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The camptothecins.
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12842380
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12842380%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
review article
1 reference
stated in
Europe PubMed Central
title
The camptothecins
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12842380
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12842380%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
author
Leonard B. Saltz
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12842380
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12842380%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
author name string
Joseph F Pizzolato
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12842380
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12842380%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
language of work or name
English
0 references
publication date
1 June 2003
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12842380
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12842380%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
published in
The Lancet
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12842380
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12842380%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
volume
361
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12842380
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12842380%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
issue
9376
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12842380
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12842380%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
page(s)
2235-2242
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12842380
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12842380%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
cites work
Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata1,2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA topoisomerase I--targeted chemotherapy of human colon cancer in xenografts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Synthesis of water-soluble (aminoalkyl)camptothecin analogs: inhibition of topoisomerase I and antitumor activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evaluation of 9-dimethylaminomethyl-10-hydroxycamptothecin against xenografts derived from adult and childhood solid tumors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Successful local regional therapy with topotecan of intraperitoneally growing human ovarian carcinoma xenografts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phase I and pharmacokinetics study of topotecan, a new topoisomerase I inhibitor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phase I clinical and pharmacology study of topotecan given daily for 5 consecutive days to patients with advanced solid tumors, with attempt at dose intensification using recombinant granulocyte colony-stimulating factor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phase I trial of low-dose continuous topotecan infusion in patients with cancer: an active and well-tolerated regimen
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phase II trial of topotecan administered as a 21-day continuous infusion in previously untreated patients with stage IIIB and IV non-small-cell lung cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Continuous infusional topotecan in advanced breast and non-small-cell lung cancer: no evidence of increased efficacy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phase II evaluation of topotecan in patients with advanced colorectal cancer. A Southwest Oncology Group trial (SWOG 9241).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Topotecan in colorectal cancer: a phase II study of the EORTC early clinical trials group
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A phase II study of topotecan administered five times daily in patients with advanced gastric cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Topotecan versus paclitaxel for the treatment of recurrent epithelial ovarian cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Topotecan in combination with carboplatin: phase I trial evaluation of two treatment schedules.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Developmental chemotherapy in advanced ovarian cancer: incorporation of newer cytotoxic agents in a phase III randomized trial of the Gynecologic Oncology Group (GOG-0182).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Five days of oral topotecan (Hycamtin), a phase I and pharmacological study in adult patients with solid tumours
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oral topotecan as single-agent second-line chemotherapy in patients with advanced ovarian cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A randomised trial of oral versus intravenous topotecan in patients with relapsed epithelial ovarian cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Topotecan versus observation after cisplatin plus etoposide in extensive-stage small-cell lung cancer: E7593--a phase III trial of the Eastern Cooperative Oncology Group
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Topotecan, a new active drug in the second-line treatment of small-cell lung cancer: a phase II study in patients with refractory and sensitive disease. The European Organization for Research and Treatment of Cancer Early Clinical Studies Group and
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phase II study of topotecan in patients with extensive-stage small-cell carcinoma of the lung: an Eastern Cooperative Oncology Group Trial
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phase ii comparator study of oral versus intravenous topotecan in patients with chemosensitive small-cell lung cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phase I Study and Pharmacokinetics of CPT-11 With 5-Day Continuous Infusion
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phase I Study of Weekly Intravenous Infusions of CPT-11, a New Derivative of Camptothecin, in the Treatment of Advanced Non-Small-Cell Lung Cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Modulation of glucuronidation of SN-38, the active metabolite of irinotecan, by valproic acid and phenobarbital
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Severe CPT-11 toxicity in patients with Gilbert's syndrome: two case reports
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phase I and pharmacokinetic trial of weekly CPT-11
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Antitumor activity of a camptothecin derivative, CPT-11, against human tumor xenografts in nude mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Population pharmacokinetics and pharmacodynamics of irinotecan (CPT-11) and active metabolite SN-38 during phase I trials
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Irinotecan is an active agent in untreated patients with metastatic colorectal cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Randomised trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Randomised trial of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Irinotecan (CPT-11) high-dose escalation using intensive high-dose loperamide to control diarrhea
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pathophysiology and therapy of irinotecan-induced delayed-onset diarrhea in patients with advanced colorectal cancer: a prospective assessment
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of acetorphan, an enkephalinase inhibitor, on experimental and acute diarrhoea
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phase II study of CPT-11, a new camptothecin derivative, in metastatic colorectal cancer. CPT-11 Gastrointestinal Cancer Study Group.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phase I clinical and pharmacokinetic study of irinotecan, fluorouracil, and leucovorin in patients with advanced solid tumors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of CPT-11 in combination with other anti-cancer agents in culture
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phase I clinical and pharmacologic study of weekly cisplatin combined with weekly irinotecan in patients with advanced solid tumors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phase II trial of weekly irinotecan plus cisplatin in advanced esophageal cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phase II study of a combination of irinotecan and cisplatin against metastatic gastric cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phase II trial of CPT-11 in patients with advanced pancreatic cancer, an EORTC early clinical trials group study
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Irinotecan plus gemcitabine induces both radiographic and CA 19-9 tumor marker responses in patients with previously untreated advanced pancreatic cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Preoperative induction chemotherapy with cisplatin and irinotecan for pathological N(2) non-small cell lung cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Irinotecan plus cisplatin compared with etoposide plus cisplatin for extensive small-cell lung cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phase II trial of 9-aminocamptothecin administered as a 72-hour continuous infusion in metastatic colorectal carcinoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
9-Aminocamptothecin by 72-hour continuous intravenous infusion is inactive in the treatment of patients with 5-fluorouracil-refractory colorectal carcinoma.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A phase II trial of 9-aminocaptothecin (9-AC) as a 120-h infusion in patients with non-small cell lung cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phase I and pharmacologic study of 9-aminocamptothecin colloidal dispersion formulation given as a 24-hour continuous infusion weekly times four every 5 weeks
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A phase II clinical and pharmacological study of oral 9-nitrocamptothecin in patients with refractory epithelial ovarian, tubal or peritoneal cancer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Multicentre phase II and pharmacokinetic study of RFS2000 (9-nitro-camptothecin) administered orally 5 days a week in patients with glioblastoma multiforme
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phase II trial of 9-nitrocamptothecin (RFS 2000) for patients with metastatic cutaneous or uveal melanoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DX-8951f, a hexacyclic camptothecin analog, on a daily-times-five schedule: a phase I and pharmacokinetic study in patients with advanced solid malignancies
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phase I and pharmacologic study of oral (PEG-1000) 9-aminocamptothecin in adult patients with solid tumors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0140-6736%2803%2913780-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0140-6736(03)13780-4
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12842380
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12842380%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
PubMed publication ID
12842380
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12842380
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12842380%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 November 2019
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