(Q35111461)

English

FM19G11 reverses endothelial dysfunction in rat and human arteries through stimulation of the PI3K/Akt/eNOS pathway, independently of mTOR/HIF-1α activation.

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scholarly article

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25363469%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

FM19G11 reverses endothelial dysfunction in rat and human arteries through stimulation of the PI3K/Akt/eNOS pathway, independently of mTOR/HIF-1α activation (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25363469%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

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José M Sánchez-Puelles

2

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22 February 2020

José Luis Aceña

6

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22 February 2020

Leocadio Rodríguez-Mañas

7

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22 February 2020

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M El Assar

1

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22 February 2020

I Royo

3

1 reference

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22 February 2020

E López-Hernández

4

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22 February 2020

A Sánchez-Ferrer

5

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22 February 2020

J Angulo

8

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22 February 2020

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12 January 2015

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22 February 2020

British Journal of Pharmacology

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22 February 2020

172

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22 February 2020

5

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22 February 2020

1277-1291

1 reference

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22 February 2020

The Concise Guide to PHARMACOLOGY 2013/14: enzymes.

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9 July 2018

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

1 reference

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9 July 2018

A systematic review of the association between erectile dysfunction and cardiovascular disease

1 reference

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9 July 2018

Differential regulation of pulmonary vascular cell growth by hypoxia-inducible transcription factor-1α and hypoxia-inducible transcription factor-2α.

1 reference

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9 July 2018

Ca2+ -activated K+ channel (KCa) stimulation improves relaxant capacity of PDE5 inhibitors in human penile arteries and recovers the reduced efficacy of PDE5 inhibition in diabetic erectile dysfunction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4337701

9 July 2018

Oxygen-independent regulation of HIF-1: novel involvement of PI3K/AKT/mTOR pathway in cancer

1 reference

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9 July 2018

Insulin resistance and coronary heart disease in nondiabetic individuals

1 reference

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9 July 2018

Ceramide mediates vascular dysfunction in diet-induced obesity by PP2A-mediated dephosphorylation of the eNOS-Akt complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4337701

9 July 2018

Fasting and post-glucose load measures of insulin resistance and risk of ischemic stroke in older adults

1 reference

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9 July 2018

Flow-mediated dilation and cardiovascular event prediction: does nitric oxide matter?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4337701

9 July 2018

Hypoxia-inducible factors and the response to hypoxic stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4337701

9 July 2018

FM19G11: A new modulator of HIF that links mTOR activation with the DNA damage checkpoint pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4337701

9 July 2018

Animal research: reporting in vivo experiments: the ARRIVE guidelines

1 reference

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9 July 2018

Guidelines for reporting experiments involving animals: the ARRIVE guidelines

1 reference

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9 July 2018

Anatomy, physiology, and pathophysiology of erectile dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4337701

9 July 2018

Cellular signaling and NO production

1 reference

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9 July 2018

FM19G11, a new hypoxia-inducible factor (HIF) modulator, affects stem cell differentiation status.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4337701

9 July 2018

The fructose-fed rat: a review on the mechanisms of fructose-induced insulin resistance and hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4337701

9 July 2018

Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4337701

9 July 2018

Differential dependence of hypoxia-inducible factors 1 alpha and 2 alpha on mTORC1 and mTORC2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4337701

9 July 2018

Resistin impairs insulin-evoked vasodilation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4337701

9 July 2018

The PI3-K/Akt pathway: roles related to alterations in vasomotor responses in diabetic models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4337701

9 July 2018

Insulin receptor substrate-1 and phosphoinositide-dependent kinase-1 are required for insulin-stimulated production of nitric oxide in endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4337701

9 July 2018

Regulation of human penile smooth muscle tone by prostanoid receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4337701

9 July 2018

Estrogen induces the Akt-dependent activation of endothelial nitric-oxide synthase in vascular endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4337701

9 July 2018

Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2- imbalance in insulin-resistant rat aorta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4337701

9 July 2018

cGMP mediates the vascular and platelet actions of nitric oxide: confirmation using an inhibitor of the soluble guanylyl cyclase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4337701

9 July 2018

Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4337701

9 July 2018

Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4337701

9 July 2018

Diabetes exacerbates the functional deficiency of NO/cGMP pathway associated with erectile dysfunction in human corpus cavernosum and penile arteries

1 reference

https://api.crossref.org/works/10.1111%2FBPH.12993

21 January 2018

Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia

1 reference

https://api.crossref.org/works/10.1111%2FBPH.12993

21 January 2018

Impaired cross-activation of β3 integrin and VEGFR-2 on endothelial progenitor cells with aging decreases angiogenesis in response to hypoxia.

