(Q35116376)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12719002%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

review article

1 reference

title

Approaching a new era for hepatitis C virus therapy: inhibitors of the NS3-4A serine protease and the NS5B RNA-dependent RNA polymerase (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12719002%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

1 reference

1 reference

Raffaele De Francesco

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12719002%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

author name string

Licia Tomei

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12719002%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

Sergio Altamura

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12719002%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

Vincenzo Summa

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12719002%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

Giovanni Migliaccio

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12719002%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

language of work or name

1 reference

1 March 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12719002%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12719002%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

volume

58

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12719002%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12719002%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

page(s)

1-16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12719002%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Expression of recombinant hepatitis C virus non-structural protein 5B in Escherichia coli

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

The solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Hepatitis C virus replicons: potential role for drug development

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Novel cell culture systems for the hepatitis C virus

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Substrate determinants for cleavage in cis and in trans by the hepatitis C virus NS3 proteinase

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

The identification of alpha-ketoamides as potent inhibitors of hepatitis C virus NS3-4A proteinase

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Efficient initiation of HCV RNA replication in cell culture

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Highly permissive cell lines for subgenomic and genomic hepatitis C virus RNA replication

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Structural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with Ribonucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

A mechanism for initiating RNA-dependent RNA polymerization

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Evolution, synthesis and SAR of tripeptide alpha-ketoacid inhibitors of the hepatitis C virus NS3/NS4A serine protease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Phenethyl amides as novel noncovalent inhibitors of hepatitis C virus NS3/4A protease: discovery, initial SAR, and molecular modeling

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Mechanism of action of foscarnet against viral polymerases

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Antiviral drugs: current state of the art.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

RNA-dependent RNA polymerase of hepatitis C virus.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

A zinc binding site in viral serine proteinases

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Solid phase synthesis of peptide aldehyde protease inhibitors. Probing the proteolytic sites of hepatitis C virus polyprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Synthetic inhibitors of elastase

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Characterization of soluble hepatitis C virus RNA-dependent RNA polymerase expressed in Escherichia coli

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Peptidic inhibitors of the hepatitis C virus serine protease within non-structural protein 3.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

In search of hepatitis C virus receptor(s).

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Genetic Analysis of Sequences in the 3' Nontranslated Region of Hepatitis C Virus That Are Important for RNA Replication

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Sequences in the 5' nontranslated region of hepatitis C virus required for RNA replication.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

A second hepatitis C virus-encoded proteinase

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Alpha-ketoamides, alpha-ketoesters and alpha-diketones as HCV NS3 protease inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Structure of the RNA-dependent RNA polymerase of poliovirus

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Inhibition of hepatitis-B-virus DNA polymerase by phosphonoformate: studies on its mode of action

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

A novel mechanism to ensure terminal initiation by hepatitis C virus NS5B polymerase

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

The hepatitis C virus nonstructural protein 4B is an integral endoplasmic reticulum membrane protein

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

The hepatitis C virus (HCV)-Trimera mouse: a model for evaluation of agents against HCV.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Potent peptide inhibitors of human hepatitis C virus NS3 protease are obtained by optimizing the cleavage products

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Optimization of the P'-region of peptide inhibitors of hepatitis C virus NS3/4A protease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Prime site binding inhibitors of a serine protease: NS3/4A of hepatitis C virus

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

The hepatitis C virus RNA-dependent RNA polymerase membrane insertion sequence is a transmembrane segment

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

The natural history of hepatitis C virus infection

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

C-terminal domain of the hepatitis C virus NS3 protein contains an RNA helicase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

In vivo determination of substrate specificity of hepatitis C virus NS3 protease: genetic assay for site-specific proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Role of charged residues in the catalytic mechanism of hepatitis C virus NS3 protease: electrostatic precollision guidance and transition-state stabilization

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Specificity of the hepatitis C virus NS3 serine protease: effects of substitutions at the 3/4A, 4A/4B, 4B/5A, and 5A/5B cleavage sites on polyprotein processing

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Identification of a highly conserved sequence element at the 3' terminus of hepatitis C virus genome RNA

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3' nontranslated region are essential for virus replication in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Enhancement of hepatitis C virus RNA replication by cell culture-adaptive mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Mechanistic role of an NS4A peptide cofactor with the truncated NS3 protease of hepatitis C virus: elucidation of the NS4A stimulatory effect via kinetic analysis and inhibitor mapping

