocardial Na,K-ATPase--quantification, regulation and relation to Ca.

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12 December 2020

Inhibition of Na+/Ca2+ exchange by KB-R7943: transport mode selectivity and antiarrhythmic consequences

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12 December 2020

Hypoxia increases persistent sodium current in rat ventricular myocytes.

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12 December 2020

Membrane electrical properties of vesicular Na-Ca exchange inhibitors in single atrial myocytes

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12 December 2020

Reperfusion-induced Ins(1,4,5)P(3) generation and arrhythmogenesis require activation of the Na(+)/Ca(2+) exchanger

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12 December 2020

Abnormal electrical activity induced by free radical generating systems in isolated cardiocytes

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12 December 2020

Relationship between Na+-Ca2+-exchanger protein levels and diastolic function of failing human myocardium.

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12 December 2020

Voltage dependence of sodium-calcium exchange current in guinea-pig atrial myocytes determined by means of an inhibitor

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12 December 2020

Low efficiency of Ca2+ entry through the Na(+)-Ca2+ exchanger as trigger for Ca2+ release from the sarcoplasmic reticulum. A comparison between L-type Ca2+ current and reverse-mode Na(+)-Ca2+ exchange

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12 December 2020

Electrophysiological mechanisms of ventricular arrhythmias resulting from myocardial ischemia and infarction

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12 December 2020

Sudden unexpected death in patients with congestive heart failure: a second frontier

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12 December 2020

Role of cardiac ATP-regulated potassium channels in differential responses of endocardial and epicardial cells to ischemia

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12 December 2020

Intracellular Na(+) concentration is elevated in heart failure but Na/K pump function is unchanged

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12 December 2020

Amiloride and its analogs as tools in the study of ion transport

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12 December 2020

Effects of components of ischemia and metabolic inhibition on delayed afterdepolarizations in guinea pig papillary muscle

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12 December 2020

Membrane potential fluctuations and transient inward currents induced by reactive oxygen intermediates in isolated rabbit ventricular cells

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12 December 2020

Changes in extracellular and intracellular pH in ischemic rabbit papillary muscle

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12 December 2020

KB-R7943 block of Ca(2+) influx via Na(+)/Ca(2+) exchange does not alter twitches or glycoside inotropy but prevents Ca(2+) overload in rat ventricular myocytes

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12 December 2020

Effect of amiloride on ischaemia and reperfusion injury in isolated, perfused rat hearts

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12 December 2020

Relaxation in rabbit and rat cardiac cells: species-dependent differences in cellular mechanisms

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12 December 2020

Quantification of [Ca2+]i in perfused hearts. Critical evaluation of the 5F-BAPTA and nuclear magnetic resonance method as applied to the study of ischemia and reperfusion

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12 December 2020

Effect of oral milrinone on mortality in severe chronic heart failure. The PROMISE Study Research Group

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12 December 2020

Inhibition of sodium-calcium exchange in cardiac sarcolemmal membrane vesicles. 1. Mechanism of inhibition by amiloride analogues.

1 reference

12 December 2020

Non-selective effects of amiloride and its analogues on ion transport systems and their cytotoxicities in cardiac myocytes

1 reference

12 December 2020

The role of L-type Ca2+ current and Na+ current-stimulated Na/Ca exchange in triggering SR calcium release in guinea-pig cardiac ventricular myocytes

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12 December 2020

Role of Na(+)/H(+) exchanger during ischemia and preconditioning in the isolated rat heart

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12 December 2020

Enhanced Ca(2+)-activated Na(+)-Ca(2+) exchange activity in canine pacing-induced heart failure

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12 December 2020

Amiloride derivatives are potent blockers of KATP channels

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12 December 2020

Effects of amiloride and an analogue on ventricular arrhythmias, contracture and cellular injury during reperfusion in isolated and perfused guinea pig heart

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12 December 2020

Na(+)-Ca(2+) exchange current and submembrane [Ca(2+)] during the cardiac action potential

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12 December 2020

Free radicals enhance Na+/Ca2+ exchange in ventricular myocytes

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12 December 2020

Simulation study of cellular electric properties in heart failure.

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12 December 2020

A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes

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12 December 2020

The sarcoplasmic reticulum and the Na+/Ca2+ exchanger both contribute to the Ca2+ transient of failing human ventricular myocytes

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12 December 2020

A novel antagonist, No. 7943, of the Na+/Ca2+ exchange current in guinea-pig cardiac ventricular cells

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12 December 2020

Upregulation of Na(+)/Ca(2+) exchanger expression and function in an arrhythmogenic rabbit model of heart failure

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12 December 2020

Electrophysiologic mechanisms underlying arrhythmias due to reperfusion of ischemic myocardium

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12 December 2020

Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, II: model studies

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12 December 2020

Reentrant and focal mechanisms underlying ventricular tachycardia in the human heart

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12 December 2020

Intracellular [Na+] and Na+ pump rate in rat and rabbit ventricular myocytes

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12 December 2020

Characterization of a [Ca2+]i-dependent current in human atrial and ventricular cardiomyocytes in the absence of Na+ and K+

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12 December 2020

Contribution of Na(+)-Ca2+ exchange to stimulation of transient inward current by isoproterenol in rabbit cardiac Purkinje fibers

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12 December 2020

Inhibition of Na+/Ca2+ exchange in membrane vesicle and papillary muscle preparations from guinea pig heart by analogs of amiloride

