(Q35097997)

25541197

6 August 2017

title

Creating a monomeric endonuclease TALE-I-SceI with high specificity and low genotoxicity in human cells (English)

1 reference

6 August 2017

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25541197%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Kehkooi Kee

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25541197%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

author name string

Jianfei Lin

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25541197%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Ling Luo

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25541197%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Yongrong Lai

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25541197%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Wei Xie

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25541197%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

language of work or name

English

0 references

publication date

24 December 2014

1 reference

25541197

6 August 2017

published in

Nucleic Acids Research

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25541197%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

volume

43

1 reference

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12 June 2020

issue

2

1 reference

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12 June 2020

page(s)

1112-1122

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25541197%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution-NonCommercial 4.0 International

12 June 2020

copyright license

start time

7 November 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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1 reference

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Aptamer-guided gene targeting in yeast and human cells

9 July 2018

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megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering

9 July 2018

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Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity

9 July 2018

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CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity

9 July 2018

1 reference

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DNA targeting specificity of RNA-guided Cas9 nucleases

9 July 2018

1 reference

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High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

9 July 2018

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Gene therapy clinical trials worldwide to 2012 - an update.

9 July 2018

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RNA-guided human genome engineering via Cas9

9 July 2018

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RNA-guided genetic silencing systems in bacteria and archaea

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4333390

TAL effectors: customizable proteins for DNA targeting

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4333390

Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4333390

Genetic engineering of human pluripotent cells using TALE nucleases

9 July 2018

1 reference

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Enhancing zinc-finger-nuclease activity with improved obligate heterodimeric architectures

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4333390

Genome editing with engineered zinc finger nucleases

9 July 2018

1 reference

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Human DAZL, DAZ and BOULE genes modulate primordial germ-cell and haploid gamete formation

9 July 2018

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Fast and accurate short read alignment with Burrows-Wheeler transform

9 July 2018

1 reference

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Attenuation of zinc finger nuclease toxicity by small-molecule regulation of protein levels

9 July 2018

1 reference

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Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

9 July 2018

1 reference

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Terminally differentiated muscle cells are defective in base excision DNA repair and hypersensitive to oxygen injury.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4333390

Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4333390

An improved zinc-finger nuclease architecture for highly specific genome editing

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4333390

Positional stability of single double-strand breaks in mammalian cells

9 July 2018

1 reference

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Perturbed gap-filling synthesis in nucleotide excision repair causes histone H2AX phosphorylation in human quiescent cells

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4333390

The crystal structure of the gene targeting homing endonuclease I-SceI reveals the origins of its target site specificity

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4333390

Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4333390

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4333390

Genetic manipulation of genomes with rare-cutting endonucleases

9 July 2018

1 reference

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RNA guides genome engineering

9 July 2018

1 reference

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Heritable gene targeting in zebrafish using customized TALENs.

27 September 2018

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A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency

27 September 2018

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27 September 2018

Identifiers

DOI

10.1093/NAR/GKU1339

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25541197%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25541197%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

25541197

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25541197%20AND%20SRC:MED&resulttype=core&format=json