(Q35163593)

6 August 2017

title

Isothermal chemical denaturation to determine binding affinity of small molecules to G-protein coupled receptors (English)

1 reference

G protein-coupled receptor

6 August 2017

main subject

0 references

1 reference

Patrick Ross

1

1 reference

6 August 2017

Wilhelm Weihofen

2

1 reference

6 August 2017

Fai Siu

3

1 reference

6 August 2017

Amy Xie

4

1 reference

6 August 2017

Hetal Katakia

5

1 reference

6 August 2017

S Kirk Wright

6

1 reference

6 August 2017

Ian Hunt

7

1 reference

6 August 2017

Richard K Brown

8

1 reference

6 August 2017

Ernesto Freire

9

1 reference

6 August 2017

language of work or name

English

0 references

publication date

4 December 2014

1 reference

6 August 2017

published in

Analytical Biochemistry

1 reference

6 August 2017

volume

473

1 reference

6 August 2017

page(s)

41-45

1 reference

Ligand binding analysis and screening by chemical denaturation shift

6 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355058

Pharmacology and structure of isolated conformations of the adenosine A₂A receptor define ligand efficacy

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355058

Fusion partner toolchest for the stabilization and crystallization of G protein-coupled receptors

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355058

Structure-based drug screening for G-protein-coupled receptors

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355058

Tools for GPCR drug discovery

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355058

Discovery of 1,2,4-Triazine Derivatives as Adenosine A 2A Antagonists using Structure Based Drug Design

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355058

Diversity and modularity of G protein-coupled receptor structures

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355058

Biophysical mapping of the adenosine A2A receptor

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355058

Biophysical characterization of G-protein coupled receptor-peptide ligand binding

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355058

The structural basis of agonist-induced activation in constitutively active rhodopsin

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355058

Biacore analysis with stabilized G-protein-coupled receptors

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355058

Label-free cell-based assays for GPCR screening.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355058

Thermodynamic stability of carbonic anhydrase: measurements of binding affinity and stoichiometry using ThermoFluor.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355058

Design, radiosynthesis, and biodistribution of a new potent and selective ligand for in vivo imaging of the adenosine A(2A) receptor system using positron emission tomography

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355058

Unfolding free energy changes determined by the linear extrapolation method. 1. Unfolding of phenylmethanesulfonyl alpha-chymotrypsin using different denaturants

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355058

The properties of thermostabilised G protein-coupled receptors (StaRs) and their use in drug discovery.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4355058

Analyzing ligand and small molecule binding activity of solubilized GPCRs using biosensor technology

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25481736

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A high-throughput fluorescence chemical denaturation assay as a general screen for protein-ligand binding

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25481736

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Unfolding free energy changes determined by the linear extrapolation method. 2. Incorporation of delta G degrees N-U values in a thermodynamic cycle.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25481736

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.AB.2014.11.019

1 reference

6 August 2017

1 reference

6 August 2017

1 reference