(Q35119517)

6 August 2017

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title

Targeting DNA methylation in cancer (English)

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6 August 2017

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Moshe Szyf

1

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6 August 2017

1 July 2003

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6 August 2017

Ageing Research Reviews

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6 August 2017

2

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6 August 2017

299-328

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6 August 2017

3

1 reference

The DNMT1 target recognition domain resides in the N terminus

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Recombinant human DNA (cytosine-5) methyltransferase. II. Steady-state kinetics reveal allosteric activation by methylated dna.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

DNA hypermethylation in tumorigenesis: epigenetics joins genetics

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

An essential role for DNA methyltransferase DNMT3B in cancer cell survival

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

A mammalian protein with specific demethylase activity for mCpG DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Modified oligonucleotides as bona fide antagonists of proteins interacting with DNA. Hairpin antagonists of the human DNA methyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

MeCP2 and MBD2 expression during normal and pathological growth of the human mammary gland

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Dnmt1 overexpression causes genomic hypermethylation, loss of imprinting, and embryonic lethality

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

CpG-rich islands and the function of DNA methylation

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Demethylase activity is directed by histone acetylation

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

The oncoprotein Set/TAF-1beta, an inhibitor of histone acetyltransferase, inhibits active demethylation of DNA, integrating DNA methylation and transcriptional silencing

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

DNA hypomethylation leads to elevated mutation rates

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

AdoMet-dependent methylation, DNA methyltransferases and base flipping

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21WAF1

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

CpG methylation inhibits proenkephalin gene expression and binding of the transcription factor AP-2

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

A conserved 3'-untranslated element mediates growth regulation of DNA methyltransferase 1 and inhibits its transforming activity

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Promoter-specific activation and demethylation by MBD2/demethylase

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

DNA hypomethylation, cancer, the immunodeficiency, centromeric region instability, facial anomalies syndrome and chromosomal rearrangements

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

DNA methylation in cancer: too much, but also too little

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Hypomethylation and hypermethylation of DNA in Wilms tumors.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Hypomethylation of ras oncogenes in primary human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Down-regulation of human DNA-(cytosine-5) methyltransferase induces cell cycle regulators p16(ink4A) and p21(WAF/Cip1) by distinct mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

DNA methyltransferase Dnmt1 associates with histone deacetylase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Regulation of DNA methylation in human breast cancer. Effect on the urokinase-type plasminogen activator gene production and tumor invasion

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Induction of invasive and metastatic potential in mouse T-lymphoma cells (BW5147) by treatment with 5-azacytidine

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

DNA demethylase expression correlates with lung resistance protein expression in common epithelial ovarian cancers

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Identification and characterization of a family of mammalian methyl-CpG binding proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Increased cytosine DNA-methyltransferase activity during colon cancer progression

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

DNA demethylation and pericentromeric rearrangements of chromosome 1.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Altering gene expression with 5-azacytidine

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Mechanisms of DNA demethylation in chicken embryos. Purification and properties of a 5-methylcytosine-DNA glycosylase

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Reduced mRNA expression of the DNA demethylase, MBD2, in human colorectal and stomach cancers.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Effect of regional DNA methylation on gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

A role for nuclear NF-kappaB in B-cell-specific demethylation of the Igkappa locus

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Inhibition of DNA methyltransferase inhibits DNA replication

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Heterogeneity in the modification and involvement of chromatin components of the CpG island of the silenced human CDH1 gene in cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Suppression of intestinal neoplasia by DNA hypomethylation.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Limited up-regulation of DNA methyltransferase in human colon cancer reflecting increased cell proliferation.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Modulation of DNA binding protein affinity directly affects target site demethylation

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

The dynamics of myogenin site-specific demethylation is strongly correlated with its expression and with muscle differentiation.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Regulation of DNA methylation by the Ras signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

DNA methyltransferase inhibition induces the transcription of the tumor suppressor p21(WAF1/CIP1/sdi1).

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Active demethylation of the paternal genome in the mouse zygote

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Dynamics of demethylation and activation of the alpha-actin gene in myoblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Reversal by 5-azacytidine of the S-adenosyl-l-methionine-induced inhibition of the development of putative preneoplastic foci in rat liver carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Chemoprevention of hepatocarcinogenesis: S-adenosyl-L-methionine

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

DNA methyltransferase and demethylase in human prostate cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

The effects of diet, genetics and chemicals on toxicity and aberrant DNA methylation: an introduction.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Methyl supply, methyl metabolizing enzymes and colorectal neoplasia

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

DNA methylation is a reversible biological signal

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Distribution of 5-methylcytosine in chromatin

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

DNA Methylation and Gene Function

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

DNA methylation patterns. Formation and function

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Replacement of 5-methylcytosine by cytosine: a possible mechanism for transient DNA demethylation during differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

The expression of DNA methyltransferases and methyl-CpG-binding proteins is not associated with the methylation status of p14(ARF), p16(INK4a) and RASSF1A in human lung cancer cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

DNA, FISH and complementation studies in ICF syndrome: DNA hypomethylation of repetitive and single copy loci and evidence for a trans acting factor

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Trichostatin A causes selective loss of DNA methylation in Neurospora

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Antisense MBD2 gene therapy inhibits tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

The language of covalent histone modifications

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

DNA methylation patterns: an additional level of information?

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

The DNA methylation machinery as a target for anticancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Towards a pharmacology of DNA methylation

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Cellular and viral DNA hypomethylation associated with induction of Epstein-Barr virus lytic cycle

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Nucleotide-sequence-specific de novo methylation in a somatic murine cell line

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Modification of the metastatic potential of tumor cells by drugs

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

A histone H3 methyltransferase controls DNA methylation in Neurospora crassa

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

5-Methylcytosine DNA glycosylase activity is also present in the human MBD4 (G/T mismatch glycosylase) and in a related avian sequence

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

5-methylcytosine-DNA glycosylase activity is present in a cloned G/T mismatch DNA glycosylase associated with the chicken embryo DNA demethylation complex

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

Overexpression of 5-methylcytosine DNA glycosylase in human embryonic kidney cells EcR293 demethylates the promoter of a hormone-regulated reporter gene

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900012-6

7 January 2021

10.1016/S1568-1637(03)00012-6

Identifiers

DOI

1 reference

6 August 2017

1 reference

PubMed ID

12726777