(Q35143252)

6 August 2017

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title

Technical and regulatory hurdles for DNA vaccines (English)

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6 August 2017

John Donnelly

1

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6 August 2017

Karin Berry

series ordinal

2

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6 August 2017

Jeffrey B Ulmer

series ordinal

3

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6 August 2017

language of work or name

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1 May 2003

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International Journal for Parasitology

6 August 2017

published in

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6 August 2017

volume

33

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6 August 2017

issue

5-6

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6 August 2017

page(s)

457-467

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Stability of peptide-condensed plasmid DNA formulations

6 August 2017

cites work

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7 January 2021

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Electric pulses increase the immunogenicity of an influenza DNA vaccine injected intramuscularly in the mouse

7 January 2021

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The immunotargeting approach to adjuvant-independent subunit vaccine design

7 January 2021

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The ability of an oligomeric human immunodeficiency virus type 1 (HIV-1) envelope antigen to elicit neutralizing antibodies against primary HIV-1 isolates is improved following partial deletion of the second hypervariable region

7 January 2021

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Augmentation of immune responses to HIV-1 and simian immunodeficiency virus DNA vaccines by IL-2/Ig plasmid administration in rhesus monkeys

7 January 2021

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Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination

7 January 2021

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Elicitation of high-frequency cytotoxic T-lymphocyte responses against both dominant and subdominant simian-human immunodeficiency virus epitopes by DNA vaccination of rhesus monkeys

7 January 2021

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Biological features of genetic immunization

7 January 2021

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Modulation of cellular and humoral immune responses to a multiepitopic HIV-1 DNA vaccine by interleukin-18 DNA immunization/viral protein boost

7 January 2021

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Enhancement of cellular immune response in HIV-1 seropositive individuals: A DNA-based trial

7 January 2021

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Vaccination of seronegative volunteers with a human immunodeficiency virus type 1 env/rev DNA vaccine induces antigen-specific proliferation and lymphocyte production of beta-chemokines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

CpG DNA can induce strong Th1 humoral and cell-mediated immune responses against hepatitis B surface antigen in young mice

7 January 2021

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The preparation, characterization, and evaluation of cationic microparticles for DNA vaccine delivery.

7 January 2021

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Plasmids encoding granulocyte-macrophage colony-stimulating factor and CD154 enhance the immune response to genetic vaccines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

DNA vaccination with the human immunodeficiency virus type 1 SF162DeltaV2 envelope elicits immune responses that offer partial protection from simian/human immunodeficiency virus infection to CD8(+) T-cell-depleted rhesus macaques

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

DNA-based immunization by in vivo transfection of dendritic cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Chitosan-based nanoparticles for topical genetic immunization

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Immune induction and modulation by topical ocular administration of plasmid DNA encoding antigens and cytokines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Oral delivery of DNA vaccines using attenuated Salmonella typhimurium as carrier.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Direct gene transfer in skeletal muscle: plasmid DNA-based immunization against the hepatitis B virus surface antigen

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Plasmid DNA adsorbed onto cationic microparticles mediates target gene expression and antigen presentation by dendritic cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Gram-positive and Gram-negative bacteria as carrier systems for DNA vaccines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Induction of cytotoxic T lymphocytes by intramuscular immunization with plasmid DNA is facilitated by bone marrow-derived cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Preclinical efficacy of a prototype DNA vaccine: Enhanced protection against antigenic drift in influenza virus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Protection against papillomavirus with a polynucleotide vaccine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

The comparative efficacy of CTLA-4 and L-selectin targeted DNA vaccines in mice and sheep.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Immunopotentiation of DNA vaccine against herpes simplex virus via co-delivery of plasmid DNA expressing CCR7 ligands

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Immunization via hair follicles by topical application of naked DNA to normal skin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Murine dendritic cells pulsed with whole tumor lysates mediate potent antitumor immune responses in vitro and in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Priming of cytotoxic T lymphocytes by DNA vaccines: requirement for professional antigen presenting cells and evidence for antigen transfer from myocytes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Induction of MHC class I-restricted CTL response by DNA immunization with ubiquitin-influenza virus nucleoprotein fusion antigens

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Combination of gene delivery and DNA vaccination to protect from and reverse Th1 autoimmune disease via deviation to the Th2 pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Immunogenicity of two doses of yeast recombinant hepatitis B vaccine in healthy older adults.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Recombinant attenuated bacteria for the delivery of subunit vaccines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Liposome-mediated DNA vaccination

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Codon usage limitation in the expression of HIV-1 envelope glycoprotein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Feline leukemia virus DNA vaccine efficacy is enhanced by coadministration with interleukin-12 (IL-12) and IL-18 expression vectors.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Vaxfectin enhances the humoral immune response to plasmid DNA-encoded antigens

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

A Toll-like receptor recognizes bacterial DNA

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Vaccination with yeast-expressed cottontail rabbit papillomavirus (CRPV) virus-like particles protects rabbits from CRPV-induced papilloma formation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Poly(DL-lactide-co-glycolide)-encapsulated plasmid DNA elicits systemic and mucosal antibody responses to encoded protein after oral administration.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Modulation of antigen-specific cellular immune responses to DNA vaccination in rhesus macaques through the use of IL-2, IFN-gamma, or IL-4 gene adjuvants

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

DNA vaccines with single-chain Fv fused to fragment C of tetanus toxin induce protective immunity against lymphoma and myeloma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Mucosal immunization with DNA-liposome complexes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