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Mechanism of action of ribavirin in the combination treatment of chronic HCV infection

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Bacteriophage phi 6 RNA-dependent RNA polymerase: molecular details of initiating nucleic acid synthesis without primer

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Processing in the hepatitis C virus E2-NS2 region: identification of p7 and two distinct E2-specific products with different C termini

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Studies on the C-terminal of hexapeptide inhibitors of the hepatitis C virus serine protease.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Peptide-based inhibitors of the hepatitis C virus serine protease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Highly potent and selective peptide-based inhibitors of the hepatitis C virus serine protease: towards smaller inhibitors.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Biochemical and kinetic analyses of NS5B RNA-dependent RNA polymerase of the hepatitis C virus.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Binding of amino acid side-chains to S1 cavities of serine proteinases

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

De novo initiation of RNA synthesis by the RNA-dependent RNA polymerase (NS5B) of hepatitis C virus

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Hepatitis C virus RNA-dependent RNA polymerase (NS5B) as a mediator of the antiviral activity of ribavirin

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Solution structure and dynamics of the single-chain hepatitis C virus NS3 protease NS4A cofactor complex

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Hepatitis C virus replication in mice with chimeric human livers

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Alpha-ketoacids are potent slow binding inhibitors of the hepatitis C virus NS3 protease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Crystal structures of active and inactive conformations of a caliciviral RNA-dependent RNA polymerase

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Capped dipeptide alpha-ketoacid inhibitors of the HCV NS3 protease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

In vivo selection of protease cleavage sites by using chimeric Sindbis virus libraries

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Protein-primed RNA synthesis by purified poliovirus RNA polymerase

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Binding of hepatitis C virus to CD81

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Molecular model of the specificity pocket of the hepatitis C virus protease: implications for substrate recognition.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

1-Aminocyclopropaneboronic acid: synthesis and incorporation into an inhibitor of hepatitis C virus NS3 protease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

P1 Phenethyl peptide boronic acid inhibitors of HCV NS3 protease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Recent advances in the molecular biology of hepatitis C virus

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Small, noncovalent serine protease inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Biosynthesis and biochemical properties of the hepatitis C virus core protein

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

On the size of the active site in proteases. I. Papain

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Determinants for membrane association of the hepatitis C virus RNA-dependent RNA polymerase

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Selection of 3'-template bases and initiating nucleotides by hepatitis C virus NS5B RNA-dependent RNA polymerase

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Design and synthesis of ethyl pyrrolidine-5,5-trans-lactams as inhibitors of hepatitis C virus NS3/4A protease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Highly potent non-peptidic inhibitors of the HCV NS3/NS4A serine protease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Product inhibition of the hepatitis C virus NS3 protease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Hepatitis C virus protease inhibitors: current progress and future challenges

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Phosphonoformate Inhibits Reverse Transcriptase

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Structure and organization of the hepatitis C virus genome isolated from human carriers

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

How hepatitis C virus counteracts the interferon response: the jury is still out on NS5A.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

A novel sequence found at the 3' terminus of hepatitis C virus genome

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Inhibition of cap (m7GpppXm)-dependent endonuclease of influenza virus by 4-substituted 2,4-dioxobutanoic acid compounds

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Biochemical characterization of a hepatitis C virus RNA-dependent RNA polymerase mutant lacking the C-terminal hydrophobic sequence

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Internal ribosome entry site within hepatitis C virus RNA

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Substrate specificity of the hepatitis C virus serine protease NS3.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

The metal binding site of the hepatitis C virus NS3 protease. A spectroscopic investigation.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Evidence for a new hepatitis C virus antigen encoded in an overlapping reading frame

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Epidemiology of hepatitis C: geographic differences and temporal trends

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Synthesis of a novel hepatitis C virus protein by ribosomal frameshift

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: A 2.2 Å resolution structure in a hexagonal crystal form

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease-helicase

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Structure-activity relationship studies of a bisbenzimidazole-based, Zn(2+)-dependent inhibitor of HCV NS3 serine protease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

Azapeptides as inhibitors of the hepatitis C virus NS3 serine protease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

De novo initiation of RNA synthesis by hepatitis C virus nonstructural protein 5B polymerase

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2803%2900028-7

7 January 2021

10.1016/S0166-3542(03)00028-7

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12719002%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

1 reference