(Q35092551)

6 August 2017

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title

Congenic mice: cutting tools for complex immune disorders (English)

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6 August 2017

Ute C Rogner

1

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PubMed ID

12658272

6 August 2017

Philip Avner

series ordinal

2

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6 August 2017

1 March 2003

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Nature Reviews Immunology

6 August 2017

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6 August 2017

3

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6 August 2017

3

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6 August 2017

243-252

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The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases

6 August 2017

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Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases

31 March 2020

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From QTL to gene: the harvest begins

31 March 2020

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A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse

31 March 2020

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Genome-wide ENU mutagenesis to reveal immune regulators

31 March 2020

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31 March 2020

A mouse phenome project

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The roads from phenotypic variation to gene discovery: mutagenesis versus QTLs

31 March 2020

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Sequence interpretation. Functional annotation of mouse genome sequences

31 March 2020

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Functional genomic analysis of C. elegans chromosome I by systematic RNA interference

31 March 2020

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Systematic functional analysis of the Caenorhabditis elegans genome using RNAi

31 March 2020

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Identification of a new malaria susceptibility locus (Char4) in recombinant congenic strains of mice

31 March 2020

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The Human Genome Project--an overview

31 March 2020

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Analysing complex genetic traits with chromosome substitution strains

31 March 2020

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A new locus for resistance to gamma-radiation-induced thymic lymphoma identified using inter-specific consomic and inter-specific recombinant congenic strains of mice.

31 March 2020

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Speed congenics: a classic technique in the fast lane (relatively speaking).

31 March 2020

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A new mutation, gld, that produces lymphoproliferation and autoimmunity in C3H/HeJ mice

31 March 2020

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Type-I diabetes: a chronic autoimmune disease of human, mouse, and rat.

31 March 2020

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The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD.

31 March 2020

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The NOD mouse: recessive diabetogenic gene in the major histocompatibility complex

31 March 2020

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Understanding autoimmune diabetes: insights from mouse models.

31 March 2020

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CTLA-4-/- mice display T cell-apoptosis resistance resembling that ascribed to autoimmune-prone non-obese diabetic (NOD) mice

31 March 2020

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Type 1 diabetes and the control of dexamethazone-induced apoptosis in mice maps to the same region on chromosome 6

31 March 2020

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Genetic analysis of autoimmune disease

31 March 2020

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Mapping and analysis of quantitative trait loci in experimental populations

31 March 2020

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Genetic control of diabetogenesis in NOD/Lt mice. Development and analysis of congenic stocks.

31 March 2020

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Autoimmune syndromes in major histocompatibility complex (MHC) congenic strains of nonobese diabetic (NOD) mice. The NOD MHC is dominant for insulitis and cyclophosphamide-induced diabetes.

31 March 2020

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Linkage on chromosome 3 of autoimmune diabetes and defective Fc receptor for IgG in NOD mice.

31 March 2020

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Use of recombinant congenic and congenic strains of NOD mice to identify a new insulin-dependent diabetes resistance gene

31 March 2020

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Crosses of NOD mice with the related NON strain. A polygenic model for IDDM

31 March 2020

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Congenic mapping of the diabetogenic locus Idd4 to a 5.2-cM region of chromosome 11 in NOD mice: identification of two potential candidate subloci

31 March 2020

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Further mapping of the Idd5.1 locus for autoimmune diabetes in NOD mice

31 March 2020

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NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans.

31 March 2020

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Genome-tagged mice (GTM): two sets of genome-wide congenic strains

31 March 2020

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Theoretical and empirical issues for marker-assisted breeding of congenic mouse strains

31 March 2020

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ICA69(null) nonobese diabetic mice develop diabetes, but resist disease acceleration by cyclophosphamide.

31 March 2020

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B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice

31 March 2020

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A personal history of the mouse genome

31 March 2020

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Genetic analysis of diabetes and insulitis in an interspecific cross of the nonobese diabetic mouse with Mus spretus

31 March 2020

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The mosaic structure of variation in the laboratory mouse genome

31 March 2020

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Resistance alleles at two non-major histocompatibility complex-linked insulin-dependent diabetes loci on chromosome 3, Idd3 and Idd10, protect nonobese diabetic mice from diabetes

31 March 2020

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Localization of two insulin-dependent diabetes (Idd) genes to the Idd10 region on mouse Chromosome 3

31 March 2020

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The NOD Idd9 genetic interval influences the pathogenicity of insulitis and contains molecular variants of Cd30, Tnfr2, and Cd137.