1 reference

https://api.crossref.org/works/10.1111%2FBPH.12993

21 January 2018

Insulin resistance functionally limits endothelium-dependent coronary vasodilation in nondiabetic patients

1 reference

https://api.crossref.org/works/10.1111%2FBPH.12993

21 January 2018

Peripheral atherosclerosis in patients with arterial erectile dysfunction

1 reference

https://api.crossref.org/works/10.1111%2FBPH.12993

21 January 2018

Homeostasis model assessment of insulin resistance in relation to the incidence of cardiovascular disease: the San Antonio Heart Study

1 reference

https://api.crossref.org/works/10.1111%2FBPH.12993

21 January 2018

Erectile dysfunction and asymptomatic coronary artery disease: frequently detected by computed tomography coronary angiography but not by exercise electrocardiography

1 reference

https://api.crossref.org/works/10.1111%2FBPH.12993

21 January 2018

EDHF-mediated relaxation is impaired in fructose-fed rats.

1 reference

https://api.crossref.org/works/10.1111%2FBPH.12993

21 January 2018

Impairment of PI3-K/Akt pathway underlies attenuated endothelial function in aorta of type 2 diabetic mouse model

1 reference

https://api.crossref.org/works/10.1111%2FBPH.12993

21 January 2018

Vascular insulin resistance in prehypertensive rats: role of PI3-kinase/Akt/eNOS signaling

1 reference

https://api.crossref.org/works/10.1111%2FBPH.12993

21 January 2018

Obesity, insulin resistance, and the metabolic syndrome: determinants of endothelial dysfunction in whites and blacks

1 reference

https://api.crossref.org/works/10.1111%2FBPH.12993

21 January 2018

Role of endothelial nitric oxide in shear stress-induced vasodilation of human microvasculature: diminished activity in hypertensive and hypercholesterolemic patients

1 reference

https://api.crossref.org/works/10.1111%2FBPH.12993

21 January 2018

FM19G11 favors spinal cord injury regeneration and stem cell self-renewal by mitochondrial uncoupling and glucose metabolism induction

1 reference

https://api.crossref.org/works/10.1111%2FBPH.12993

21 January 2018

Early and intermediate Amadori glycosylation adducts, oxidative stress, and endothelial dysfunction in the streptozotocin-induced diabetic rats vasculature

1 reference

https://api.crossref.org/works/10.1111%2FBPH.12993

21 January 2018

Endothelial dysfunction in aged humans is related with oxidative stress and vascular inflammation

1 reference

https://api.crossref.org/works/10.1111%2FBPH.12993

21 January 2018

Hypoxia-inducible factor-1 improves inotropic responses of cardiac myocytes in ageing heart without affecting mitochondrial activity

1 reference

https://api.crossref.org/works/10.1111%2FBPH.12993

21 January 2018

Biochemical and pharmacological studies with KT7692 and LY294002 on the role of phosphatidylinositol 3-kinase in Fc epsilon RI-mediated signal transduction

1 reference

https://api.crossref.org/works/10.1111%2FBPH.12993

21 January 2018

Phosphorylation and activation of the endothelial nitric oxide synthase by fluid shear stress

1 reference

https://api.crossref.org/works/10.1111%2FBPH.12993

21 January 2018

Impairment of Endothelium-Dependent Relaxation by Increasing Percentages of Glycosylated Human Hemoglobin

1 reference

https://pubmed.ncbi.nlm.nih.gov/25363469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association between insulin resistance and endothelial dysfunction in type 2 diabetes and the effects of pioglitazone

1 reference

https://pubmed.ncbi.nlm.nih.gov/25363469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapamycin inhibits hydrogen peroxide-induced loss of vascular contractility

1 reference

https://pubmed.ncbi.nlm.nih.gov/25363469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia-Inducible Factor 1 Alpha Contributes to Cardiac Healing in Mesenchymal Stem Cells-Mediated Cardiac Repair

1 reference

https://pubmed.ncbi.nlm.nih.gov/25363469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/BPH.12993

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25363469%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25363469%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25363469%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

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