(Q35108293)

6 August 2017

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title

Protective mechanisms against the antitumor agent bleomycin: lessons from Saccharomyces cerevisiae (English)

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6 August 2017

main subject

Saccharomyces cerevisiae

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Dindial Ramotar

1

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6 August 2017

Huijie Wang

series ordinal

2

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6 August 2017

publication date

16 April 2003

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6 August 2017

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6 August 2017

volume

43

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6 August 2017

issue

4

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6 August 2017

page(s)

213-224

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Cleavage of Nucleic Acids by Bleomycin

6 August 2017

cites work

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12 December 2020

Wsc1 and Mid2 are cell surface sensors for cell wall integrity signaling that act through Rom2, a guanine nucleotide exchange factor for Rho1

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12 December 2020

A model for p53-induced apoptosis

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12 December 2020

Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage

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12 December 2020

Identification of APN2, the Saccharomyces cerevisiae homolog of the major human AP endonuclease HAP1, and its role in the repair of abasic sites

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12 December 2020

A role for Saccharomyces cerevisiae histone H2A in DNA repair.

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12 December 2020

Cellular resistance to bleomycin in Saccharomyces cerevisiae is not affected by changes in bleomycin hydrolase levels

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12 December 2020

Identification and characterization of SNQ2, a new multidrug ATP binding cassette transporter of the yeast plasma membrane.

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12 December 2020

Specific phosphorylation of SR proteins by mammalian DNA topoisomerase I.

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12 December 2020

Breaks and rejoining of DNA in cultured mammalian cells treated with bleomycin

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12 December 2020

The novel BLM3 gene encodes a protein that protects against lethal effects of oxidative damage

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12 December 2020

Copper-dependent cleavage of DNA by bleomycin

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12 December 2020

DNA methylation diminishes bleomycin-mediated strand scission

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12 December 2020

Copper(I) . bleomycin. A structurally unique oxidation-reduction active complex

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12 December 2020

Altered drug sensitivities to anticancer agents in radiation-sensitive DNA repair deficient yeast mutants.

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12 December 2020

Cellular role of yeast Apn1 apurinic endonuclease/3'-diesterase: repair of oxidative and alkylation DNA damage and control of spontaneous mutation

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12 December 2020

BLH1 codes for a yeast thiol aminopeptidase, the equivalent of mammalian bleomycin hydrolase.

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12 December 2020

Mutational analysis of the Saccharomyces cerevisiae ATP-binding cassette transporter protein Ycf1p

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12 December 2020

A role for ferrous ion and oxygen in the degradation of DNA by bleomycin

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12 December 2020

A yeast gene (BLH1) encodes a polypeptide with high homology to vertebrate bleomycin hydrolase, a family member of thiol proteinases

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12 December 2020

Cloning and characterization of a cysteine proteinase from Saccharomyces cerevisiae

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12 December 2020

Specific cleavage of a DNA triple helix by FeII.bleomycin

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12 December 2020

Bleomycin and other antitumor antibiotics of high molecular weight

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12 December 2020

Genotoxicity of bleomycin

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12 December 2020

Copper(II) facilitates bleomycin-mediated unwinding of plasmid DNA.

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12 December 2020

Activated bleomycin. A transient complex of drug, iron, and oxygen that degrades DNA

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12 December 2020

Kinetics of the reaction of bleomycin-Fe(II)-O2 complex with DNA.

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12 December 2020

Natural and artificial bleomycins: chemistry and antitumor activities

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12 December 2020

Study of bleomycin on brain tumors. 1. Inhibitory effect of bleomycin on cultured brain tumor cells

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12 December 2020

Bleomycin-induced strand-scission of DNA. Mechanism of deoxyribose cleavage

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12 December 2020

Crystal structure of a conserved protease that binds DNA: the bleomycin hydrolase, Gal6

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12 December 2020

Effect of chelating agents and metal ions on the degradation of DNA by bleomycin

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12 December 2020

Effects of Reducing and Oxidizing Agents on the Action of Bleomycin1

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12 December 2020

Identification of a plasma membrane protein that specifically binds bleomycin

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12 December 2020

Association of distinct yeast Not2 functional domains with components of Gcn5 histone acetylase and Ccr4 transcriptional regulatory complexes

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12 December 2020

Bleomycin Treatment of the Tumors of Penis and Scrotum

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12 December 2020

Yeast bleomycin hydrolase is a DNA-binding cysteine protease. Identification, purification, biochemical characterization.

