(Q35085026)

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An "exacerbate-reverse" strategy in yeast identifies histone deacetylase inhibition as a correction for cholesterol and sphingolipid transport defects in human Niemann-Pick type C disease

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Europe PubMed Central

PubMed publication ID

6 August 2017

An "exacerbate-reverse" strategy in yeast identifies histone deacetylase inhibition as a correction for cholesterol and sphingolipid transport defects in human Niemann-Pick type C disease (English)

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

1 reference

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author name string

Andrew B Munkacsi

1

1 reference

Europe PubMed Central

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6 August 2017

Fannie W Chen

2

1 reference

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6 August 2017

Matthew A Brinkman

3

1 reference

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6 August 2017

Katsumi Higaki

4

1 reference

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6 August 2017

Giselle Domínguez Gutiérrez

5

1 reference

Europe PubMed Central

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6 August 2017

Jagruti Chaudhari

6

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Jacob V Layer

7

1 reference

Europe PubMed Central

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6 August 2017

Amy Tong

8

1 reference

Europe PubMed Central

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6 August 2017

Martin Bard

9

1 reference

Europe PubMed Central

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6 August 2017

Charles Boone

10

1 reference

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6 August 2017

Yiannis A Ioannou

11

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6 August 2017

Stephen L Sturley

12

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6 August 2017

language of work or name

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publication date

13 April 2011

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6 August 2017

Journal of Biological Chemistry

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6 August 2017

286

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Europe PubMed Central

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6 August 2017

27

1 reference

Europe PubMed Central

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6 August 2017

23842-23851

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129166

8 July 2018

Niemann-Pick type C pathogenesis and treatment: from statins to sugars.

1 reference

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8 July 2018

Cyclodextrin induces calcium-dependent lysosomal exocytosis

1 reference

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8 July 2018

ScreenMill: a freely available software suite for growth measurement, analysis and visualization of high-throughput screen data

1 reference

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The SANT domain of p400 ATPase represses acetyltransferase activity and coactivator function of TIP60 in basal p21 gene expression

1 reference

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8 July 2018

Metabolic response to iron deficiency in Saccharomyces cerevisiae

1 reference

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8 July 2018

The genetic landscape of a cell

1 reference

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8 July 2018

Niemann-Pick type C disease proteins: orphan transporters or membrane rheostats?

1 reference

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8 July 2018

Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol

1 reference

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8 July 2018

Niemann-Pick C2 (NPC2) and intracellular cholesterol trafficking

1 reference

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8 July 2018

Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1-/- mouse

1 reference

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8 July 2018

Specific activity of class II histone deacetylases in human breast cancer cells

1 reference

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8 July 2018

Tritium suicide selection identifies proteins involved in the uptake and intracellular transport of sterols in Saccharomyces cerevisiae

1 reference

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8 July 2018

A comprehensive strategy enabling high-resolution functional analysis of the yeast genome.

1 reference

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8 July 2018

HDAC4 inhibits cell-cycle progression and protects neurons from cell death

1 reference

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8 July 2018

Functional dissection of the NuA4 histone acetyltransferase reveals its role as a genetic hub and that Eaf1 is essential for complex integrity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129166

8 July 2018

The Princeton Protein Orthology Database (P-POD): a comparative genomics analysis tool for biologists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129166

8 July 2018

Miglustat for treatment of Niemann-Pick C disease: a randomised controlled study

1 reference

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8 July 2018

Quantitative genetic analysis in Saccharomyces cerevisiae using epistatic miniarray profiles (E-MAPs) and its application to chromatin functions

1 reference

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8 July 2018

Microtubule deacetylases, SirT2 and HDAC6, in the nervous system

1 reference

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8 July 2018

The Saccharomyces cerevisiae Lipin homolog is a Mg2+-dependent phosphatidate phosphatase enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129166

8 July 2018

Histone deacetylase inhibitors: discovery and development as anticancer agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129166

8 July 2018

Saccharomyces cerevisiae Npc2p is a functionally conserved homologue of the human Niemann-Pick disease type C 2 protein, hNPC2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129166

8 July 2018

Binding between the Niemann-Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129166

8 July 2018

Elevated endosomal cholesterol levels in Niemann-Pick cells inhibit rab4 and perturb membrane recycling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129166

8 July 2018

Mutagenesis of the putative sterol-sensing domain of yeast Niemann Pick C-related protein reveals a primordial role in subcellular sphingolipid distribution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129166

8 July 2018

Identification of 58 novel mutations in Niemann-Pick disease type C: correlation with biochemical phenotype and importance of PTC1-like domains in NPC1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129166

8 July 2018

The integrity of a cholesterol-binding pocket in Niemann-Pick C2 protein is necessary to control lysosome cholesterol levels.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129166

8 July 2018

Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129166

8 July 2018

Telomerase immortalization upregulates Rab9 expression and restores LDL cholesterol egress from Niemann-Pick C1 late endosomes

1 reference

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 reference

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Systematic genetic analysis with ordered arrays of yeast deletion mutants

1 reference

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8 July 2018

NPC1 gene mutations in Japanese patients with Niemann-Pick disease type C

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129166

8 July 2018

A defect in cholesterol esterification in Niemann-Pick disease (type C) patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3129166

8 July 2018

Sites and temporal changes of gangliosides GM1/GM2 storage in the Niemann-Pick disease type C mouse brain.

1 reference

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21 January 2018

MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo

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Imatinib therapy blocks cerebellar apoptosis and improves neurological symptoms in a mouse model of Niemann-Pick type C disease

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Clues to neuro-degeneration in Niemann-Pick type C disease from global gene expression profiling

1 reference

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21 January 2018

Deregulation of cdk5, hyperphosphorylation, and cytoskeletal pathology in the Niemann-Pick type C murine model.

1 reference

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27 September 2018

Niemann-Pick C1 protein regulates cholesterol transport to the trans-Golgi network and plasma membrane caveolae.

1 reference

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Nystatin effects on vacuolar function in Saccharomyces cerevisiae

1 reference

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Defective cholesterol traffic and neuronal differentiation in neural stem cells of Niemann-Pick type C disease improved by valproic acid, a histone deacetylase inhibitor

1 reference

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1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M111.227645

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 August 2017

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