(Q35114316)

6 August 2017

Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability (English)

1 reference

amyotrophic lateral sclerosis

6 August 2017

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25580746%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Joshua D. Foster

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25580746%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Ludovic Vallier

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25580746%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Christopher Shaw

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25580746%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Siddharthan Chandran

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25580746%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Gareth B. Miles

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25580746%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

author name string

Karen Burr

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25580746%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Shyamanga Borooah

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25580746%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Elaine M Cleary

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25580746%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Imbisaat Geti

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25580746%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

language of work or name

English

0 references

publication date

12 January 2015

1 reference

6 August 2017

Nature Communications

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25580746%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

volume

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25580746%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

page(s)

5999

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25580746%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

13 June 2020

copyright license

start time

12 January 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1038/ncomms6999

0 references

cites work

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Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons

9 July 2018

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Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations

9 July 2018

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9 July 2018

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Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion

9 July 2018

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Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations.

9 July 2018

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RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention

9 July 2018

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Modeling key pathological features of frontotemporal dementia with C9ORF72 repeat expansion in iPSC-derived human neurons

9 July 2018

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Selective mitochondrial Ca2+ uptake deficit in disease endstage vulnerable motoneurons of the SOD1G93A mouse model of amyotrophic lateral sclerosis

9 July 2018

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ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43.

9 July 2018

1 reference

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Accelerated high-yield generation of limb-innervating motor neurons from human stem cells

9 July 2018

1 reference

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Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs

9 July 2018

1 reference

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Gender-specific perturbations in modulatory inputs to motoneurons in a mouse model of amyotrophic lateral sclerosis.

9 July 2018

1 reference

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The genetics and neuropathology of amyotrophic lateral sclerosis

9 July 2018

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Drug screening for ALS using patient-specific induced pluripotent stem cells

9 July 2018

1 reference

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Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability

9 July 2018

1 reference

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Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice

9 July 2018

1 reference

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Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells

9 July 2018

1 reference

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A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

9 July 2018

1 reference

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Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS

9 July 2018

1 reference

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Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients

9 July 2018

1 reference

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Characterizing the RNA targets and position-dependent splicing regulation by TDP-43.

9 July 2018

1 reference

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Misfolded mutant SOD1 directly inhibits VDAC1 conductance in a mouse model of inherited ALS

9 July 2018

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A cluster of cholinergic premotor interneurons modulates mouse locomotor activity

9 July 2018

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Progressive changes in synaptic inputs to motoneurons in adult sacral spinal cord of a mouse model of amyotrophic lateral sclerosis

9 July 2018

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Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

9 July 2018

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Glycinergic innervation of motoneurons is deficient in amyotrophic lateral sclerosis mice: a quantitative confocal analysis

9 July 2018

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Increased persistent sodium current determines cortical hyperexcitability in a genetic model of amyotrophic lateral sclerosis

9 July 2018

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Cu/Zn superoxide dismutase typical for familial amyotrophic lateral sclerosis increases the vulnerability of mitochondria and perturbs Ca2+ homeostasis in SOD1G93A mice

9 July 2018

1 reference

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Neonatal neuronal circuitry shows hyperexcitable disturbance in a mouse model of the adult-onset neurodegenerative disease amyotrophic lateral sclerosis

9 July 2018

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Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons

9 July 2018

1 reference

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TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis

9 July 2018

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Lost in translation: treatment trials in the SOD1 mouse and in human ALS.

9 July 2018

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Spinal cholinergic interneurons regulate the excitability of motoneurons during locomotion

9 July 2018

1 reference

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Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

9 July 2018

1 reference

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Altered axonal excitability properties in amyotrophic lateral sclerosis: impaired potassium channel function related to disease stage

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338554

Neuroprotection through excitability and mTOR required in ALS motoneurons to delay disease and extend survival.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338554

Altered postnatal maturation of electrical properties in spinal motoneurons in a mouse model of amyotrophic lateral sclerosis.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338554

Low Ca2+ buffering in hypoglossal motoneurons of mutant SOD1 (G93A) mice.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338554

Cortical hyperexcitability may precede the onset of familial amyotrophic lateral sclerosis.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338554

Voltage-dependent sodium channels in spinal cord motor neurons display rapid recovery from fast inactivation in a mouse model of amyotrophic lateral sclerosis.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338554

Axonal excitability properties in amyotrophic lateral sclerosis

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338554

Imbalanced excitatory to inhibitory synaptic input precedes motor neuron degeneration in an animal model of amyotrophic lateral sclerosis

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338554

Increased persistent Na(+) current and its effect on excitability in motoneurones cultured from mutant SOD1 mice.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338554

Altered excitability of motor neurons in a transgenic mouse model of familial amyotrophic lateral sclerosis.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338554

Increased nodal persistent Na+ currents in human neuropathy and motor neuron disease estimated by latent addition

27 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS6999

Adult spinal motoneurones are not hyperexcitable in a mouse model of inherited amyotrophic lateral sclerosis

21 January 2018

1 reference

12 December 2020

Global loss of Na,K-ATPase and its nitric oxide-mediated regulation in a transgenic mouse model of amyotrophic lateral sclerosis

1 reference

12 December 2020

Synaptic pathology of spinal anterior horn cells in amyotrophic lateral sclerosis: an immunohistochemical study

1 reference

12 December 2020

Synapse loss in anterior horn neurons in amyotrophic lateral sclerosis

1 reference

12 December 2020

Axonal ion channel dysfunction in amyotrophic lateral sclerosis

1 reference

12 December 2020

Quantitative study of synaptophysin immunoreactivity of cerebral cortex and spinal cord in motor neuron disease

1 reference

12 December 2020

Early electrophysiological abnormalities in lumbar motoneurons in a transgenic mouse model of amyotrophic lateral sclerosis

1 reference

12 December 2020

Increase in presynaptic territory of C-terminals on lumbar motoneurons of G93A SOD1 mice during disease progression

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCOMMS6999

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25580746%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

13 June 2020

ADS bibcode

2015NatCo...6.5999D

0 references

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25580746%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25580746%20AND%20SRC:MED&resulttype=core&format=json