(Q35181928)

7 August 2017

title

Chemical Probe Identification Platform for Orphan GPCRs Using Focused Compound Screening: GPR39 as a Case Example (English)

1 reference

G protein-coupled receptor

7 August 2017

main subject

0 references

author

Shawn Cabral

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900608%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

John Hadcock

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900608%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

author name string

Markus Boehm

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900608%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

David Hepworth

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900608%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Paula M Loria

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900608%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Lisa D Norquay

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900608%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Kevin J Filipski

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900608%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Janice E Chin

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900608%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Kimberly O Cameron

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900608%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Martin Brenner

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900608%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Peter Bonnette

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900608%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Edward Conn

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900608%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

David C Ebner

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900608%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Denise Gautreau

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900608%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Esther C Y Lee

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900608%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Alan M Mathiowetz

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900608%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Michelle Morin

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900608%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Lucy Rogers

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900608%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Aaron Smith

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900608%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Maria VanVolkenburg

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900608%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Philip A Carpino

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900608%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

publication date

16 September 2013

1 reference

ACS Medicinal Chemistry Letters

7 August 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900608%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

volume

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900608%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900608%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

page(s)

1079-1084

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900608%20AND%20SRC:MED&resulttype=core&format=json

Metal impurities cause false positives in high-throughput screening campaigns

7 June 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027148

G protein-coupled receptor deorphanizations

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027148

β-Cell Specific Overexpression of GPR39 Protects against Streptozotocin-Induced Hyperglycemia

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027148

ChEMBL: a large-scale bioactivity database for drug discovery

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027148

Development of a new permeability assay using low-efflux MDCKII cells.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027148

GPR39: a Zn2+-activated G protein-coupled receptor that regulates pancreatic, gastrointestinal and neuronal functions

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027148

Fine-tuning of GPCR activity by receptor-interacting proteins

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027148

Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027148

Disruption of G protein-coupled receptor 39 impairs insulin secretion in vivo

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027148

G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027148

Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027148

Isolation of Zn2+ as an endogenous agonist of GPR39 from fetal bovine serum

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027148

Lack of obestatin effects on food intake: should obestatin be renamed ghrelin-associated peptide (GAP)?

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027148

GPR39 signaling is stimulated by zinc ions but not by obestatin

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027148

Recent developments in focused library design: targeting gene-families

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027148

Orphan G protein-coupled receptors: targets for new therapeutic interventions

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027148

The design of screening libraries targeted at G-protein coupled receptors

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027148

Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027148

The properties of known drugs. 1. Molecular frameworks

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027148

Discovery of the first nonpeptidic, small-molecule, highly selective somatostatin receptor subtype 5 antagonists: a chemogenomics approach

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027148

Using extended-connectivity fingerprints with Laplacian-modified Bayesian analysis in high-throughput screening follow-up

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027148

Comparison of Shape-Matching and Docking as Virtual Screening Tools

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4027148

GPR39, a receptor of the ghrelin receptor family, plays a role in the regulation of glucose homeostasis in a mouse model of early onset diet-induced obesity

8 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24900608

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/ML400275Z

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900608%20AND%20SRC:MED&resulttype=core&format=json

release_2ojsctcaxrdldoaexa6or4yc64

7 June 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/2ojsctcaxrdldoaexa6or4yc64

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24900608%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

1 reference