CpG motifs as immune adjuvants

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

CpG motifs in bacterial DNA trigger direct B-cell activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Safety, tolerability and humoral immune responses after intramuscular administration of a malaria DNA vaccine to healthy adult volunteers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Induction of antibodies against Salmonella typhi OmpC porin by naked DNA immunization.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Tissue distribution and persistence in mice of plasmid DNA encapsulated in a PLGA-based microsphere delivery vehicle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Safety and immune responses to a DNA-based human immunodeficiency virus (HIV) type I env/rev vaccine in HIV-infected recipients: follow-up data

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

First human trial of a DNA-based vaccine for treatment of human immunodeficiency virus type 1 infection: safety and host response

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Chitosan and depolymerized chitosan oligomers as condensing carriers for in vivo plasmid delivery

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Biodistribution and gene expression of lipid/plasmid complexes after systemic administration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Plasmid DNA vaccines: tissue distribution and effects of DNA sequence, adjuvants and delivery method on integration into host DNA

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Direct gene transfer to the respiratory tract of mice with pure plasmid and lipid-formulated DNA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Intracellular bacteria as targets and carriers for vaccination

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Protein expression in vivo by injection of polynucleotides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Polyvinyl derivatives as novel interactive polymers for controlled gene delivery to muscle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Direct gene transfer for treatment of human cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Immune response in human melanoma after transfer of an allogeneic class I major histocompatibility complex gene with DNA-liposome complexes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Induction of potent immune responses by cationic microparticles with adsorbed human immunodeficiency virus DNA vaccines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Genetic immunization with lung-targeting macroaggregated polyethyleneimine-albumin conjugates elicits combined systemic and mucosal immune responses

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Tissue distribution of the cytofectin component of a plasmid-DNA/cationic lipid complex following intravenous administration in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Liposome-mediated DNA vaccination: the effect of vesicle composition

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Gene gun-based nucleic acid immunization: elicitation of humoral and cytotoxic T lymphocyte responses following epidermal delivery of nanogram quantities of DNA

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Predominant role for directly transfected dendritic cells in antigen presentation to CD8+ T cells after gene gun immunization.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Efficient and regulated erythropoietin production by naked DNA injection and muscle electroporation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Protection against a lethal influenza virus challenge by immunization with a haemagglutinin-expressing plasmid DNA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Induction of antigen-specific CD8+ T cells, T helper cells, and protective levels of antibody in humans by particle-mediated administration of a hepatitis B virus DNA vaccine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Are DNA-based vaccines useful for protection against secreted bacterial toxins? Tetanus toxin test case

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Immunostimulatory DNA sequences necessary for effective intradermal gene immunization

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Enhancement of DNA vaccine potency by electroporation in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Vaccination with a Shigella DNA vaccine vector induces antigen-specific CD8(+) T cells and antiviral protective immunity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Recent advances with recombinant bacterial vaccine vectors.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Mucosal and systemic HIV-1 Env-specific CD8(+) T-cells develop after intragastric vaccination with a Salmonella Env DNA vaccine vector.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Systemic administration of interleukin 2 enhances the therapeutic efficacy of dendritic cell-based tumor vaccines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

DNA encoding individual mycobacterial antigens protects mice against tuberculosis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Cationic microparticles: A potent delivery system for DNA vaccines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Attenuated Shigella as a DNA delivery vehicle for DNA-mediated immunization

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

The regulation of DNA vaccines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Novel bacterial systems for the delivery of recombinant protein or DNA

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Phase 1 safety and immune response studies of a DNA vaccine encoding hepatitis B surface antigen delivered by a gene delivery device

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Genetic immunization is a simple method for eliciting an immune response

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

DNA vaccination with HIV-1 expressing constructs elicits immune responses in humans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Heterologous protection against influenza by injection of DNA encoding a viral protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Generation of MHC class I-restricted cytotoxic T lymphocytes by expression of a viral protein in muscle cells: antigen presentation by non-muscle cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Enhancement of DNA vaccine potency using conventional aluminum adjuvants

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Gene inoculation generates immune responses against human immunodeficiency virus type 1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Induction of CD4(+) T cell-dependent CD8(+) type 1 responses in humans by a malaria DNA vaccine.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Reduction of antigen expression from DNA vaccines by coadministered oligodeoxynucleotides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Improvement of the immune response against plasmid DNA encoding OspC of Borrelia by an ER-targeting leader sequence

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Evaluation of plasmid DNA for in vivo gene therapy: factors affecting the number of transfected fibers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Increased DNA vaccine delivery and immunogenicity by electroporation in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Direct gene transfer into mouse muscle in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Increased expression and immunogenicity of sequence-modified human immunodeficiency virus type 1 gag gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

Improvement of hepatitis B virus DNA vaccines by plasmids coexpressing hepatitis B surface antigen and interleukin-2.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

7 January 2021

Bovine herpesvirus 1: immune responses in mice and cattle injected with plasmid DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

7 January 2021

Sindbis virus DNA-based expression vectors: utility for in vitro and in vivo gene transfer.

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

7 January 2021

DNA immunization against herpes simplex virus: enhanced efficacy using a Sindbis virus-based vector

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

7 January 2021

Enhancement of immune response to naked DNA vaccine by immunization with transfected dendritic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

7 January 2021

DNA immunization: ubiquitination of a viral protein enhances cytotoxic T-lymphocyte induction and antiviral protection but abrogates antibody induction

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900056-0

7 January 2021

10.1016/S0020-7519(03)00056-0

Identifiers

DOI

1 reference

6 August 2017

1 reference