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12 December 2020

Inhibition and activation of Na+-Ca2+ exchange activity by quinacrine

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12 December 2020

Amiloride delays the ischemia-induced rise in cytosolic free calcium

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12 December 2020

Sodium-calcium exchange: a molecular perspective

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12 December 2020

Na-Ca exchange and the trigger for sarcoplasmic reticulum Ca release: studies in adult rabbit ventricular myocytes

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12 December 2020

Mechanisms of reoxygenation-induced calcium overload in cultured chick embryo heart cells

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12 December 2020

Gene expression of the cardiac Na(+)-Ca2+ exchanger in end-stage human heart failure

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12 December 2020

Nonreentrant mechanisms underlying spontaneous ventricular arrhythmias in a model of nonischemic heart failure in rabbits

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12 December 2020

Amiloride. Antiarrhythmic and electrophysiological activity in the dog

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12 December 2020

Knockout mice for pharmacological screening: testing the specificity of Na+-Ca2+ exchange inhibitors

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12 December 2020

Sodium/calcium exchange contributes to contraction and relaxation in failed human ventricular myocytes

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12 December 2020

Altered Na/Ca exchange activity in cardiac hypertrophy and heart failure: a new target for therapy?

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12 December 2020

Mechanisms underlying spontaneous and induced ventricular arrhythmias in patients with idiopathic dilated cardiomyopathy

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12 December 2020

Ca2+ influx during the cardiac action potential in guinea pig ventricular myocytes

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12 December 2020

Mechanisms underlying the development of ventricular fibrillation during early myocardial ischemia

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12 December 2020

Effects of fatty acids on Na+-Ca2+ exchange and Ca2+ permeability of cardiac sarcolemmal vesicles

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12 December 2020

Amiloride derivatives as blockers of Na+/Ca2+ exchange: effects on mechanical and electrical function of guinea-pig myocardium

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12 December 2020

Regulatory function of Na-Ca exchange in the heart: milestones and outlook

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12 December 2020

Stoichiometry of Na+-Ca2+ exchange in inside-out patches excised from guinea-pig ventricular myocytes

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12 December 2020

Role of Na+/Ca2+ exchange in endothelin-1-induced increases in Ca2+ transient and contractility in rabbit ventricular myocytes: pharmacological analysis with KB-R7943.

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12 December 2020

Effects of exogenous free radicals on electromechanical function and metabolism in isolated rabbit and guinea pig ventricle. Implications for ischemia and reperfusion injury

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12 December 2020

Reentrant and nonreentrant mechanisms contribute to arrhythmogenesis during early myocardial ischemia: results using three-dimensional mapping

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12 December 2020

Modelling myocardial ischaemia and reperfusion.

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12 December 2020

Very low dose of the Na(+)/Ca(2+) exchange inhibitor, KB-R7943, protects ischemic reperfused aged Fischer 344 rat hearts: considerable strain difference in the sensitivity to KB-R7943.

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12 December 2020

Study of the mechanisms of hydrogen peroxide and hydroxyl free radical-induced cellular injury and calcium overload in cardiac myocytes

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12 December 2020

The myocardial Na(+)-H(+) exchange: structure, regulation, and its role in heart disease

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12 December 2020

Direction-independent block of bi-directional Na+/Ca2+ exchange current by KB-R7943 in guinea-pig cardiac myocytes

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12 December 2020

Inhibitors of sodium-calcium exchange: identification and development of probes of transport activity

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12 December 2020

Cardiac Na/Ca exchange function in rabbit, mouse and man: what's the difference?

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12 December 2020

Enhanced Ca(2+) release and Na/Ca exchange activity in hypertrophied canine ventricular myocytes: potential link between contractile adaptation and arrhythmogenesis

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12 December 2020

Ischemia/reperfusion-induced arrhythmias in anaesthetized rats: a role of Na+ and Ca2+ influx.

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12 December 2020

Intracellular sodium accumulation during ischemia as the substrate for reperfusion injury

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12 December 2020

The stoichiometry of the cardiac sodium-calcium exchange system.

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12 December 2020

SEA0400, a novel and selective inhibitor of the Na+-Ca2+ exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic models.

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12 December 2020

Identification of a peptide inhibitor of the cardiac sarcolemmal Na(+)-Ca2+ exchanger

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12 December 2020

Effects of N-chlorobenzyl analogues of amiloride on myocardial contractility, Na-Ca-exchange carrier and other cardiac enzymatic activities.

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12 December 2020

Sodium/calcium exchange: its physiological implications

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12 December 2020

LabHEART: an interactive computer model of rabbit ventricular myocyte ion channels and Ca transport

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12 December 2020

Can Ca entry via Na-Ca exchange directly activate cardiac muscle contraction?

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12 December 2020

Effect of SEA0400, a novel inhibitor of sodium-calcium exchanger, on myocardial ionic currents

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12 December 2020

A Na+/Ca2+ exchanger inhibitor, KB-R7943, caused negative inotropic responses and negative followed by positive chronotropic responses in isolated, blood-perfused dog heart preparations.

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12 December 2020

The sodium-calcium ion membrane exchanger: physiologic significance and pharmacologic implications

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12 December 2020

Recent insights pertaining to sarcolemmal phospholipid alterations underlying arrhythmogenesis in the ischemic heart.

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12 December 2020

Cardioprotective effects of KB-R7943: a novel inhibitor of the reverse mode of Na+/Ca2+ exchanger

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12 December 2020

Dephosphorylation and intracellular redistribution of ventricular connexin43 during electrical uncoupling induced by ischemia

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12 December 2020

10.2165/00003495-200363050-00001

Identifiers

DOI

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PubMed ID

12600224

Dimensions Publication ID

6 August 2017

0 references

1 reference

PubMed ID

12600224