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12 December 2020

The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme

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12 December 2020

Human bleomycin hydrolase: molecular cloning, sequencing, functional expression, and enzymatic characterization

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12 December 2020

Saccharomyces cerevisiae basic region-leucine zipper protein regulatory networks converge at the ATR1 structural gene

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12 December 2020

Lethal effect of bleomycin on cultured mammalian cells

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12 December 2020

Copper(I)-bleomycin: structurally unique complex that mediates oxidative DNA strand scission

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12 December 2020

AP1-mediated multidrug resistance in Saccharomyces cerevisiae requires FLR1 encoding a transporter of the major facilitator superfamily

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12 December 2020

Disruption of the Saccharomyces cerevisiae cell-wall pathway gene SLG1 causes hypersensitivity to the antitumor drug bleomycin

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12 December 2020

The redox state of activated bleomycin

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12 December 2020

Expression of the Saccharomyces cerevisiae DNA repair gene RAD6 that encodes a ubiquitin conjugating enzyme, increases in response to DNA damage and in meiosis but remains constant during the mitotic cell cycle

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12 December 2020

Binding of bleomycin to DNA in bleomycin-sensitive and -resistant rat ascites hepatoma cells

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12 December 2020

Effect of antibody against integrin alpha4 on bleomycin-induced pulmonary fibrosis in mice.

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12 December 2020

A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates signalling by protein kinase C.

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12 December 2020

The complexity of p53 modulation: emerging patterns from divergent signals

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12 December 2020

On the chemistry of RNA degradation by Fe.bleomycin

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12 December 2020

Partial purification of Pde1 from Saccharomyces cerevisiae: enzymatic redundancy for the repair of 3'-terminal DNA lesions and abasic sites in yeast

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12 December 2020

Multiple Pdr1p/Pdr3p binding sites are essential for normal expression of the ATP binding cassette transporter protein-encoding gene PDR5.

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12 December 2020

On the mechanism of action of bleomycin. Strand scission of DNA caused by bleomycin and its binding to DNA in vitro.

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12 December 2020

New antibiotics, bleomycin A and B

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12 December 2020

Comparative roles of the cell wall and cell membrane in limiting uptake of xenobiotic molecules by Saccharomyces cerevisiae

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12 December 2020

IMP2, a gene involved in the expression of glucose-repressible genes in Saccharomyces cerevisiae

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12 December 2020

The multidrug resistance transporters of the major facilitator superfamily, 6 years after disclosure of Saccharomyces cerevisiae genome sequence

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12 December 2020

The ratio of single- to double-strand DNA breaks and their absolute values determine cell death pathway

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12 December 2020

A plant surface protein sharing structural properties with animal integrins

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12 December 2020

A bleomycin-inactivating enzyme in mouse liver

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12 December 2020

Neutralization of bleomycin hydrolase by an epitope-specific antibody

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12 December 2020

HDF2, the second subunit of the Ku homologue from Saccharomyces cerevisiae.

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12 December 2020

RNA degradation by bleomycin, a naturally occurring bioconjugate

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12 December 2020

Dominant mutations in a gene encoding a putative protein kinase (BCK1) bypass the requirement for a Saccharomyces cerevisiae protein kinase C homolog

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12 December 2020

Origin of malondialdehyde from DNA degraded by Fe(II) x bleomycin

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12 December 2020

Large-scale analysis of gene expression, protein localization, and gene disruption in Saccharomyces cerevisiae

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12 December 2020

A family of genes required for maintenance of cell wall integrity and for the stress response in Saccharomyces cerevisiae

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12 December 2020

Bleomycin hydrolase is a unique thiol aminopeptidase

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12 December 2020

The neutral cysteine protease bleomycin hydrolase is essential for epidermal integrity and bleomycin resistance

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12 December 2020

The proliferation of MAP kinase signaling pathways in yeast.

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12 December 2020

Mutants in the S. cerevisiae PKC1 gene display a cell cycle-specific osmotic stability defect

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12 December 2020

High dose continuous infusion of bleomycin in mice: a new model for drug-induced pulmonary fibrosis.

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12 December 2020

Characterization of iron (II).bleomycin-mediated RNA strand scission

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12 December 2020

Metal binding to modified bleomycins. Zinc and ferrous complexes with an acetylated bleomycin

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12 December 2020

Mechanism of action of bleomycin. Studies with the growing culture of bacterial and tumor cells

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12 December 2020

Further characterizations of bleomycin-sensitive (blm) mutants of Saccharomyces cerevisiae with implications for a radiomimetic model

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12 December 2020

Site-specific cleavage of RNA by Fe(II).bleomycin

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12 December 2020

Induced mutagenesis by bleomycin in the purple sulfur bacterium Thiocapsa roseopersicina

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12 December 2020

Allelism of IMP1 and GAL2 genes of Saccharomyces cerevisiae

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12 December 2020

Cleavage of tRNA by Fe(II)-bleomycin

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12 December 2020

Properties and products of the degradation of DNA by bleomycin and iron(II)

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12 December 2020

Curing metastatic testicular cancer

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12 December 2020

The products of YCF1 and YLL015w (BPT1) cooperate for the ATP-dependent vacuolar transport of unconjugated bilirubin in Saccharomyces cerevisiae

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12 December 2020

A structural basis of the interactions between leucine-rich repeats and protein ligands

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12 December 2020

Metabolic inactivation: a mechanism of human tumor resistance to bleomycin.