31 March 2020

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Three Loci on Mouse Chromosome 6 Influence Onset and Final Incidence of Type I Diabetes in NOD.C3H Congenic Strains

31 March 2020

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Dissecting the architecture of a quantitative trait locus in yeast

31 March 2020

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The NOD mouse as a model of SLE.

31 March 2020

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Recombinant congenic strains derived from A/J and C57BL/6J: a tool for genetic dissection of complex traits

31 March 2020

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Genetic dissection of complex and quantitative traits: from fantasy to reality via a community effort

31 March 2020

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Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse chromosome 3: identification of a candidate segment of ancestral DNA by haplotype mapping

31 March 2020

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Identification of a new susceptibility locus for insulin-dependent diabetes mellitus by ancestral haplotype congenic mapping

31 March 2020

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Large-scale discovery and genotyping of single-nucleotide polymorphisms in the mouse

31 March 2020

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In silico mapping of complex disease-related traits in mice.

31 March 2020

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Functional screening of an asthma QTL in YAC transgenic mice.

31 March 2020

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Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

31 March 2020

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Functional genomics of the endocrine pancreas: the pancreas clone set and PancChip, new resources for diabetes research.

31 March 2020

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CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor

31 March 2020

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Gene expression profiling in immune cells using microarray.

31 March 2020

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High-quality RNA from cells isolated by laser capture microdissection

31 March 2020

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Molecular analysis of complex tissues is facilitated by laser capture microdissection: critical role of upstream tissue processing

31 March 2020

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Size matters: use of YACs, BACs and PACs in transgenic animals

31 March 2020

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Initial sequencing and comparative analysis of the mouse genome

31 March 2020

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Engineering chromosomal rearrangements in mice

31 March 2020

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Control of autoimmune diabetes in NOD mice by GAD expression or suppression in beta cells

31 March 2020

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Mouse BAC ends quality assessment and sequence analyses

31 March 2020

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An efficient method for high-fidelity BAC/PAC retrofitting with a selectable marker for mammalian cell transfection

31 March 2020

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Use of coisogenic host blastocysts for efficient establishment of germline chimeras with C57BL/6J ES cell lines

31 March 2020

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Establishment of an embryonic stem (ES) cell line derived from a non-obese diabetic (NOD) mouse: in vivo differentiation into lymphocytes and potential for germ line transmission

31 March 2020

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The derivation of highly germline-competent embryonic stem cells containing NOD-derived genome

31 March 2020

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RNA interference: antiviral defense and genetic tool

31 March 2020

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RNA interference in adult mice.

31 March 2020

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31 March 2020

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RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells

31 March 2020

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Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

31 March 2020

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On the role of RNA amplification in dsRNA-triggered gene silencing

31 March 2020

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A short primer on RNAi: RNA-directed RNA polymerase acts as a key catalyst

31 March 2020

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Evidence for linkage of a candidate chromosome 1 region to human systemic lupus erythematosus

31 March 2020

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The major murine systemic lupus erythematosus susceptibility locus Sle1 results in abnormal functions of both B and T cells

31 March 2020

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Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains.

31 March 2020

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Modeling allergic asthma in mice: pitfalls and opportunities

31 March 2020

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Bronchial asthma: lessons from murine models

31 March 2020

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Allergen-induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthma

31 March 2020

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Depletion of murine CD4+ T lymphocytes prevents antigen-induced airway hyperreactivity and pulmonary eosinophilia

31 March 2020

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Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model

31 March 2020

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Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family

31 March 2020

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Genetic influences on the end-stage effector phase of arthritis

31 March 2020

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The allelic structure of common disease

31 March 2020

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Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts

31 March 2020

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Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs

31 March 2020

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Genetics of systemic autoimmunity in mouse models of lupus

31 March 2020

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Looking at old tools in new ways: using knockouts as congenics to study QTLs

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1031

1 reference

6 August 2017

1 reference

PubMed ID

12658272