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12 December 2020

Yeast structural gene (APN1) for the major apurinic endonuclease: homology to Escherichia coli endonuclease IV

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12 December 2020

Uncoupling of 3'-phosphatase and 5'-kinase functions in budding yeast. Characterization of Saccharomyces cerevisiae DNA 3'-phosphatase (TPP1).

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12 December 2020

Sequence-specific double-strand cleavage of DNA by Fe-bleomycin. 2. Mechanism and dynamics

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12 December 2020

Internalisation of the bleomycin molecules responsible for bleomycin toxicity: a receptor-mediated endocytosis mechanism

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12 December 2020

The transcriptional activator Imp2p maintains ion homeostasis in Saccharomyces cerevisiae

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12 December 2020

Metabolic inactivation of bleomycin analogs by bleomycin hydrolase

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12 December 2020

A Saccharomyces cerevisiae mutant defines a new locus essential for resistance to the antitumour drug bleomycin

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12 December 2020

Free-radical mechanisms involved in the formation of sequence-dependent bistranded DNA lesions by the antitumor antibiotics bleomycin, neocarzinostatin, and calicheamicin

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12 December 2020

In vivo circumvention of human colon carcinoma resistance to bleomycin

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12 December 2020

Lipid peroxidation by bleomycin-iron complexes in vitro

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12 December 2020

Complementation of DNA repair-deficient Escherichia coli by the yeast Apn1 apurinic/apyrimidinic endonuclease gene

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12 December 2020

Polynucleotide recognition and degradation by bleomycin

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12 December 2020

Isotope effects on the cleavage of DNA by bleomycin: mechanism and modulation

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12 December 2020

YAP1 confers resistance to the fatty acid synthase inhibitor cerulenin through the transporter Flr1p in Saccharomyces cerevisiae.

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12 December 2020

Synthesis of key analogs of bleomycin A2 that permit a systematic evaluation of the linker region: identification of an exceptionally prominent role for the L-threonine substituent

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12 December 2020

Complete inventory of the yeast ABC proteins

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12 December 2020

Iron(II) Bleomycin-Mediated Degradation of a DNA-RNA Heteroduplex

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12 December 2020

Iron-bleomycin interactions with oxygen and oxygen analogues. Effects on spectra and drug activity

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12 December 2020

Biochemical and cellular determinants of bleomycin cytotoxicity

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12 December 2020

Effects of bleomycin on growth kinetics and survival of Saccharomyces cerevisiae: a model of repair pathways

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12 December 2020

Yeast cysteine proteinase gene ycp1 induces resistance to bleomycin in mammalian cells

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12 December 2020

Bleomycin-resistant cells contain increased bleomycin-hydrolase activities

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12 December 2020

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12 December 2020

Bleomycin-induced DNA lesions at mutational hot spots: implications for the mechanism of double-strand cleavage

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12 December 2020

Metallobleomycin-DNA interactions: structures and reactions related to bleomycin-induced DNA damage.

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12 December 2020

Altered expression of Ape1/ref-1 in germ cell tumors and overexpression in NT2 cells confers resistance to bleomycin and radiation.

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12 December 2020

DNA double-strand breaks and alkali-labile bonds produced by bleomycin

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12 December 2020

MKK1 and MKK2, which encode Saccharomyces cerevisiae mitogen-activated protein kinase-kinase homologs, function in the pathway mediated by protein kinase C

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12 December 2020

Sequence-specific hydrolysis of yeast tRNA(Phe) mediated by metal-free bleomycin

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12 December 2020

On the role of the bithiazole moiety in sequence-selective DNA cleavage by Fe.bleomycin

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12 December 2020

Human bleomycin hydrolase binds ribosomal proteins

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12 December 2020

Properties of redox-inactivated bleomycins. In vitro DNA damage and inhibition of Ehrlich cell proliferation

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12 December 2020

The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution

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12 December 2020

Stoichiometry of DNA strand scission and aldehyde formation by bleomycin

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12 December 2020

A role for the Pkc1 MAP kinase pathway of Saccharomyces cerevisiae in bud emergence and identification of a putative upstream regulator

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12 December 2020

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12 December 2020

Functional mitochondria are essential for Saccharomyces cerevisiae cellular resistance to bleomycin

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12 December 2020

Deletions at short direct repeats and base substitutions are characteristic mutations for bleomycin-induced double- and single-strand breaks, respectively, in a human shuttle vector system

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12 December 2020

Solid-phase synthesis of bleomycin group antibiotics. Elaboration of deglycobleomycin A(5).

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12 December 2020

Indirect mutagenesis by oxidative DNA damage: formation of the pyrimidopurinone adduct of deoxyguanosine by base propenal

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12 December 2020

In vivo sensitization of human lung carcinoma to bleomycin by the cysteine proteinase inhibitor E-64

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12 December 2020

Lack of metabolism as the biochemical basis of bleomycin-induced pulmonary toxicity

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12 December 2020

Effect of in vitro cleavage of apurinic/apyrimidinic sites on bleomycin-induced mutagenesis of repackaged lambda phage

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12 December 2020

Establishment of human squamous carcinoma cell lines highly and minimally sensitive to bleomycin and analysis of factors involved in the sensitivity

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12 December 2020

Coordinated regulation of gene expression by the cell cycle transcription factor Swi4 and the protein kinase C MAP kinase pathway for yeast cell integrity

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12 December 2020

Effects of O2 on the reactions of activated bleomycin

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12 December 2020

Mechanism of bleomycin action: studies

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12 December 2020

Frequencies of HPRT mutants and micronuclei in lymphocytes of cancer patients under chemotherapy: a prospective study

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12 December 2020

Mutational disruption of plasma membrane trafficking of Saccharomyces cerevisiae Yor1p, a homologue of mammalian multidrug resistance protein

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12 December 2020

Treatment of lung cancer with bleomycin. II.

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12 December 2020

The Saccharomyces cerevisiae ETH1 gene, an inducible homolog of exonuclease III that provides resistance to DNA-damaging agents and limits spontaneous mutagenesis

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12 December 2020

Response of a murine solid tumor to in vivo combined chemotherapy and irradiation.

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12 December 2020

Fe.bleomycin cleaves a transfer RNA precursor and its "transfer DNA" analog at the same major site.

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12 December 2020

DNA strand scission by activated bleomycin group antibiotics

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12 December 2020

A Saccharomyces cerevisiae phleomycin-sensitive mutant, ph140, is defective in the RAD6 DNA repair gene

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12 December 2020

The leucine-rich repeat: a versatile binding motif

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12 December 2020

Degradation of structurally modified DNAs by bleomycin group antibiotics

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12 December 2020

An allele of the yeast RPB7 gene, encoding an essential subunit of RNA polymerase II, reduces cellular resistance to the antitumor drug bleomycin

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12 December 2020

Integrins: redundant or important players in skeletal muscle?

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12 December 2020

Solution structure of Co(III)-bleomycin-OOH bound to a phosphoglycolate lesion containing oligonucleotide: implications for bleomycin-induced double-strand DNA cleavage

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12 December 2020

The cysteine-peptidase bleomycin hydrolase is a member of the galactose regulon in yeast

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12 December 2020

A pivotal role of cytosolic phospholipase A(2) in bleomycin-induced pulmonary fibrosis

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12 December 2020

The unusual active site of Gal6/bleomycin hydrolase can act as a carboxypeptidase, aminopeptidase, and peptide ligase

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12 December 2020

Alteration and activation of sequence-specific cleavage of DNA by bleomycin in the presence of the antitumor drug cis-diamminedichloroplatinum(II)

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12 December 2020

Sequence-specific double-strand cleavage of DNA by Fe-bleomycin. 1. The detection of sequence-specific double-strand breaks using hairpin oligonucleotides

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12 December 2020

The Saccharomyces cerevisiae IMP2 gene encodes a transcriptional activator that mediates protection against DNA damage caused by bleomycin and other oxidants

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12 December 2020

Involvement of the Saccharomyces cerevisiae HDF1 gene in DNA double-strand break repair and recombination.

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12 December 2020

Homogeneous Escherichia coli endonuclease IV. Characterization of an enzyme that recognizes oxidative damage in DNA

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12 December 2020

Spontaneous cleavage of bleomycin-induced abasic sites in chromatin and their mutagenicity in mammalian shuttle vectors

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12 December 2020

Induction of micronuclei by bleomycin in G0 human lymphocytes: I. Dose-response and distribution

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12 December 2020

Exonuclease III and endonuclease IV remove 3' blocks from DNA synthesis primers in H2O2-damaged Escherichia coli

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12 December 2020

In vitro detection of endonuclease IV-specific DNA damage formed by bleomycin in vivo

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12 December 2020

The repair of double-strand breaks in the nuclear DNA of Saccharomyces cerevisiae and its genetic control

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12 December 2020

10.1007/S00294-003-0396-1

Identifiers

DOI

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release_vsiuze5kcfdjxedynpg6ypmfum

6 August 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/vsiuze5kcfdjxedynpg6ypmfum

24 November 2022

mapped directly with Wikidata item

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